MHC Molecules Worksheet/Review Flashcards

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1
Q

What does the abbreviation MHC represent?

A

Major Histocompatibility Complex

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2
Q

Define MHC receptor:

A

cell surface molecules that present Antigen to T-cells. There are 2 classes: MHC I and MHC II

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3
Q

Where are MHC receptors found on cells?

A

Surface receptors on cell membrane

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4
Q

Do all human tissue cells have an MHC receptor?

A

All nucleated cells (red blood cells do not have a nucleus at maturity and do not have MHC surface receptors)

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5
Q

What cells display MHC I receptors?

A

All nucleated body cells

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6
Q

What 3 cell types display MHC II receptors?

A

In addition to MHC I receptors, B-cells, Macrophages, and Dendritic cells also have MHC II receptors.

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7
Q

What type of antigens do MHC I receptors hold?

A

Endogenous Antigens, internal antigen material: self-antigens or antigen material due to an infection in cell

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8
Q

What type of antigens do MHC II receptors hold?

A

Exogenous Antigens, foreign antigens only never self-antigen material

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9
Q

What T-cell interacts with antigen displayed on MHC I receptors?

A

Cytotoxic T-cell

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10
Q

What T-cell interacts with antigen displayed on MHC II receptors?

A

Helper T-cell

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11
Q

Do B-cells interact with antigen displayed on either type of MHC receptor?

A

No, B-cells only interact with free antigens

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12
Q

What does the abbreviation APC represent?

A

Antigen presenting cell

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13
Q

What specific cells are referred to as Antigen presenting cells?

A

B-cells, Macrophages, and Dendritic cells

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14
Q

What specific cell plays a key role in T-cell activation within lymph node?

A

Dendritic cells as they migrate from infection site to lymph node to display antigen on both MHC I and MHC II receptors on cell surface.

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