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STEPH BPT 2021 > IFD 2024 > Flashcards

IFD 2024 Flashcards

1
Q

Bacteria with ESBLs

A

GN aerobic eg E. coli, kleb

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2
Q

Defining feature of ESBL in terms of ABX resistance

A

Resistant to 3rd gen cefalosporin
Eg ceftriaxone ceftazadime

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3
Q

Most common ESBL gene

A

CTX-M

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4
Q

IV choice of treatment for ESBL

A

Carbapenams

Other
Ceftazidime-avibactam

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5
Q

Oral choice of treatment for ESBL

A

Fosfomycin

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6
Q

Only beta lactas (x2) with same oral to IV bioavailability

A

Amoxicillin
Cephalexin

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7
Q

Po=IV bioavailability

A

Metro
Co trimoxazole
Clindamycin
Cipro
Doxy
Rif
Linezolid
Fluconazole
Amoxi
Cephalexin

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8
Q

3 most common candida species

A

Albicans, glabrata, parapsilosis

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9
Q

Side effects voriconazole

A

LFT derangement
Visual SEs
Photosensitivity

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10
Q

Benefit of liposomal ambisome over conventional AM-B

A

Less nephrotoxic
Better CNS penetration
Less infusion related SEs

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11
Q

When shouldn’t evhinocandins eg caspofungin be used

A

CNS and urinary tract infections - less penetration

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12
Q

Mechanism of methicillin resistance

A

Mec-A gene
Encoded PBP2a, which has a poor affinity to all beta-lactam antibiotics

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13
Q

Beta lactam Antibiotics

A

Penicillins
Cephalosporins (1-4)
Carbapenams

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14
Q

Glycopeptides

A

Vancomycin
Teicoplanin

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15
Q

In what situations should daptomycin not be used

A

poor CNS penetration
Inactive against surfactant

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16
Q

vanA vs vanB resistance

A

Van a - resistance to vanc and teicoplanin
Van b - vanc resistance only

17
Q

Gene conferring resistance for ESCAPPM

A

Amp-C

18
Q

Treatment for ESCAPPMs

A

Carbapenams
Ceftazidime-avibactam
Cefepime -rarely

19
Q

ESCAMPPM organisms

A

Enterobacter sp
Serratia sp
Citrobacter freundii and braaki
Acinetobacter sp
Proteus sp (not miribalis)
Providencia
Morgonella morganii

20
Q

Treatment for VRE

A

linezolid
Daptomycin
Tigecycline

21
Q

VACS Organisms (tropical marine bacteria)

A

Vibrio sp
Aeromonas sp
Chromobacterium violaceum
Shewanella sp

All GNB

STEPH BPT 2021 (17 decks)

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