Review: Cell Mediated and Humoral Immunity------ Specific Immunity Flashcards
Define antigen
Stimulates an immune response
Seen as “non-self”/foreign
Best Ags: proteins or combination protein molecule like glycoprotein
Good Ag: polysaccharide
Not good Ags (alone): lipids, nucleic acids
Define immunogenicity as it relates to reactivity.
Immunogenicity: ability of Ag to stimulate immunity
Ex. Protein Ag is more immunogenic than Lipid Ag
Reactivity: ability of immune system to react with Ag
Ex. The more immunogenic the Ag, the more reactive the immune system
What is immunological tolerance? What happens if it is lost?
Immunological Tolerance: prevents us from rejecting self
If lost we could cause harm to our self and reject our own organs and other fluids needed to keep us functioning and alive.
What is the importance of MHC receptors ?
Major Histocompatability Complex
Located on surface of all body cells (surface receptor)
Cells “fingerprint”
Allows specific immune cells to recognize self vs. foreign
Altered MHC receptors are perceived as foreign and destroyed
Review the Origin of the Immune system.
1
What is the parent cell to all blood cells?
Stem Cell (Bone Marrow)
**Where are T-cells and B-cells made in the human body? Where do they mature?
The T-cells are made and mature in the Thymus
The B-cells are made and mature in the Bone Marow
What is meant by the term immunocompetent?
Immunocompetent
Applies to mature T-cells/B-cells
Genetically primed to react with a specific Ag
Recognition site present even before an encounter with Ag
Where in the human body is central vs. seconday lymphoid tissue?
Central Lymphoid Tissue Thymus T-cells become mature here Bone Marrow B-cells become mature here
Secondary Lymphoid tissues
Lymph nodes
Spleen
Peyer’s Patch