Bombay and Discrepancies Flashcards
causes of weak/missing ABO abs
leukemia w/ hypogammaglobulinemia lymphoma w/ hypogammaglobulinemia patients w/ immunosuppresive drugs congenital agammaglobulinemia bone marriw transplant chimerism
categories if ABO discrepancies
weak/missing ABO Abs
weak/missing ABO Ags
plasma/protein abnormalities
miscellaneous prob
leading cause if weak/missing ABO Abs
chimerism (ata)
presence of 2 cell population in an indiv
chimerism
causes of weak/missing ABO Ags
excess BGSSs Hodgkin's disease leukemia acquired B phenomenon Abs to low incidence in antiA and antiB presence of A/B subgroups
causes of plasma/protein abnormalities
Wharton jelly plasma expander ^ fibrinogen ^ globulin plasma cell dysplasia advanced Hodgkin lymphoma
discrepancy in weak/missing ABO Ags
forward typing
discrepancy in weak/missing ABO Abs
backward typing
causes of excess BGSSs
pseudomucinous ovarian cyst
neutralized antiA antiB antisera
possible causes of acquired B phenomenon
carcinoma of the rectum and colon
other disorders of lower GIT
intestinal obstruction
mechanism of acquired B phen by carcinomas
increased int. wall permeability > allow passage of bacterial polysacc > grpA absorbs grpB
significant bacteria in acquired B phenomenon
E. coli serotype o86
causes of miscellaneous problem
cold reactive something
unexp. ABO isoagglu
unexp. ABO alloanti
polyagglutination
types of polyagglutination
T-polyagg
Tn-polyagg
CAD polyagg
polyagg caused by bacterial/viral inf
T-polyagg
microorganism that may cause T-polyagg
pneumococci
C. perfringes
V. cholerae
influenza virus
T antigen is an example of
cryptantigen
what hides T antigens
NANA
polyagg caused by mutations in hematopoietic cells, insuff. addition of sialic acid during RBC maturation
Tn polyagg
autosomal dominant polyagg
CAD polyagg
what is present in CAD polyagg
CAD antigens
CAD antigen gene
Sda
+ with CAD cells are resistant to
P. falciparum
ABO discrepancies may be caused by
any hemolytic disease that cause stress
characteristics of Bombay
absent H gene all antibodies present absent alpha 2 L fucosyltransferase present A & B enzymes in serum/RBCs strong reactivity with anti-I
types of antiH produced
produced by Bombay
produced by cold agglutinins
which type of antiH is potent
by Bombay
categories of Bombay phenotype
RBC-H deficitent NS
RBC-H partially deficient NS
RBC-H deficient secretor
