Rh blood group system Flashcards
2nd most important blood group in transfusion
Rh
Rh antigen is capable of causing
HDFN and HTR
Discovered by
Levine and Stetson
phenotypically related to Rh blood group system
Anti-LW
Persons with extremely low D antigens
Del
parts of D antigen are missing
D mosaic / Partial D
Position of C affects the D
C in trans to RHD
Degree of antigenicity
D > c > E > C > e
antigens were produced by three closely linked sets of alleles
Fisher-Race: DCE Terminology
eg. DCe
multiple allelic genes in single locus
Wiener: Rh-Hr terminology
eg. rh’hr”
z and y represents
C and E together
D, C, E, c, e are represented by Rh 1, 2, 3, 4, 5
Rosenfield: Alphanumeric terminology
eg. Rh 1, 2, 3, 4, 5
adopted 6-digit number for each antigen belonging to blood group system
International Society of Blood Transfusion (ISBT)
eg. 004001
TEST FOR WEAK D
Indirect AHG/Coomb’s test
how is weak D Px reported
patient: typed as Rh (-)
donor: Rh (+)
Rh null associated
Hereditary spherocytosis
antigen present on most D-positive and all C-positive RBCs
•
G
the destruction of the red blood cells (RBCs) of a fetus and neonate by antibodies produced by the
Ab produced by the mother
occurs when maternal IgG attaches to specific antigens of the fetal RBCs
hemolysis
Destruction of red cells
anemia
Increased production of red cells
erythropoiesis
ighly specialized prenatal test in which a sample of the baby’s blood is removed from the
umbilical cord for testing.
cordocentesis
volume of fetal blood that can immunize the mother
1 ml
