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Internal Medicine > Rheumatology > Flashcards

Rheumatology Flashcards

0
Q

What 2 conditions are associated with anti-U1-RNP antibody?

A

Mixed connective tissue disease

Systemic lupus erythematous

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1
Q

Which 2 endocrine disorders are associated with calcium pyrophosphate disease?

A

Acromegaly

Hyperparathyroidism

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2
Q

What is primary treatment of axial seronegative spondyloarthropathies?

A

NSAIDS, non biologic DMARDs

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3
Q

What 2 conditions are associated with positive p-ANCA?

A 
Microscopic polyangiitis (MPA)
Churg-Strauss syndrome
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4
Q

What is the rheumatologic condition associated with chondrocalcinosis of the knees, shoulders, wrists, and pubic symphysis?

A

Calcium pyrophosphate deposition disease

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5
Q

What dose of chronic steroids is associated with increased risk of osteoporosis?

A

> 7.5 mg PO daily x 3 months

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6
Q

Which are 4 DMARDs that have high risk of teratogenicity and should always be avoided in pregnancy if at all possible?

A

Methotrexate
Leflunomide
Cyclophosphamide
Mycophenilate mofetil

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7
Q

What drug can be given to speed removal of leflunomide from the body?

A

Cholestyramine TID x 8 days

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8
Q

What enzyme level should be checked prior to initiation of azathioprine?

A

TPMT level

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9
Q

What rare, severe neurological disorder can be seen with rituximab infusions?

A

Progressive multi focal leukoencephalopathy/JC virus

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10
Q

What condition is belimumab (anti-BAFF monoclonal antibody) used to treat?

A

SLE

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11
Q

Which urate lowering agent helps with under excretors of urate in the kidney?

A

Probenecid- avoid if history or kidney stones or tophaceous gout

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12
Q

Which inflammatory myositis more commonly involves distal muscle groups?

A

Inclusion body myositis

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13
Q

Is limited or diffuse cutaneous systemic sclerosis more likely to develop PAH?

A

Limited (including CREST syndrome)

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14
Q

What complication can occur if patients with scleroderma are given oral corticosteroids?

A

Can potentially precipitate scleroderma renal crisis

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15
Q

What is common triad of scleroderma renal crisis?

A

Sudden onset hypertension, azotemia, and microangiopathic hemolytic anemia - treat with ACEI

16
Q

What is main treatment of ILD in scleroderma?

A

Cyclophosphamide

17
Q

What is main treatment of skin/joint symptoms in scleroderma?

A

Methotrexate

18
Q

Which antibody titer in scleroderma is most associated with development of ILD?

A

Anti-Scl-70

19
Q

What scleroderma spectrum disorder spares the digits and face?

A

Eosinophilic fasciitis

20
Q

What malignancy are patients with Sjogren’s at increased risk (44x more likely) to get?

A

Lymphoma or MALToma

21
Q

What is the most frequent cardiac manifestation of mixed connective tissue disease?

A

Pericardial effusion

22
Q

What is treatment of PAH in setting of MCTD?

A

Cyclophosphamide

23
Q

Which blood pressure medications can precipitate gout attacks?

A

Thiazides and loop diuretics

24
Q

What condition has positively birefringint rhomboid crystals?

A

Calcium pyrophosphate deposition disease (pseudogout)

25
Q

Which type of myositis commonly has dysphagia associated with it?

A

Inclusion body myositis

26
Q

What concurrent disease is more likely to cause Kawasaki disease in adults?

A

HIV

27
Q

Which HLA is associated with Bechet disease?

A

HLA B51

28
Q

What disorder presents with recurrent swelling and pain of the external ear?

A

Relapsing polychondritis

29
Q

How often are fevers in adult onset Stills disease?

A

Quotidian aka daily

30
Q

What color is rash in adult onset stills disease?

A

Salmon colored

31
Q

What lab level can help diagnose adult onset stills disease?

A

Extremely elevated ferritin >1000

32
Q

What complication are patients with familial Mediterranean fever at risk to develop?

A

Amyloidosis

33
Q

How often are fevers in FMF?

A

Every 12-72 hrs

34
Q

What is the 1st and 2nd treatments for axial involvement in seronegative spondyloarthropathies?

A

1 -NSAIDS

2- TNFa inhibitors

35
Q

Which TNFa inhibitor should not be used for IBD associated arthritis?

A

Etanercept

36
Q

What crystal disorder presents usually in setting of trauma with joint effusion but the crystals cannot be seen under polarized light?

A

Basic calcium phosphate deposition disease (requires alizarin stain to see crystals)

37
Q

What underlying malignancy may be associated with HSP in adults?

A

MDS

Internal Medicine (12 decks)

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