Epilepsy Flashcards

1
Q

what are the differential diagnosis’ of a blackout

A
Syncope
First seizure
Hypoxic seizure
Concussive seizure
Cardiac arrhythmia
Non-epileptic attack
(narcolepsy, movement disorder, migraine)
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2
Q

what would you ask in a history of a blackout patient

A

detailed description of observations before and during attacks
- including level of responsiveness, motor phenomena, pulse, colour, breathing, vocalisation

detailed description of behaviour following attacks

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3
Q

what information might be relevant to diagnosis

A

age

sex

past medical history including head injury, birth trauma and febrile convulsions

past psychiatric history

alcohol and drug use

family history

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4
Q

what is the most common cause of fainting and what causes it

A

vasovagal syncope

loss of consciousness due to a neurologically induced drop in blood pressure

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5
Q

what is the prodrome (pre symptoms) to fainting

A

Light-headed, nausea
Hot, sweating
Tinnitus
Tunnel vision

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6
Q

what can trigger vasovagal syncope

A
Prolonged standing
Standing up quickly
Trauma
Venepuncture
Watching/experiencing medical procedures
Micturition
Coughing
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7
Q

what are the characteristics of syncope

A
upright posture
pallor common
gradual onset
injury rare
incontinence rare
rapid recovery
precipitants common
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8
Q

what are the characteristics of seizure

A
any posture
pallor uncommon
sudden onset
injury quite common
incontinence common
slow recovery
precipitants rare
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9
Q

what are hypoxic seizure and how do they occur

A

seizure caused by lack of oxygen to the brain

Occur when individuals are kept upright in a faint

Can occur in aircraft, at the dentist, when well-meaning passersby help people to their feet….

Patient may have a succession of collapses

Seizure-like activity may occur.

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10
Q

how doe concussive seizures occur

A

after a blow to the head

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11
Q

what can cause cardiac arrhythmias

A

structural cardai abnormalities

functional cardiac problems e.g. long QT syndromes

seizures can also cause cardiac arrhythmias

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12
Q

what are some characteristics of non-epileptic attacks

A
  • more common in
  • women
  • frequent
  • may look bizarre
  • can be prolonged
  • may have a history of other medically un explained symptoms
  • history of abuse
  • “swoon”
  • superficially resemble tonic-clonic seizures
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13
Q

what investigations should be done for a possible first seizure

A

blood sugar
ECG
consider alcohol and drugs
CT head

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14
Q

what advice must be given to a patient after a first seizure

A

copies of safety info

info about the first seizure clinic

enquire about employment - they may need to inform their employer

enquire about potentially dangerous leisure activities

explain driving regulations

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15
Q

what are the driving regulations for a first seizure

A

patient may drive a car after 6 months if their investigations are normal and they have had no further events

may drive an HGV or PSV after 5 years if their investigations are normal, they have no further events and they are not on anti-epileptic medication

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16
Q

when is epilepsy usually diagnosed

A

after a second unprovoked attack

sometimes can be clear on taking a history after a first seizure

17
Q

what are the features suggestive of primary generalised epilepsy

A

no warning

<25yrs

myoclonic jerks - esp first thing in the morning

absences or feeling strange with flickering lights

generalised abnormality of ECG

?family history

18
Q

what are the features suggestive of focal onset epilepsy

A

may get an aura

any age

history of deja vu

rising sensation from the abdomen

episodes where they look blank with lip-smacking and fiddling with clothes

focal abnormality on ECG

MRI may show cause

19
Q

what is an epileptic seizure

A

an intermittent stereotyped disturbance of consciousness, behaviour , emotion, motor function or sensation

believed to result from abnormal neuronal discharges

20
Q

what is epilepsy

A

a condition in which seizures recur - usually spontaneously

21
Q

what are the different groups epilepsy can be classified into

A

Generalised seizures:

  • Tonic-clonic seizures
  • Myoclonic seizures
  • Clonic seizures
  • Tonic seizures
  • Atonic seizures
  • Absence seizures
Focal seizures:
characterised according to
- aura
- motor features
- autonomic features
- degree of awareness or responsiveness 

simple focal and complex focal can evolve into generalised convulsive seizure

22
Q

what investigations can help diagnose epilepsy

A

EEG - for primary generalised

MRI - for patients <50 with possible focal onset

CT - usually adequate to exclude serious cause in >50

video telemetry - if uncertain about diagnosis

23
Q

what are the first line treatments for primary generalised epilepsy

A

Sodium Valproate
Lamotrigine
Levetiracetam

24
Q

what are the first line treatments for partial and secondary generalised seizures

A

Lamotrigine

Carbamazepine

25
Q

what is the first line treatment for absence seizures

A

Ethosuximide

26
Q

what classifies status epileptics

A

prolonged or recurrent tonic-clonic seizures (TCSE)

lasting >30 minutes with no recovery period

27
Q

what are the treatments for status epileptics

A

first line:
lorazepam
midazolam
diazepam

second line:
phenytoin
valproate

third line:
anaesthesia

28
Q

what are the side effects of sodium valproate

A
tremor 
weight gain
ataxia
nausea
drowsiness
transient hair loss
pancreatitis
hepatitis
29
Q

what are the side effects of carbamazepine

A
ataxia
drowsiness
nystagmus
blurred vision
low serum sodium levels
skin rash
30
Q

what are the side effects of lamotrigine

A

skin rash

difficulty sleeping

31
Q

what are the side effects of levetiracetam

A

irritability

depression

32
Q

when is mortality highest in TCSE

A

very young and very old

when secondary to strokes, encephalitis, mass lessons, trauma