Rheum Flashcards
Kawasaki disease labs
Platelets and WBCs up; hemoglobin down
AST and ALT up
Sterile pyuria
Acute-phase reactants up
Kawasaki treatment
IVIG
Aspirin
Kawasaki complications
Coronary artery aneurysms
Ventricular dysfunction (due to inflammation or lymphocytic myocarditis)
Pericardial effusion –> cardiac tamponade
Langerhans cell histiocytosis treatment
Chemotherapy (prednisone +/- vinblastine)
Desmopressin for diabetes insipidus
Langerhans cell histiocytosis pathogenesis
Macrophages within tissue proliferate and infiltrate:
Lytic bone lesions (skull, femur, others) with overlying skin lesion
Purplish papules, eczematous rash
Pulmonary cysts/nodules
LAD, hepatosplenomegaly
Central diabetes insipidus
Bone pain at night that resolves with NSAIDs in an adolescent suggests…
Osteoid osteoma - small, round hypodensity with sclerotic border on x-ray
Sarcoidosis shows what kind of granulomas?
Noncaseating
Child with gout and inexplicable injuries
Lesch-Nyhan syndrome - hypoxanthine-guanine phosphoribosyltransferase deficiency