Rheumatology Flashcards
What 2 conditions are associated with anti-U1-RNP antibody?
Mixed connective tissue disease
Systemic lupus erythematous
Which 2 endocrine disorders are associated with calcium pyrophosphate disease?
Acromegaly
Hyperparathyroidism
What is primary treatment of axial seronegative spondyloarthropathies?
NSAIDS, non biologic DMARDs
What 2 conditions are associated with positive p-ANCA?
Microscopic polyangiitis (MPA) Churg-Strauss syndrome
What is the rheumatologic condition associated with chondrocalcinosis of the knees, shoulders, wrists, and pubic symphysis?
Calcium pyrophosphate deposition disease
What dose of chronic steroids is associated with increased risk of osteoporosis?
> 7.5 mg PO daily x 3 months
Which are 4 DMARDs that have high risk of teratogenicity and should always be avoided in pregnancy if at all possible?
Methotrexate
Leflunomide
Cyclophosphamide
Mycophenilate mofetil
What drug can be given to speed removal of leflunomide from the body?
Cholestyramine TID x 8 days
What enzyme level should be checked prior to initiation of azathioprine?
TPMT level
What rare, severe neurological disorder can be seen with rituximab infusions?
Progressive multi focal leukoencephalopathy/JC virus
What condition is belimumab (anti-BAFF monoclonal antibody) used to treat?
SLE
Which urate lowering agent helps with under excretors of urate in the kidney?
Probenecid- avoid if history or kidney stones or tophaceous gout
Which inflammatory myositis more commonly involves distal muscle groups?
Inclusion body myositis
Is limited or diffuse cutaneous systemic sclerosis more likely to develop PAH?
Limited (including CREST syndrome)
What complication can occur if patients with scleroderma are given oral corticosteroids?
Can potentially precipitate scleroderma renal crisis
What is common triad of scleroderma renal crisis?
Sudden onset hypertension, azotemia, and microangiopathic hemolytic anemia - treat with ACEI
What is main treatment of ILD in scleroderma?
Cyclophosphamide
What is main treatment of skin/joint symptoms in scleroderma?
Methotrexate
Which antibody titer in scleroderma is most associated with development of ILD?
Anti-Scl-70
What scleroderma spectrum disorder spares the digits and face?
Eosinophilic fasciitis
What malignancy are patients with Sjogren’s at increased risk (44x more likely) to get?
Lymphoma or MALToma
What is the most frequent cardiac manifestation of mixed connective tissue disease?
Pericardial effusion
What is treatment of PAH in setting of MCTD?
Cyclophosphamide
Which blood pressure medications can precipitate gout attacks?
Thiazides and loop diuretics
What condition has positively birefringint rhomboid crystals?
Calcium pyrophosphate deposition disease (pseudogout)
Which type of myositis commonly has dysphagia associated with it?
Inclusion body myositis
What concurrent disease is more likely to cause Kawasaki disease in adults?
HIV
Which HLA is associated with Bechet disease?
HLA B51
What disorder presents with recurrent swelling and pain of the external ear?
Relapsing polychondritis
How often are fevers in adult onset Stills disease?
Quotidian aka daily
What color is rash in adult onset stills disease?
Salmon colored
What lab level can help diagnose adult onset stills disease?
Extremely elevated ferritin >1000
What complication are patients with familial Mediterranean fever at risk to develop?
Amyloidosis
How often are fevers in FMF?
Every 12-72 hrs
What is the 1st and 2nd treatments for axial involvement in seronegative spondyloarthropathies?
1 -NSAIDS
2- TNFa inhibitors
Which TNFa inhibitor should not be used for IBD associated arthritis?
Etanercept
What crystal disorder presents usually in setting of trauma with joint effusion but the crystals cannot be seen under polarized light?
Basic calcium phosphate deposition disease (requires alizarin stain to see crystals)
What underlying malignancy may be associated with HSP in adults?
MDS
