Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Blood Bank - review > ANTIGENS AND ANTIBODIES > Flashcards

ANTIGENS AND ANTIBODIES Flashcards

1
Q

substances that INDUCE the FORMATION of antibodies

A

Antigens

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

part that interacts with antibodies

A

Epitope

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

most antigens in the various blood group systems are inherited _____

A

codominantly

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

antigens classified as either:
1)
2)

A

Low incidence

High incidence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Private/Family antigen
(eg.Kell antigen (K)
1% of population; not common

A

Low incidence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Public antigen
(eg. Cellano (k)
occur in greater than 99% of population

A

High incidence

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

most common antibody detected in Blood Bank

A

Anti-K (anti-Kell)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

STIMULATES plasma cells to PRODUCE ANTIBODIES

A

Epitopes

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

reagent antibodies are termed as:

A

antisera

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

is a mixture of antibodies that target multiple epitopes of a single antigen

A

Polyclonal antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

antibodies that are specific for a single epitope of a single antigen

A

Monoclonal antibodies

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Monoclonal antibodies are produced/made by

A

Kohler and Milstein by using Hybridoma technology

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

antibodies that are found in individuals with no previous exposure to RBC antigens via transfusion, injection, or pregnancy and are produced in response to substances in the environment that resembles RBC antigens

A

Naturally occuring

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Naturally occuring antigens are usually ____ in nature

A

IgM

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Naturally occuring or IgM antibodies react best at

A

room temperature (22 - 25’C) or lower

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

antibodies found in individuals who have been transfused or pregnant

A

Immune antibodies

17
Q

immune antibodies are usually ___ in nature

A

IgG

18
Q

Immune antibodies or IgG react best at

A

37’C

19
Q

Blood groups that are IgG

A

Rh, Duffy, Kidd, Kell, Ss

“DR. KELL IgG on KiddSs”

20
Q

Blood groups that are IgM

A

ABO, Lewis, MN, P, I

21
Q

produced after exposure to NONSELF

A

Alloantibodies

22
Q

produced in response to SELF antigen

A

Autoantibodies

23
Q

Potentiators/Enhancement Media

A

1) AHG (Antihuman Globulin)
2) 22% Albumin
3) LISS (Low Ionic Saline Solution)
4) PEG (Polyethylene Glycol)
5) Enzymes

24
Q

potentiators:

cross-links sensitized cells

A

AHG

25
Q

potentiators:

Reduces RBC surface charge, destroys or enhances RBCs

A

Enzymes

26
Q

potentiators:

macromolecules allows CLOSER contact of antibody-coated cells

A

22% Albumin

27
Q

potentiators:

REMOVE WATER molecule surrounding RBCs to concentrate the antibody

A

PEG

28
Q

potentiators:

reduces ZETA POTENTIAL and increase antibody uptake

(incubation time from 30-60 mins to 10-15 mins)

A

LISS

29
Q

LISS contains

A

0.2% sodium chloride

30
Q

enzymes that breaks the J-chain of IgM antibody

A

DTT & 2-ME

31
Q

enzyme that lets IgG dissociate from RBCs

A

ZZAP

32
Q

Enzymes used in BB

A

Ficin (fig pant)
Trypsin (pig stomach)
Bromelin (pineapple)
Papain (papaya)

33
Q

blood groups that is Enhanced by enzymes

A

“Rh Kidd PILA”

Rh
Kidd
P1
Lewis
ABO
34
Q

blood groups that is DESTROYED by enzymes

A

“MDX”

MNS
Duffy
Xga

Blood Bank - review (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions