Revision- Lung Cancer Flashcards
which transcription factor does lung adenocarcinoma express?
TTF 1 (thyroid transcription factor 1)
which nuclear antigen does squamous lung carcinoma express?
p63
and high molecular wt. cytokeratins (help cells resist mechanical stress)
what is stridor?
wheeze on inspiration
what can cause a hoarse voice in lung cancer?
tumour invasion of LEFT recurrent laryngeal nerve at left hilum
which tumour is at lung apex?
pancoast tumour
muscles waste away e.g. in hand
local invasion of what can cause distended jugular vein?
SVC
puffy eyelids, SVC
what is it called when periosteum becomes inflamed and lift off the bone?
Hypertrophic pulmonary osteoarthropathy
associated with squamous
hypercalcemia is typical of which type of lung cancer?
squamous
SIADH is typical of what?
small cell lung cancer
part cause of hyponatraemia
hyponatremia is typical of what?
small cell lung canecer
what is the most common type of lung cancer?
adenocarcinoma
which lung cancer type is associate with non smokers?
adenocarcinoma
ACTH is associated with which type of lung cancer?
small cell
what is it called when periosteum becomes inflamed and lift off the bone?
Hypertrophic pulmonary osteoarthropathy
joint stiffness, wrist/ ankle pain
ADH is associated with which type of lung cancer?
small cell
cushings is associated with excretion of what/ which type?
ACTH
small cell lung cancer
what are the peripheral lung cancers?
large cell
adenocarcinoma
what are the central lung cancers?
small cell
squamous
what is thrombophlebitis?
blood clot formation
common sites of primary lung cancer metastases?
- Brain
- Liver
- Adrenal
- Bone
- Lymph nodes
commonest cause of mesothelioma?
asbestos
(chrysotile asbestos fibres)
how is mesothelioma diagnosed?
histology from thoracoscopy
mesothelioma management?
pleurodesis
drain
long term pleural catheter
