Revision Questions Flashcards
Which of the following is a common adverse effect associated with long term use of NSAIDs A. Skin rash B. Constipation C. Gastric bleeding D. Nausea and vomiting
Gastric bleeding
Which of the following drugs can be used to treat angina pectoris? A. Prazosin B. Salbutamol C. Glyceryl trinitrate D. Captopril
Glyceryl trinitrate
Monteleukast and zafirlukast are used in the treatment of asthma. Both drugs are examples of: A. Glucocorticosteroids B. Leukotriene receptor antagonists C. Muscarinic antagonists D. Beta-2 agonists
Leukotriene receptor antagonists
Within what time period after the start of a stroke should altepase treatment be started A. . 1 hours B. 12 hours C. 3-5 hours D. 1 day
3-5 hours
Azoles, most commonly used to treat fungal disease, target A. Protein synthesis B. Ergosterol biosynthesis C. DNA replication D. Repair of the cell wall
Ergosterol biosynthesis
The nitrosourea compounds, lomustine and carmustine, are useful because they
A. Cross the blood-brain barrier easily
B. Reduce the ability of cancer cells to grow
C. Block hormone receptors
D. Act if cancer cell metabolism
Cross the blood brain barrier easily
Ionising radiation
A. Damages all cells with no recovery
B. Targets only cancer cells
C. Should only be used as treatment once a month
D. Penetrates all tissues causing damage to cells
Penetrates all tissues causing damage to cells
Angiotensin converting enzyme (ACE) inhibitors lower BP by preventing the
A. Formation of angiotensin 1 from angiotensinogen
B. Breakdown of angiotensin 2
C. Formation of angiotensin 2 from angiotensin 1
D. Stimulation of renin release from the kidney
Formation of angiotensin 2 from angiotensin 1
Which if the following will decrease brain serotonin levels
A. Venlafaxine
B. A low tryptophan diet
C. Minoamine oxidase inhibitors
D. Selective serotonin re uptake inhibitors
A low tryptophan diet, this amino acid is necessary for the synthesis of serotonin
For patients with diabetes, which one of the following is a potential direct complication of injecting insulin A. Hypoglycaemia B. Hyperglycaemia C. Hypertension D. Glaucoma
Hypoglycaemia
Which of the following oral antiemetics is a non-selective antagonist of Muscarinic receptors, and drug of choice for motion sickness? Hyoscine Cinnarizine Prochloropramazine Ondansetron
Hyoscine
Nitrates (nitrovasodilators) A. Administered orally B. Rarely have side effects C. Slow acting D. Rapidly metabolised by the liver E. Can be used as antihypertensive treatment
Rapidly metabolised by the liver
The thrombolytic drug altepase activates the enzyme precursor A. Fibrinogen B. Pepsinogen C. Plasmin D. Plasminogen E. Trypsin oven
Plasminogen
Which of the following drugs is not an NSAID A. Aspirin B. Diclofenac C. Ibuprofen D. Paracetamol E. Piroxicam
Paracetamol
Alkylating agents used in cancer treatment A. Cross-link DNA B. Chemically reduce folic acid C. Cause breakup of DNA in G0 phase D. Inhibit spindle formation E. Block the actions of oestrogen
Cross link DNA
Muscarinic antagonists are effective in the treatment of asthma because they
A. Stimulate adrenergic receptors
B. Are anti inflammatory
C. Stabilise mast cells
D. Dilate bronchioles in asthmatic patients
E. Inhibit release if leukotrienes
Dilate bronchioles in asthmatic patients
Calcium channel antagonists used in the treatment of hypertension can produce adverse effects such as A, nausea B. Vomiting C. Joint pain D. Muscle relaxation E. Ankle oedema
Ankle oedema
Which region of the CNS can detect endogenous toxins of drugs in the blood and initiate the vomiting reflex? A. Hypothalamus B. Cardioaccelatory centre C. Chemoreceptor trigger zone D. Vomiting centre E. Cerebral cortex
Chemoreceptor trigger zone
Carbamazepine, anti epileptic medication also used in analgesia decreases the plasma concerntration of A. Opioids B. Antidepressants C. Antihistamines D. NSAIDs E. General anaesthetics
Opioids
Which of the following drugs stimulates release of insulin from pancreatic B-cells by closing ATP-sensitive K+ channels A. Thiazolidinedione B. Biguanides C. Glibenclamide D. Incretin E. Insulin
Glibenclamide
Typical anti psychotics such as haloperidol may cause A. Bradycardia B. Gastric ulcers C. Dry mouth D. Sedation. E. Diarrhoea
Sedation
A drug which inhibits the biosynthesis of RNA A. Ciprofloxacin B. Cefemenoxime C. Rifampicin D. Streptomycin E. Penicillin D. Trimethoprim
Rifampicin
A drug which interferes with folate synthesis A. . Ciprofloxacin B. Cefemenoxime C. Rifampicin D. Streptomycin E. Penicillin D. Trimethoprim
Trimethoprim
A drug which inhibits protein synthesis A . Ciprofloxacin B. Cefemenoxime C. Rifampicin D. Streptomycin E. Penicillin D. Trimethoprim
Streptomycin
A drug which inhibits the biosynthesis of DNA A. Ciprofloxacin B. Cefemenoxime C. Rifampicin D. Streptomycin E. Penicillin D. Trimethoprim
Ciprofloxacin
The nitrosourea compounds, lomustine and carmustine are useful because they
A. Act on cancer cell metabolism
B. Cross the blood brain barrier easily
C. Reduce the ability of cancer cells to grow
D. Treat hormone-secreting tumours
E. Kill cancer cells in the g0 compartment B phase
Cross the blood brain barrier
Sodium aurothiomalate and auranofin are disease-modifying anti-rheumatoid drugs (DMARDs) that contain which metal? Silver Gold Platinum Magnesium Copper
Gold
A new pill designed to protect against heart attacks and stroke could include any of the following types of drugs except A. Anti hypertensive B. Lipid lowering C. Folate D. Antiplatlet E. Steroids
Steroids
The mechanism of action of statins involves
A. Blocking Na channels
B. Reducing high density lipoproteins in the blood
C. Inhibiting HMG-CoA reductase
D. Reducing the excitability of the membrane
Inhibiting HMG-CoA reductase
Nitrovasodilators such as GTN A. Are rapidly metabolised by the liver B. Are effective in lowering cholesterol C. Are slow acting D. Rarely have side effects
Are rapidly metabolised by the liver
The thrombolytic drug altepase activates the enzyme precursor A. Trypsinogen B. Fibrinogen C. Pepsinogen D. Plasminogen E. Plasmin
Plasminogen
Aggressive treatment if high BP in stroke patients may cause the following problem
A. Patients may suffer liver damage as a side effect of the B-blockers
B. When stopping the drug the BP increases and causes a further stroke
C. Potentiation of asthma in asthmatics
D. Low BP causes blood flow to the brain to fall to a critically low level
E. Patients may feel dizzy
Potentiation of asthma attack in asthmatics
Alkylating agents used to treat cancer A. Block the actions of oestrogen B. Cross-link DNA C. Chemically reduce folic acid D. Inhibit spindle formation E. Cause the breakup of DNA in g0 phase
Cross link DNA
Ciclosporin is used to treat rheumatoid arthritis. Which of the following best describes it's effect on the body A. Anti-inflammatory B. Analgesic C. Local anaesthetic D. Immunosuppressant E. Antibiotic
Immunosuppressant
NSAIDs can block the cox1 and cox2 enzymes - blocking cox2 reduces inflammation, while blocking cox1
A. Affects liver function
B. Reduces swelling in the periphery
C. Blocks prostaglandins that protect the stomach lining
D. Reduces gastric acid secretion
E. Regulates fever
Blocks prostaglandins that protect the stomach lining
Benzodiazepines interact with
A. Noradrenaline receptor sites in the sympathetic nervous system
B. Serotonin metabolism
C. Acetylcholine receptor types in parasympathetic nervous system
D. GABA receptor sites
E. Dopamine receptor sites
GABA receptor sites
Captopril is a drug which blocks the angiotensin-converting enzyme (ACE). It may be used in the treatment of A. Bronchial asthma B. Gastric ulcers C. Cardiac failure D. Anxiety E. Pulmonary embolism
Cardiac failure
Haloperidol is an antipsychotic drug associated with A. Severe sedation B. Severe hypotension C. Serve anticholinergic effects D. Rash R. Gastrointestinal disturbances
Severe sedation
Which blocks the action of angiotensin II by acting on angiotensin II receptors
A. Amlodipine. E. Furosemide
B. Captopril. F. Nifedipine
C. Losartan G. Enalapril
D. Prazosin. H. Bumetanide
Losartan - an angiotensin II receptor antagonist
Which inhibits noradrenaline by a selective action at alpha-1 adrenoceptors
A. Amlodipine. E. Furosemide
B. Captopril. F. Nifedipine
C. Losartan G. Enalapril
D. Prazosin. H. Bumetanide
Prazosin - an alpha blocker
Which acts on the loop of henle in the nephron to reduce Na reabsorption
A. Amlodipine. E. Furosemide
B. Captopril. F. Nifedipine
C. Losartan G. Enalapril
D. Prazosin. H. Bumetanide
Furosemide
Bumetanide
Which inhibits agonist-induced Ca entry into vascular smooth muscle by acting on voltage-sensitive Ca channels
A. Amlodipine. E. Furosemide
B. Captopril. F. Nifedipine
C. Losartan G. Enalapril
D. Prazosin. H. Bumetanide
Amlodipine
Nifedipine
Which inhibits the enzyme responsible for the conversion of angiotensin I into angiotensin II
A. Amlodipine. E. Furosemide
B. Captopril. F. Nifedipine
C. Losartan G. Enalapril
D. Prazosin. H. Bumetanide
Captopril
Enalapril
