Retinal disorders Flashcards

1
Q

what investigations can be done for retinal disorders

A

fundoscopy
fluorescein angiography
optical coherence tomography
electrophysiology

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2
Q

what does fluorescein angiography do

A

looks at the vessels in the retina

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3
Q

what are the different types of electrophysiology

A

electroretinogram

visually evoked potentials

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4
Q

what does an electroretinogram show

A

measures retinal function

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5
Q

what do visually evoked potentials show

A

records optic nerve function

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6
Q

what can different types of retinal pathology cause changes in

A

visual acuity
visual fields
colour vision
relative afferent pupillary defect (RAPD)

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7
Q

what can cause SUDDEN painless loss of vision

A
Central retinal vein occlusion	
Central retinal artery occlusion		
Ischaemic optic neuropathy		
Stroke					
Vitreous haemorrhage		
Retinal detachment
Sudden discovery of pre-exisiting unilateral loss of vision
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8
Q

what causes central retinal vein occlusion

A

hypertension
glaucoma
hyperviscocity
inflammation

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9
Q

what causes central retinal artery occlusion

A

emboli (carotids/heart)

inflammation

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10
Q

what are the two types of steam optic neuropathy

A

arteritic

non-arteritic

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11
Q

what are the symptoms of giant cell arteritis

A
Headache
Scalp tenderness
Jaw claudication
Neck pain
Nausea/anorexia
Loss of vision
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12
Q

what are the investigations for giant cell arteritis

A

bloods - raised inflammatory markers

temporal artery biopsy

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13
Q

what are the signs and symptoms of optic neuritis

A
Pain on eye movements
Reduced vision
Red desaturation
Central scotoma
Relative afferent pupil defect
Swollen optic disc
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14
Q

what can cause GRADUAL painless loss of vision

A
Cataract
Refractive error
Age-related macular degeneration
Open angle glaucoma
Diabetic retinopathy
Hypertensive retinopathy
Inherited retinal dystrophies
Drug-induced retinopathy
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15
Q

what occurs in age related macular degeneration

A

progressive loss of central vision

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16
Q

what are risk factors for age related macular degeneration

A

age, smoking, poor diet

17
Q

what are the different types of age related macular degeneration

A

dry type

wet type

18
Q

what is seen in dry type ARMD

A

atrophy

drusen

19
Q

what is seen in wet type ARMD

A

neovascular membrane - blood, fluid

20
Q

what is seen on fundoscopic examination of diabetic retinopathy

A
cotton wool spots
exudates
vascular anomalies 
maculopathy
advanced disease
21
Q

what are retinal dystrophies

A

Series of inherited conditions affecting photoreceptor function leading to progressive loss of vision

22
Q

what are the two types of retinal dystrophies

A

photoreceptor dystophies (ERG induced)

Retinal pigment epithelium (EOG induced)

choroid dystrophies

vitreoretinal dystrophies

23
Q

name some photoreceptor dystrophies

A

Retinitis pigmentosa

Cone dystrophy

24
Q

name some RPE dystrophies

A

Best’s vitelliform macular dystrophy

Stargardt macular dystrophy

Sorsby macular dystrophy

North Carolina macular dystrophy

25
name some choroidal dystrophies
Choroideraemia | Gyrate atrophy
26
name some vitreoretinal dystrophies
Stickler syndrome | Congenital retinoschisis
27
what can cause drug induced retinopathy
antimalarias phenothiazines tamoxifen
28
what is a treatment for retinal dystrophy
gene therapy eg involving visual pigment regeneration (rhodopsin)
29
how does gene therapy work
replace the missing or defective gene through viral vector insertion replacent gene synthesises protein
30
give an example of something gene therapy can hep in
choroideraemia