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Blood Banking > Bombay and Discrepancies > Flashcards

Bombay and Discrepancies Flashcards

0
Q

causes of weak/missing ABO abs

A 
leukemia w/ hypogammaglobulinemia
lymphoma w/ hypogammaglobulinemia
patients w/ immunosuppresive drugs
congenital agammaglobulinemia
bone marriw transplant
chimerism
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1
Q

categories if ABO discrepancies

A

weak/missing ABO Abs
weak/missing ABO Ags
plasma/protein abnormalities
miscellaneous prob

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2
Q

leading cause if weak/missing ABO Abs

A

chimerism (ata)

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3
Q

presence of 2 cell population in an indiv

A

chimerism

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4
Q

causes of weak/missing ABO Ags

A 
excess BGSSs
Hodgkin's disease
leukemia
acquired B phenomenon 
Abs to low incidence in antiA and antiB 
presence of A/B subgroups
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5
Q

causes of plasma/protein abnormalities

A 
Wharton jelly
plasma expander
^ fibrinogen
^ globulin 
plasma cell dysplasia 
advanced Hodgkin lymphoma
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6
Q

discrepancy in weak/missing ABO Ags

A

forward typing

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7
Q

discrepancy in weak/missing ABO Abs

A

backward typing

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8
Q

causes of excess BGSSs

A

pseudomucinous ovarian cyst

neutralized antiA antiB antisera

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9
Q

possible causes of acquired B phenomenon

A

carcinoma of the rectum and colon
other disorders of lower GIT
intestinal obstruction

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10
Q

mechanism of acquired B phen by carcinomas

A

increased int. wall permeability > allow passage of bacterial polysacc > grpA absorbs grpB

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11
Q

significant bacteria in acquired B phenomenon

A

E. coli serotype o86

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12
Q

causes of miscellaneous problem

A

cold reactive something
unexp. ABO isoagglu
unexp. ABO alloanti
polyagglutination

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13
Q

types of polyagglutination

A

T-polyagg
Tn-polyagg
CAD polyagg

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14
Q

polyagg caused by bacterial/viral inf

A

T-polyagg

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15
Q

microorganism that may cause T-polyagg

A

pneumococci
C. perfringes
V. cholerae
influenza virus

16
Q

T antigen is an example of

A

cryptantigen

17
Q

what hides T antigens

A

NANA

18
Q

polyagg caused by mutations in hematopoietic cells, insuff. addition of sialic acid during RBC maturation

A

Tn polyagg

19
Q

autosomal dominant polyagg

A

CAD polyagg

20
Q

what is present in CAD polyagg

A

CAD antigens

21
Q

CAD antigen gene

A

Sda

22
Q

+ with CAD cells are resistant to

A

P. falciparum

23
Q

ABO discrepancies may be caused by

A

any hemolytic disease that cause stress

24
Q

characteristics of Bombay

A 
absent H gene
all antibodies present
absent alpha 2 L fucosyltransferase 
present A & B enzymes in serum/RBCs
strong reactivity with anti-I
25
Q

types of antiH produced

A

produced by Bombay

produced by cold agglutinins

26
Q

which type of antiH is potent

A

by Bombay

27
Q

categories of Bombay phenotype

A

RBC-H deficitent NS
RBC-H partially deficient NS
RBC-H deficient secretor

Blood Banking (7 decks)

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