RH BLOOD GROUP SYSTEM Flashcards
What ISBT does RH blood group system belong?
ISBT no. 004
They discovered the RH antigen in serum of obstetrical patient who received blood transfusion from her husband after delivering a dead baby.
Levine and Stetson
Rh antigen was named by these two
Landsteiner and Weiner
Rh antigen was discovered in which type of animal?
Rhesus Macaque monkey
What is the difference between RH positive snd RH negative?
RH positive- has the presence of D antigen (D)
RH negative- absence of D antigen (d)
In this terminology, each Rh genes are inherited from each parent as a set of 3 closely linked sets of alleles
Fischer-Race Terminology
In this terminology, each Rh gene encodes for an agglutinogen that contains a series of 3 blood factors/antigens
Wiener Terminology
Rh genes are always expressed as?
Codominant
Wiener terminology is also known as
Rh-Hr Nomenclature
DCE nomenclature is used for what terminology?
Fischer-Race Terminology
It is also known as the Alpha-Numeric Nomenclature
Rosenfield & Coworkers Terminology
ISBT Terminology is also known as
Numeric Nomenclature
Which chromosome do RHD and RHCE genes belong?
Chromosome 1
Which chromosome do RHAG/X1r genes belong?
Chromosome 6
It is the regulator type of Rh null
XOr
It is the Rh mod phenotype which partially suppress antigen expression
XQr
Silent type of Rh null
little r double bar
What are the 2 types of RH Null Phenotype
Silent and Regulator Type
It is a type of Rh Null Phenotype in which it is due to the inheritance of little r double bar
Silent Type
Regulator type of Rh null is due to the inheritance of what gene?
XOrXOr
Hemoglobin and Hematocrit is _________ in Regulator type
Decreased
Bilirubin and Hemoglobin F is _________ in Regulator type
Increased
What type of antigen expression has small amount of D antigen with missing parts of fragments
Du Type
Du Type expresses as Rh Negative
T or F
False
Du Type is Rh positive and needs to be tested by AHG Test to demonstrate presence
Causes/Mechanisms
Genetic Weak D
C-trans
Mosaic/Partial D/D variant/Categories of D
Del Phenotype
Most Rh antigens react in what temperature?
37C
What Immunoglobulin is Rh antibodies mostly related
IgG
It is the most immunogenic type of antigen
D antigen
How many days do Rh antibodies be produced after primary exposure?
120 days
How many days will Rh antibodies be produced after secondary exposure?
2-7 days
Do Rh antibodies bind to complement?
No, because it needs 2 IgG immunoglobulins to attach in an RBC close proximity
