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IMMUNOHEMA REV > RH Blood Group System > Flashcards

RH Blood Group System Flashcards

1
Q

ROUTINE RH TYPING
Detects:_______
Specimen:____________
Rgt:________
Result:_____

A

Detects: D antigen
Specimen: Whole Blood
Rgt: AHG Anti-B (antisera)
Result: Agglutination - Rh negative
No agglu - Rh positive

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2
Q

WEAK D TYPING (Du)
A form of: _________
Specimen: __________
Rgt: _________
Result: _________

A

A form of: IAT
Specimen: whole blood / RCS( neg control: bovine albumin)
Rgt: AHG
Result: Agglu- weak D pos reported as Rh pos
No Agglu- Rh neg

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3
Q

Blood recipients with the C trans weak D, genetic weak D have complete Ag and cannot reproduce allo-anti D. What can be transfused?

A

Rh positive blood

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4
Q

All Rh negative, weak D negative obstetric patients are candidates for _____

A

Rh immune globulin

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5
Q

It si a purified Anti D prepared from immunized donors and GIVEN TO D- NEGATIVE MOTHERS to prevent formation of anti-D

A

RhIg ( RhoGAM)

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6
Q

Lacks ALL Rh antigen on their RBCs

A

Rhnull syndrome

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7
Q

A mutation on RHAG gene and can pass through normal genes of children

A

Regulator type Rhnull syndrome

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8
Q

Mutation in each RHCE gene and the common deletion of RHD gene

A

Amorphic type Rhnull syndrome

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9
Q

Partial suppression of RH gene expression caused by mutations of RHAG gene

A

Rhmod phenotype

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10
Q

Differentiation of ABO and RH

A
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11
Q

Reaction phase of RH

A

37C at IAT PHASE

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12
Q

Antigen composition of Rh blood group

A

Nonglycosylated proteins

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13
Q

Antibody produce by injecting rehuses monkey rbc’s I to guinea pigs and rabbits, having the same specificity as the antibody Levine and Stetson decribed

A

Anti-LW

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14
Q

Reacts:
strongly - D- positive RBCs
Weakly - Rh neg RBCs
Never - Rhnull cells

A

Anti-LW

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15
Q

Most immunogenic Rh antigen.

A

D

Most immunogenic :D>c>E>C>e: least

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16
Q

Present of 85% of whites, and a higher percentage of blacks, American, indians and Asians.

A

D antigens

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17
Q

A nomenclature that based on postulated genetic mechanism of Rh antigen

A

Fisher race / DCE and Wiener /Rh-Hr

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18
Q

A nomenclature that describes the presence or absence of antigen

A

Rosenfield/ Alphanumeric terminology

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19
Q

Antigens were produced by THREE CLOSELY LINKED SETS OF ALLELES

A

Fisher Race/ DCE terminology

20
Q

Codes for the presence or absence of D antigen. Located at chromosome 1.

A

RHD

21
Q

Codes for the expression of Cc andEe antigens. Located at chromosome 1.

A

RHCE

22
Q

Produced Rh associated glycoprotein.
Considered as CO-EXORESSOR.

A

RHAG

23
Q

Denotes absence of D

A

d

24
Q

Postulated that Rh gene produced AGGLUTINOGEN which contains AT LEAST 3 BLOOD FACTORS, each factor an antigen.

A

Wiener:Rh-Hr terminology

25
Q

A substance that stimulates production of agglutinin thereby acting as an antigen.

A

AGGLUTINOGEN

26
Q

Complement of genes inherited form either parents

A

HAPLOTYPE

27
Q

Gene association:
Dce -
DCe -
DcE -
DCE -
dce -
dCe -
dcE -
dCE -

A

Dce - Rh0
DCe - Rh1
DcE - Rh2
DCE - Rhz
dce - rh
dCe - rh’
dcE - rh’’
dCE - rhy

28
Q

System that assigns number to each antigen. No genetic basis.

A

Rosenfield/Alphanumeric terminology

29
Q

Adopted a six digit number for each authenticated antigen binding to a blood group system

A

International society of blood transfusion committee: Updated numeric terminology

30
Q

Haplotype frequency in black, white, and Asians.

A

Black: Ro>r>R1>R2
White: R1>r>R2>RD
Asians: R1>r>R2>Ro

31
Q

Importance of Rh terminologies

A
  • parentage studies
  • predicting potential of HDN
32
Q

Main function of Rh antigen.

A

-Transport of ammonia and carbon dioxide
-maintain the structural integrity of RBC membrane

33
Q

The greatest number of D antigen sites are on cells of the rare Rh phenotype of ________

A

D –

34
Q

Carry only D antigen and completely lack C c and E e

A

D –

35
Q

Cells posses the LARGEST NUMBER OF D antigen sites

A

R2R2

36
Q

Most common D positive genotype

A

R1r

37
Q

Most common D negative genotype

A

rr

38
Q

Inheritance of RHD genes that code for a WEAKENED EXPRESSION OF D ANTIGEN.
Seen frequently in BLACK PERSONS

A

Genetic Weak D

39
Q

Position effect or gene interaction effect.
They can receive D positive RBC’S with no adverse effects.

A

C in trans to RHD

40
Q

D antigen expression can be weakened when ONE OR MORE D EPITOPES WITHIN THE ENTIRE PROTEIN IS MISSING OR ALTERED

A

Partial D

41
Q

Extremely low number of D antigen sites .
Adsorbing and eluting anti- D from individuals red cells.
Relatively common on Asians

A

Del

42
Q

Type positive with anti-D even though the D epitope is on the RHCE protein.

A

D EPITOPES on RhCE protein

43
Q

Results from a hybrid gene RHCE-RHD-RHCE where only a small portion of RHD is on RHCE protein

A

DHAR

44
Q

African descent; amino acid change in the RHce gene

A

ceCF ( Crawford)

45
Q

Identify the detection method of the following:
Genetic weak D: _________
C in trans to RHD: _______
Partial D: _______

A

Genetic weak D: Weak D test
C in trans to RHD: Monoclonal reagents
Partial D: Weak D or Monoclonal

IMMUNOHEMA REV (7 decks)

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