Review

Question 0

CML indicated treatment

Answer 0

TrK inhibitors: imatinib et al

Question 1

IL-1 inhibition indication

Answer 1

Cryopyric periodic fever (CAPS)

- anakinra

Question 2

Drug eluting stents

Answer 2

Sirolimus, everolimus

Question 3

Enterohepatic processed immuno drugs

Answer 3

Antimetabolites sans methotrexate:
Leflunomide
Azathiopine: 6-MP
Mycophenolate Moffitil: mycophenolic acid

Question 4

Burketts lymphoma

Answer 4

B cell lymphoma, associated with MYC amplification

- associated with EBV (CD40 ligand activation)

Question 5

Aelfacept vs. efalizumab

Answer 5

LFA-3/CD2 (aLeFAcEpt)

LFA-1/ICAM (eflazumab)

Question 6

Hydrocortisone mix

Answer 6

50/50 gluco/mineralocorticoid

Question 7

6-MP vs. azathiopine

Answer 7

Azathiopine is the prodrug

• slow release due to conversion to 6-MP more useful for immuneosuppression
• 6-MP more useful as anti neoplastic

Question 8

Cholestyramine

Answer 8

Interferes with enterohepatic recirculation

Question 9

Adenosine

Answer 9

Anti inflammatory Agents potentially associated with the metabolism of methotrexate
- Inhibits neutrophil activity and phagocytosis of Ig coated particles

Question 10

C677T polymorphism

Answer 10

Altered activity of MTHFR which appears to increase sensitivity to methotrexate

Question 11

Mr. Wegener and his bike

Answer 11

Before he went psycho X, he had a bike and helped kids

Question 12

NFAT

Answer 12

Results in IL-2 txn

Question 13

Tacrolimus Black box warning

Answer 13

Cancer

Question 14

ToKIDSumab

Answer 14

MAb IL-6 inhibitor: treatment of systemic juvenile idiopathic arthritis

Question 15

Amyloid proteins (5)

Answer 15

AL- bence jones
AA- arthritis, inflammation 
Globin- dialysis, big
Trans-thyretenin- familial 
AAPP- post mortem: Alzheimer's

Question 16

1st line COPD

Answer 16

Ipratropium tiotropium

- Quatrenary nonspecific muscarinic agonist