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STEPH BPT 2021 > Rheumatology > Flashcards

Rheumatology Flashcards

1
Q

CPPD features

A

Calcification of wrist, MCP,

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2
Q

Genetics of RA

A

HLA DRB1*0404/01/05

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3
Q

Scoring for RA disease

A

Disease activity score 28
>5.1 is high
<2.6 is remission

Feet not included

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4
Q

Scleroderma renal crisis Ab

A

Anti-RNA polymerase III abs

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5
Q

Cardiac MRI finding SSC

A

Delayed contrast enhancement anteroseptal location

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6
Q

cANCA

A

Proteinase 3

Cytoplasmic staining

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7
Q

pANCA

A

Myeloperoxidase (MPO)

Perinuclear staining

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8
Q

PR3 associated vasculitis

A

GPA

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9
Q

MPO vasculitis

A

EGPA (only 40% positive for ANCA)
MPA
Necrotising crescenteric GN

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10
Q

GPA clinical manifestations

A

URT involvement
Nasal disease
Pulmonary manifestations
Renal

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11
Q

EGPA manifestations

A 
Asthma
Eosinophils 
Mononeuritis multiplex
Renal 
Skin
Pulmonary infiltration
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12
Q

ANCA Vasculitis Rx

A

Non organ threatening involvement

Pred
MTX

Organ threatening

Methyl pred
Cyclophosphamide or Rituximab

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13
Q

Antibody most specific for SLE

A

Anti ds-DNA

specific 87%

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14
Q

Anti RO

A

Sjogrens
SLE

Risk of cutaneous neonatal lupus and congenital heart block

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15
Q

Anti La

A

Sjögren’s syndrome

SLE

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16
Q

Anti SM (smith)

A

Cerebral and renal lupus

Most specific for lupus

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17
Q

Anti U1 RNP

A

MCTD

SLE

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18
Q

Antibody with negative association with lupus/autoimmune disease

A

Anti dense fine speckled 70

Anti DFS70

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19
Q

Mild lupus Rx

A

Hydroxychloroquine
Pred
AZA
MTX

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20
Q

Rx for SLE major organ involvement

A

Cyclophosphamide

Mycophenalate

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21
Q

Genetics with Spondyloarthritis

A

HLA B27
ERAP 1
IL -23R

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22
Q

TNF inhibitors

A

Etanercept
Infliximab
Adalimumab

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23
Q

Best AHTN for urate lowering property

A

Losartan

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24
Q

Risk in pregnancy with Anti Ro

A

Congenital heart block

25
Q

Drug induced lupus

A

Positive ANA

Hydrochlorothiazide 
Terbinafine
Anti TNF drugs 
PPI
NSAIDS
26
Q

Antibody associated with immune mediated necrotising myopathies

A

HMG-CoA reductase antibodies

Often triggered by statin use

27
Q

Antibody associated with Polymyositis

28
Q

Antibody associated with associated with diffuse cutaneous systemic sclerosis

A

Anti-Scl-70 = anti-topoisomerase I

29
Q

Ab associated with renal and neuropsychiatric Lupus

A

Anti-Sm (smith)

30
Q

Ab associated with Goodpastures Disease

31
Q

Ab most associated with dermatomyositis

A

Anti-Mi-2 antibody

32
Q

Most specific Ab for RA

33
Q

Cancer associated with Sjogren’s syndrome

A

Lymphoma

Associated with Persistently high RF

34
Q

CREST

A 
Calcinosis 
Raynauds 
Eosophageal dysmotility
Sclerodactyly
Telengiectasia
35
Q

Systemic sclerosis vs raynauds clinical finding

A

Nailfold capillary changes with SS

36
Q

Anti-Jo association

A

Antisynthetase syndrome

37
Q

Polymyositis Complications

A

Pulmonary
Eosophageal/dysphagia
Cancer

38
Q

Neurostimulation site for PD

A

Subthalamic nucleus

39
Q

Anti-centromere Ab

A

Limited Cutaneous Systemic Sclerosis

40
Q

Complications of Sjogrens

A 
Lymphoma
Tubulointerstitial nephritis
RTA type 1
IPF
Dental
Ophthalmic
41
Q

Triad of sjogrens

A

Dry eyes
Dry mouth
Inflammatory arthritis

42
Q

Diagnosis of Sjogrens

A

Opthalmic staining score
Lip/labial biopsy (minor glands)
Anti ro/la

43
Q

Triggers of scleroderma renal crisis

A

Prednisolone

ACE not protective

44
Q

Features suggestive of septic arthritis

A

WCC >50,000
>75% polys
Cultures positive

45
Q 
Oral ulcers
Genital ulcers
Ovular disease 
Skin lesions 
GI manifestations
Vasculitis

Positive pathergy test

A

Behcets disease

46
Q

Skin manifestations sarcoid

A

Lupus pernio (involves nose/central face, increased risk for pulmonary sarcoid)

Erythema nodosum

47
Q

Most specific finding for PsA

A

Dactylitis

48
Q

Treatment of RA

A

MTX
sulphasalazine
Hydroxychloroquine
Leflonamide

TNF inhibitor
IL-6 inhibitor
JAK inhibitors

Start on NSAID and oral steroids

49
Q

Treatment of dermatomyositis

A

Pred

MTX/AZA for sparing

50
Q

New murmur an APLS/SLE

A

Liberman-sach’s endocarditis

51
Q

Erosive arthritis of 2nd and 3rd MCP joints

A

Haemachromatosis

52
Q

SScl with ILD Rx

A

Mycophenalate

53
Q

Treatment of sarcoid

A

glucocortocoids

54
Q

purpura, abdominal pain, and arthralgia

A

IgA vasculitis (Henoch-Schönlein purpura)

55
Q

High dose steroids and unexplained groin pain

A

Avascular necrosis

56
Q

RA
splenomegaly
cytopaenia

A

Felty Syndrome

Rx: Steroids

57
Q

aminoacyl-tRNA synthetase antibody

A

Antisynthetase

58
Q

Rash findings dermatomyositis

A

Gottron’s papules

Heliotrope rash

STEPH BPT 2021 (17 decks)

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