Oncology Flashcards
What is the translocation seen in burkitt’s lymphoma
C-myc protooncogene transformation. EBV plays a major role
Where is the RET proto onco gene mutation seen?
MEN 2 syndrome
Where is the RAR alpha gene mutation seen
APML
Which part of the cell cycle does F fluorouracil work on?
S cell. most chemotherapeutic agents are ineffective in G0 –> explains why rapidly growing organs eg GI tract often have significant chemotherapeutic side effects
Which cancer is often associated with TLS after chemotherapy
lymphoma - especially wth high tumour burden
What biochemical abnormalities are expected to be seen in TLS
hyperphosphataemia, hypocalcalcaemia and hyperuricaemia (very acidic urine)
What are the most common cancers to metastatise to bone
bone, prostate, breast, MM, and NHL
What conditions could make people suitable for resection of liver tumour over liver transplantation in HCC
no portal hypertension, small tumours (<3 under 5cm), still drinking alcohol,
what is standard chemotherapy for SCLC
etoposide and cisplatin. vinorelbine and cisplatin are used in NSCLC
what is the size limit of a microprolactinoma
<10mms
what carcinomas produce ACTH?
adrenal adenomas, medullary thyroid carcinomas and pancreatic islet cell carcinomas
what is triad of raised beta hcg, chest lesion and testicular lump suggestive of
testicular seminoma
What disease does LEMS present with
SCLC
what does gastro intestinal stromal tumours respond particularly well to
TK inhibitors
what is one of the most common sequalae of anaplastic thyroid Ca
airway obstruction
what is the mechanism of methotrexate
dihydrofolate reductase inhibitor
What is the mechanism of action of imatibin
tyrosine kinase inhibitor
what is the commonest lung cancer type in non smokers
adenocarcinoma
what cancer can cryoglobuliaemia present with?
lymphoma (tested by incubated at 4 degrees)
lung cancer most likely to cause hypercalcaemia
squamous (pthrh secreting)
what is moa of cisplatin
leads to cross linking of dna to form adducts
moa doxorubicin
topoisomerase inhibitor
cancers in nfm2
meningiomas, gliomas and bilareral acoustic neuromas
what cell factor is implicated in gist
stem cell factor (c-kit)
