Duffy (008) Blood Group System

Question 1

Duffy is designated by the symbol?

Answer 1

FyFy

Question 2

An antigen that was described by Ukim et al., in the serum of a woman who had three pregnancies.

Answer 2

Fyb

Question 3

Gene location of Duffy

Answer 3

Chromosome 1q ( FIRST HUMAN GENE ASSIGNED TO A SPECIFIC CHROMOSOME)

Question 4

Duffy phenotype that is common on Chinese people.

Answer 4

Fy (a+b-)

Question 5

Most common phenotype in white people.

Answer 5

Fy (a+b+)
Fy (a-b+)

Question 6

Most common GENOTYPE IN BLACKS ( African-American)

Answer 6

FyFy

Question 7

Most common PHENOTYPE IN BLACK (African-American)

Answer 7

Fy (a-b-)

Question 8

Phenotype that can RESIST INFECTION with Plasmodium vivax and Plasmodium knowlesii.

Answer 8

Fy (a-b-)

Question 9

Additional phenotypic markers commonly found in BLACK DONORS that could give a clue to possible presence of silent Fy alleles.

Answer 9

Ro
S-s-
V+VS-
Js(a+)
Le(a-b-)

Question 10

The most important routine blood bank serology in Duffy antigens.

Answer 10

Fya and Fyb

Question 11

Duffy antigens can be found on fetal RBCs as early as how many weeks of gestational age?

Answer 11

6 weeks

Question 12

Duffy antigens has not been found on
______,_______,_______,or _______, but they have been identified in other body tissues including _____,_____,______,_____,_____,_____,____, and ______.

Answer 12

Platelets, Lymphocytes, monocytes, or granulocytes

Brain, colon, endothelium,lung, spleen, thyroid,thymus, and kidney cells

Question 13

Effect of enzyme treatment: Increase or decrease

Answer 13

Decrease

Question 14

Reduce the molecular weight of Fya and Fyb but it does not destroy antigenic activity

Answer 14

Neuraminidase

Question 15

True double dose of Fya (homozygous for Fya)

Answer 15

White donor- FyaFya
Fy(a+b-)

Question 16

Single dose of Fya (heterozygous for Fya)

Answer 16

Black donor - FyaFy
Fy(a+b-)

Question 17

Duffy Antibody that is more frequently encountered in patients with multiple antibodies

Answer 17

Anti Fyb

Question 18

Duffy antibodies immunoglobulin and reaction phase.

Answer 18

IgG and reacts at antiglobulin phase

Question 19

Do not react with enzyme treated cells.

Answer 19

Duffy antigen

Question 20

Duffy antigens reside on a glycoprotein of ___ amino acids that has a relative mass of ___ and two N-glycosylation sites

Answer 20

336 amino acids
36 kD

Question 21

Amino acid at position ___ on the Duffy glycoprotein defines the Fya and Fyb polymorphism

Answer 21

42

Question 22

Fya polymorphism
Fyb polymorphism

Answer 22

Fya: Glycine
Fyb: ascorbic acid

Question 23

Member of the superfamily of chemokine receptors and is known as Duffy antigen receptor of chemokines

Answer 23

Duffy glycoprotein

Question 24

Duffy glycoprotein encoded by what gene at what chromosome

Answer 24

Fy gene
Chromosome 1

Question 25

3 most important alleles at the Duffy locus

Answer 25

Fya Fyb Fy

Question 26

Also called as silent allele and majority of it is seen in black people

Answer 26

Fy

Question 27

Di not express Fyb on their rbc's but express Fyb on other tissues

Answer 27

Fy(a-b-) black

Question 28

Can form anti-Fyb but does not express Fyb on their rbc's and in other tissues

Answer 28

Fy (a-b-) whites

Question 29

Typing of antigens has been performed on the rbc's of chimpanzees, gorillas, and old new world monkeys. The result suggest that _____Fy3 developed first, ___ and that _____ aroese during human evolution

Answer 29

Fy3 Fyb Fya

Question 30

Does not produce a distinct antigen but rather than an inherited weak form of Fyb that reacts with some but not all examples of anti-Fyb

Answer 30

Fyx or Fy(b-)

Question 31

Antigen that is not destroyed by enzyme

Answer 31

Fy3

Question 32

Made by Fy( a-b-) who lack the Duffy glycoprotein

Answer 32

Anti Fy3

Question 33

React with rbc's from all Fy(a-b-) blacks, many Fyb(a+b-) and Fy (a-b-+), but not usually with Fy (a+b+) blacks, and not with whites of any Duffy type.

Answer 33

Anti Fy4

Question 34

React with Fy (a-b-) white but not with Fy(a+)/Fy(b-) Rh null RBCS

Answer 34

Anti Fy5

Question 35

Receptor used by P. Vivax to penetrate RBCs

Answer 35

Fy6 antigen