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CVS Anat Path > Rheumatic Fever > Flashcards

Rheumatic Fever Flashcards

1
Q

RHD

Aetiology

A

Strep infections

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2
Q

Rheumatic fever

Define

A

An immune response to group A beta haemolytic streptococcal antigens inciting a cross reaction to tissue antigens.

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3
Q

Macroscopic pathology

A

Warty

Firm adherent vegetations on at lines of closure of valve cusps

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4
Q

Microscopic Pathology

A

Valves become vascularised

Fibrinoid necrosis-> granulomatous inflam (Aschoff body)

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5
Q

Macroscopic clinical findings

A

Valve leaflets fused
Valve leaflets thickened
Valve vascularisation
Chordae tendinae shorten + thicken

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6
Q

Complications

A

Atrial fibrillation
Thrombi + embolism
Cardiac failure
Risk of infective endocarditis

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7
Q

Cardiac manifestation

A

Endocarditis
Myocarditis
Pericarditis

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8
Q

Major criteria

Jones

A 
Pancarditis 
Erythema marginatum 
Migratory polyarthritis 
Subcutaneous nodules 
Sydenham chorea
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CVS Anat Path (9 decks)

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