Rheumatology

Question 1

Which antibodies in SLE are associated with neonatal heart block

Answer 1

anti Ro

Question 2

mechanism of action of tocolizumab

Answer 2

I’ll 6 inhibitor

Question 3

MOA rituximab

Answer 3

anti CD20

Question 4

name a ctla4 Ig

Answer 4

abatacept

Question 5

what is main killing mode for neutrophils

Answer 5

phagocytosis through opsonisation

Question 6

what is mainstay of treatment in dermatomyositis

Answer 6

prednisolone. anti mi 2 antibodies

Question 7

antibodies in polymyositis

Answer 7

anti jo

Question 8

Treatment of GPA

Answer 8

cyclophosphamide

Question 9

Antibodies in GPA

Answer 9

Anti Pr3 (c-anca)

Question 10

Sx of GPA

Answer 10

Sinusitis then collapse nasal bridge

Question 11

Treatment GPA

Answer 11

High dose corticosteroids then cyclophosphamide

Question 12

Antibodies for microscopic polyangitis

Answer 12

MPO
pANCA

Question 13

Chrug strouss, PANCA or cANCA

Question 14

Tx psoriasis with a) skin involvement b) without

Answer 14

A) Methotrexate
B) SSZ

Etanercept (tnfalpha) if inefficient

Question 15

Felty syndrome?

Answer 15

Ra, neutropenia, splenomegaly

Question 16

Antibodies for GPA

Answer 16

PR3 (cANCA)

Question 17

Use of anti il-2

Answer 17

renal cell carcinoma

Question 18

Example of il-6 inhibitor

Answer 18

Tocoluzimab

Question 19

Antibody in polymyositis

Answer 19

Anti Jo

Question 20

Antibody in PBC

Answer 20

ANTI MITOCHONDRIAL

Question 21

Ab in AI HEPSTITIS

Answer 21

ANTI smooth muscle

Question 22

What is c anca associated with

Answer 22

gpa

Question 23

What is p anca associated with

Answer 23

eGPA, PSC

Question 24

What worsens graves eye disease

Answer 24

Radioiodine

Question 25

Anti lmk-1 antibodies

Answer 25

T2 AI hepatitis

Question 26

Anti mitochondrial antibodies

Answer 26

Primary biliary cholangitis

Question 27

Anti topoispmerase (anti scl-70)

Answer 27

Systemic sclerosis

Question 28

Symptoms of behcets (x3)

Answer 28

Genital ulceration Uveitis Oral ulceration

Question 29

Tx of bechets

Answer 29

Prednisone Azathioprine steroid sparing

Question 30

How does cinacalcet reduce calcium in teriary hyperparathyroidism

Answer 30

Cinacalcet directly lowers parathyroid hormone levels by increasing the sensitivity of the calcium sensing receptors to activation by extracellular calcium, resulting in the inhibition of PTH secretion.

Question 31

What can be used as tumour marker for medullary thyroid cancer

Answer 31

Calcitonin

Question 32

what DMARD for psoriatic arthritis

Answer 32

methotrexate SSZ alternative when not tolerated TNF alpha when at least one DMARD attempted eg etanercept

Question 33

lupus nephritis treatment

Answer 33

Mycophenolate mofetil

Question 34

tx of idiopathic membranous nephropathy with worsening prteinuria and renal function

Answer 34

cyclophosphamide and pred

Question 35

what associated disease is anti scl70 associated with (in addition to diffuse sclerosis)

Answer 35

pulmonary fibrosis ANA is very sensitive but not specific RNA polymerase III associated with skin involvement

Question 37

Anti Jo ABs

Answer 37

Polymyositis

Question 38

Anti mi 2

Answer 38

Dermatomyositis

Question 39

Tx reactive arthritis

Answer 39

NSAIDS then steroids