OTHER BLOOD GROUP SYSTEM: WARM ACTING Flashcards
In Private settings what type of incident is present?
High Incident
What antigens are related in High Incident groups?
k (cellano)
e
What antigens are related in Low Incident groups?
K (cell)
What type of Ig is clinically significant because of the association with decreased RBC survival
IgG
What type of Ig is not clinically significant as it does not cause red cell destruction
IgM
What are the functional roles of Other Blood Group system
Glycosyltransferases
Structural Relationship to the RBC
Transport Proteins
Complement Pathway molecules
Adhesion molecules
Microbial receptors
Biologic receptors
What type of RBC cell is related to Gerbich Null
Elliptocytosis
What reagent destroys an enzyme in Kell BGS
Sulfhydryl reagent
What are the 2 most common types of Kell BGS
Kell (Low Incident)
Cellano (High Incident)
Which Chromosome is Kell BGS located in?
Chromosome 7
Kell antigens can be destroyed by which reagent
Glycine-acid EDTA
Where does Kell antigens covalently linked?
Kx antigen (019)
No expression of Kell antigens is called?
Kell Null
What Ig react well in AHG Test of Kell BGS
IgG
What type of antigen is most common in Kell BGS due to its immunogenicity?
Anti-K
Which chromosome does Kx antigen located?
Chromosome X
T or F
Kx antigen is bound directly to red cell, and helps in binding Kell to red cell
True
What are the 3 antigens of Kidd BGS
Jka
Jkb
Jk
In which chromosome is Kidd BGS located
Chromosome 18
Which Jk phenotype is most common in Filipinos
Jk Null
Jk (a-b-)
Kidd Antigens are believed to be _________ Transporter
Urea
Kidd antigen is well developed on how many days
11 weeks
Kidd antibodies binds to complement
T or F
True
Kidd antibodies are the most common cause of what type of disease?
Hemolytic Transfusion Reaction
What bacteria have Jkb-like specificity that may interfere with the result of tests
Micrococcus and Enterococcus faecium
This bacteria produces autoanti-Jkb
Proteus mirabilis
This enzyme together with sulfhydryl reagent can destroy Duffy antigens
Papain and Ficin
Duffy BGS is located in which chromosome?
Chromosome 1
What are the 2 types of antigen in Duffy BGS
Fya and Fyb
What is the phenotype of persons resistant to malaria for Duffy BGS
Fy (a-b-)
What Duffy antigen is resistant to enzymes?
Fyb and Fy3
What Duffy antigen is the receptor of P. vivax and P. knowlesi
Fy6
Duffy antibodies has no immediate cell lysis hence;
not capable of complement binding
What Duffy antigen will not be invaded by P. vivax and P. knowlesi
Fya and Fyb
What are the 2 types of Lutheran antigen
Lua and Lub
What are the obsolete type of Lutheran Antigen
Lu10 and Lu15
How many antigens are there in Lutheran BGS
20 + 2 obsolete
It is the silent gene of Lutheran BGS
Lu gene
It is the regulator gene of Lutheran BGS
In(Lu) gene
