LE, Botulism Flashcards
what is Lambort Eaton Myasthenic Syndrome
auotimmune disorder of the NMJ
what is Lambort Eaton Myasthenic Syndrome commonly assoicated with
Paraneoplastic syndrome - often bronchial carcinoma
which type of bronchial carcinoma is the most commonly assoicated cancer
SCLC
what is a direct risk factor for Lambort Eaton Myasthenic Syndrome
smoking
pathology of Lambort Eaton Myasthenic Syndrome
there are Ab formed against voltage gated calcium channels at NMJ, impariing NM transmission by inhibiting inward Ca current and subseqeuntly ACh release into synpatic cleft
how does the signal given from the NMJ change in Lambort Eaton Myasthenic Syndrome
the minature endplate potential is normal but there are fewer quanta of ACh released by each depolarization (less mepps)
clinical features of Lambort Eaton Myasthenic Syndrome
limb weakness
dry mouth
dilated poorly reactive pupils
where does the weakness affect in Lambort Eaton Myasthenic Syndrome
proximal legs –> arms
hip girdle
facial muscles
what type of gait does weakness in the hip girdle produce
waddling gait
what taste is described in the mouth in Lambort Eaton Myasthenic Syndrome
metallic taste
what is botulism
paralytic illness caused by Clostridium botulinum
where is C botulinum found
soil
gram stain of C botulinum
gram positive, anaerobic bacillus
exists as a spore
how does C botulinum cause paralysis
it prevents ACh release from presynaptic nerve terminal
how can C botulinum be acquired
thorugh mucosa (food and inhalation) or via a break in the skin (wound, iatrogenic, IV drug use)
