Rheum Flashcards

1
Q

HSP- what is it?
4 systems and manifestations involved
Tx

A

IgA Vasculaitis- leukocytoclastic vasculitits- netutrophils
Palpable purpura
Arthritis at knees and joints
Ab- + Heme in stool, intussception
Kidney- Microscopic hematuria and proteinuira
Tx: NSAIDS/steroids (rare to need steroids)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Kawaski

A

4/5
Fever > 5 days
Lymphadenopathy
Rash
Conjuncivitis
Mucosal involvement
Swelling of hands and feets

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Kawaski
8 lab values, need at least 3

A

CRP >3, ESR > 40
WBC >15
Anemia
Platelets > 450
WBC > 10
ALT > 50
Albumim < 3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Juevnile Dermatomyositis

A

Necrosis and inflammation of muscles
Heliotrope rash
Gottron papules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Juevnile Dermatomyositis

A

Necrosis and inflammation of muscles
Heliotrope rash
Gottron papules

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Lyme Arthritis Mechanism

A

direct invasion of the synovium, leading to a chronic cytokine-mediated proinflammatory response

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What sign is bad in Kawaski?

A

Decreased platelets- risk factor for DIC and coronary artery abnormalities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Kawaski treatment

A

IVIG and aspirin (moderate or high dose)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Discharge Kawaski

A

Afebrile for 36-48 hours

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

SLE vs acute rheumatic fever, specifically arthritis

A

SLE- Non migratory
ARF- migratory

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

SLE Neuro complications

A

deliruium psyhosis, seizure, PRES, HTN crisis,

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Why is SLE more susceptible to encapulated organisms?

A

Low complemetn, funcationl asplenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

SLE vs dermatomysotisis rash

A

Malar rash in SLE spares nasolabial folds (does not in DM)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Labs SLE

A

+ANA
Specific ones +dsDNA, anti-smith
Low complement
Autoimmune hemolysis
Leukopenia
Thrombocytopenia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Oligo vs poly juvenile arthritis

A

Oligo- toddlers, -Rf, chronic uveitics
Poly- toddlrs and teens, > 5 joints, + Rf or -Rf

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Systemic JIA

A

Fever daily
Rash
LAD
Hepatomegaly, splenomegaly
Serositis

17
Q

What suggests a chronic inflammatory arthritis?

A

Leg length discrepancy

18
Q

In Oligo juevnile arthritis

A

GEt opthylo

19
Q

Systemic JIA labs

A

Anemia
Elevated inflammatory markers
Elevated ferritin

20
Q

MAS

A

Cytokine storm- activation of macrophages
See in systemic JIA
Anemia, low platelets, high ferritin, low fibrinogen
Transaminitis
Tx; STeroids

21
Q

HLH

A

excessive immune acitvation, cytokine storm
Pancytopenia
Familial, infection (EBV) Cause
Labs: Cytopenias, increase in ferritin, liver dysfunction, seizures, mental status chnge
Tx: SCT, supportive

22
Q

Alpha Thal

A

< 6 months
Microcytic anemia, splenomegalogy, chronic hemolysis