Lutheran (005) Blood Group System

Question 1

Lutheran gene location

Answer 1

Chromosome 19q

Question 2

How many antigens are present in Lutheran

Answer 2

20 antigens (Lu22,Lu10, and Lu15 are obsolete

Question 3

Have limited evidence that they belong to Lutheran system

Answer 3

Para-lutheran (Lu11,Lu16,Lu17)

Question 4

Four sets of antithetical in Lutheran system

Answer 4

Lua/Lub
Lu6/Lu9
Lu8/Lu14
Lu18 (Aua)/Lu19(Aub)

Question 5

Antigens produces by allelic codominant genes

Answer 5

Lua and Lub

Question 6

Most common Lutheran antigen

Answer 6

Lu(b+)

Question 7

Lutheran antigens are detected on fetal RBCs as early as _________

Answer 7

10-12 weeks of gestation

Question 8

Widely distributed in tissues: brain, lung, pancreas, placenta, skeletal muscle, and hepatocytes.

Answer 8

Lutheran glycoprotein

Question 9

Anti-Lua
Mostly are ______; naturally occurring and __________
Reactive at _______ but few reactive in IAT
CHARACTERISTICS: _______

Answer 9

IgM; Clinically insignificant
Room temp/IS phase
Loose, Mixed-field in test tube

Question 10

Anti-Lub
Mostly____: clinically significant
Reactive at _____
Rare because it is _______

Answer 10

IgG
37’C at IAT phase
HPA

Question 11

The Lutheran antigens are located on____

Answer 11

Type 1 transmembrane protein

Question 12

Lu gene is located on what chromosome

Answer 12

19

Question 13

Rare antibody that reacts with all rbc’s except those testing Lu(a-b-)

Answer 13

Anti-Lu3

• Made only by LuLu individuals (recessive type)

Question 14

RBCs that can be safely transfused to patients with anti-Lu3

Answer 14

Dominant and x-linked type Lu(a-b-)