Review: Cell Mediated and Humoral Immunity-----------Cell-mediated immunity Flashcards
What is the main category of lymphocyte in this branch of the immune system? (T-cell or B-cell?)
Main cell: T-cell
What cell presents Ag to Cytotoxic T-cell cells?
APC (antigen presenting cells) presents Ag to immunocompetent TC-cell (Cytotoxic T-cell) in lymph node
In what MHC receptor is Ag presented to Cytotoxic T-cells? (MHC I or MHC II)
MHC I
In what MHC receptor is Ag presented to Helper T-cells? (MHC I or MHC II)
MCH II
Where does the presentation of Ag to T-cells occur for the first time? (at infection site or in a lymph node?)
T-cell interacts directly with Ag marked cell (altered MHC receptor on infected human cell)
Can T-cells recognize Free Ag or does it always have to be presented in an MHC receptor?
No. It can’t do the free
Why are Helper T-cells necessary in the final activation of Cytotoxic T-cells?
Because it has to be told to differentiate to make army
What chemical stimulus does the Helper T-cell release to stimulate activated Cytotoxic T-cells to proliferate and form a clone “army”?
Interleukin-2 (IL-2)
What receptor on the infected cell at the infection site is holding foreign antigen to allow Cytotoxic T-cells to recognize the infected cell?
MHC I
What chemical does the Cytotoxic T-cell release that kills the infected cell?
perforin
Can a Cytotoxic T-cell be used again after killing an infected body cell?
TC remains intact and detaches from lysing cell to kill again (until no infected cells remain)
TC commit “suicide” when no signal of infection is received
Are memory T-cells created?
Memory T-cells remain in body for future encounter with same disease
Cell-mediated immunity
Human cell to Human cell interaction
