Rh system (FSKP) Flashcards
Second most important blood group after the ABO
Rh
ISBT
International Society of Blood Transfusion
The group of red cell antigens with the greatest clinical significance or importance because of its role in hemolytic disease of the newborn and transfusion
Rh system
Rh is discovered by doing..
Blood transfusion
First human example of antibody directed at the D-antigen in a serum of a woman who’s fetus has hemolytic dx of the newborn was reported by
Levine and Stetson
IDENTIFIED the Rh blood group
Karl Landsteiner and Weiner
The red blood cells injected to the guinea pigs/rabbit came from
Rhesus monkey
Result of the rhesus monkey rbcs injected to the guinea pig/rabbit
- 85% of human RBCs were agglutinated -> Rh positive
- 15% were not agglutinated -> Rh negative
Two local celebrities who are Rh negative
Rosana Roces
Jenny de Belen
Human-produced antibody
Anti-Rh
Reported anti-Rh in serum of patient who received blood from Rh positive
Weiner and Peter
He also demonstrated Rh negative
Levine
Anti-rhesus or Anti-Rh produced by animals
Anti-LW
5 antigens or factors comprising the Rh
- Rh
- C
- E
- c
- e
Antigen that is highly immunogenic
Rh
The least immunogenic antigen
e
Non-glycosylated protein; found on red blood cell membrane
Rh-antigen
ABO is found on chromosome no.?
Chromosome no. 9
Rh is found on chromosome?
Chromosome no. 1
Low molecular weight compound - about 174,000
Rh-ag
4 nomenclatures
- Fisher-Race: DCE terminology
- Wiener: Rh-Hr terminology
- Rosenfield and coworkers: alphanumeric terminology
- International Society of Blood Transfusion Committee (ISBT): updated numeric terminology
There are 3 closely linked gene that can be inherited from both parents
Fisher-Race
Fisher-Race antigens
D C E c e
One gene at a single locus of each chromosome controls the entire Rh system
(Rh gene produced at least 3 blood factors)
Wiener
Wiener antigens
- Rho
- rh’
- rh’’
- hr’
- hr’’
Aims to bridge the confusion between Wiener and Fisher-Race
Rosenfield nomenclature
Assigned numbers to the antigens in a chronological order of discovery
Rosenfield nomenclature