Rheum Flashcards
HSP- what is it?
4 systems and manifestations involved
Tx
IgA Vasculaitis- leukocytoclastic vasculitits- netutrophils
Palpable purpura
Arthritis at knees and joints
Ab- + Heme in stool, intussception
Kidney- Microscopic hematuria and proteinuira
Tx: NSAIDS/steroids (rare to need steroids)
Kawaski
4/5
Fever > 5 days
Lymphadenopathy
Rash
Conjuncivitis
Mucosal involvement
Swelling of hands and feets
Kawaski
8 lab values, need at least 3
CRP >3, ESR > 40
WBC >15
Anemia
Platelets > 450
WBC > 10
ALT > 50
Albumim < 3
Juevnile Dermatomyositis
Necrosis and inflammation of muscles
Heliotrope rash
Gottron papules
Juevnile Dermatomyositis
Necrosis and inflammation of muscles
Heliotrope rash
Gottron papules
Lyme Arthritis Mechanism
direct invasion of the synovium, leading to a chronic cytokine-mediated proinflammatory response
What sign is bad in Kawaski?
Decreased platelets- risk factor for DIC and coronary artery abnormalities
Kawaski treatment
IVIG and aspirin (moderate or high dose)
Discharge Kawaski
Afebrile for 36-48 hours
SLE vs acute rheumatic fever, specifically arthritis
SLE- Non migratory
ARF- migratory
SLE Neuro complications
deliruium psyhosis, seizure, PRES, HTN crisis,
Why is SLE more susceptible to encapulated organisms?
Low complemetn, funcationl asplenia
SLE vs dermatomysotisis rash
Malar rash in SLE spares nasolabial folds (does not in DM)
Labs SLE
+ANA
Specific ones +dsDNA, anti-smith
Low complement
Autoimmune hemolysis
Leukopenia
Thrombocytopenia
Oligo vs poly juvenile arthritis
Oligo- toddlers, -Rf, chronic uveitics
Poly- toddlrs and teens, > 5 joints, + Rf or -Rf