Neurology Flashcards
Mixture of fluent and expressive aphasia
Arcuate fasciculus lesion
Gene mutations PD
GBA (glucocerebrosidase)
Dopamine agonists
Impulse control disorders
Nausea
Ortho static hypotension
Confusion and hallucinations
memantine
amantadine
NMDA glutamate receptor antagonist
Increase dopamine release
Rx: Alzheimer’s
livedo reticularis
Insomnia
leg oedema
blurred vision
Hot cross bun sign
MSA
Humingbird sign
PSP
MSA
Alpha synucleiopathy
Erectile dysfunction
Urinary incontinence
Postural hypotension
Progressive supranuclear palsy
Early falls
supranuear down gaze palsy
Postural instability
Tau protein
Corticobasal syndrome (Parkinson’s plus)
Apraxia
Frontal lobe dementia
SN gaze palsy
Alien limb
Natalizab
Alpha 4 interim antagonist MS RX Selective adhesion molecule inhibitor Decrease in relapse rate PML risk
Almtuzumab
Mab to CD52 (B cells)
MS Rx
Decreased relapse
No PML
ITP
Autoimmune disease
Ocrelizumab
MS treatment
Anti CD20 mAb
Depletes B calls
Fingolimob
MS Rx
Down regulates sphingosine-1-phosphate receptor
Decrease relapse rate
Heart block
PML
Macular oedema
Optic neuritis
Pain on eye movements Decreased acuity Impaired colour vision RAPD Scotoma
Gerstman syndrome
Brodman 39 and 40 near temporal and parietal junction
Left angular and supramarginal gyrus
Dysgraphia
Dyscalcula
Finger agnosia
Basilar syndrome
EOM abnormalities
Dilated pupil
GCS
Staggered course
Anterior spinal artery infarct
Loss of power distally
Loss of temp/pain
Posterior cord unaffected
Causes of lobar haemorrhage
Cerebral amyloid angiopathy
HLA subtype Carbamazepine
HLA B1502 SJS syndrome
HSV encephalitis location
Bilateral temporal
Lambert Eaton syndrome association
50% paraneoplastic
Mainly SCLC
IgG Abs against Ca channels
In Parkinson’s disease excessive amounts of which protein accumulates in the central nervous system
Alpha synuclein
In Alzheimer’s disease excessive amounts of which protein accumulates in the central nervous system?
Tau protein is seen in Alzheimer’s and forms the typical Neurofibrillary tangles
Amyloid