Rheumatoid arthritis Flashcards

1
Q

Define arthritis.

A

Chronic inflammatory disease characterised by potentially deforming polyarthritis and extra-articular manifestations.

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2
Q

What HLA groups are associated with RA?

A

HLA DR-1 and DR-4

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3
Q

How does RA typically present?

A

Symmetrical swollen, painful and stiff joints of the hands (MCP, PIP and wrist) and feet, as well as non-specific symptoms

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4
Q

What may be seen in late-stage RA?

A

Deforming arthropathy.
Rheumatoid nodules
Extra-articular manifestations

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5
Q

What is the best antibody to use in diagnosis of RA? How does this compare to rheumatoid factor?

A

Anti-CCP- more specific but similar sensitivity to rheumatoid factor

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6
Q

What radiological signs may be seen?

A
Erosions
Periarticular swelling
Loss of joint space
Ostopenia
Deformity
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7
Q

What functional rating scales can be used to monitor RA?

A

DAS28

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8
Q

How is the multidisciplinary team involved in the care of RA patients?

A

GP, physio, OT, nurse, specialist, podiatrist

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9
Q

What group of agents are first-line in RA treatment? What are the drugs of choice?

A

DMARDs. Sulfasalazine or MTX

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10
Q

What role do
a) analgesics
b) corticosteroids
have in RA management?

A

a) used as an adjunct- symptomatic relief

b) cover the lag phase of DMARDs, can help acute flares bt avoid long term use

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