Rheumatology

Question 1

Behçet’s disease

Answer 1

• vasculitis
• mouth and genital ulcers
• skin lesions especially ERYTHEMA NODOSUM
• eye lesions

Renal involvement and haematological changes less likely

Question 2

What are the features of CREST syndrome?

also known as limited cuteness system sclerosis

Answer 2

CREST
C- calcinosis
R- Raynaud;s
E - oesophageal dysmotility –> dysphagia
S - sclerodactyly
T - telangiectasia

Question 3

What antibody is associated with CREST syndrome (limited cutaneous scleromderma)?

Answer 3

anti-centromere antibody

(Anti nuclear antibody is positive as well but not specific)

Question 4

What are the features of systemic scleroderma?

Answer 4

CREST symptoms AND systemic involvement - heart, lungs, renal

Question 5

What antibody is associated with systemic scleroderma?

Answer 5

anti-topoisomerase antibodies such as anti-scl70

Question 6

Polymyalgia rheumatica

Answer 6

• age > 50
• bilateral shoulder or pelvic girdle aching and stiffness
• morning stiffness >45 minutes
• high ESR or CRP

CK is normal

Question 7

Polymyositis

Answer 7

Muscle WEAKNESS
HIGH CK levels
Anti-jo antibody positive
Diagnosed by muscle biopsy