Rhabdomyolysis

Question 1

what is rhabdomyolysis

Answer 1

the end result of any diseas rpocess that causes muscle cell lysis, the muscle cell contents are release into the circulation and cause problems

Question 2

which IC contents of muscle cells are potentially harmful

Answer 2

myoglobin, K, phosphate, urate, creatinine kinase

Question 3

what can cause rhabdomyolysis

Answer 3

trauma, over exertional states, drugs

Question 4

how do over exertional states cause rhabdomyolysis

Answer 4

direct muscle injury

Question 5

which drugs can cause rhabdomyolysis

Answer 5

cocaine, meth, narcotics, diuretics

Question 6

which cellula structure is disrupted in rhabdomyolysis

Answer 6

sarcolemma

Question 7

how does rhabdomyolysis damage the kidneys

Answer 7

massive amounts of myohlobin are filtered through the glomeruli and precipitate obstructing the renal tubules

myoglobin is also nephrotoxic –> tubular cell necrosis

Question 8

what colour does myoglobin turn urine

Answer 8

red bronw

Question 9

does rhabdomyolysis present obviously?

Answer 9

it may eg after trauma, may also be insidious

Question 10

which enzyme is raised in rhabdomyolysis

Answer 10

CK - levels correlate with severity

Question 11

what is the main goal of treatment

Answer 11

prevent complications (mainly renal failure)

agressive rehydration!!!

Question 12

why do we want to rehydrate patients

Answer 12

promote renal clearance of IC muscular toxins that have been released

Question 13

desired urine output

Answer 13

maintain at 200-300 ml/hour