Restrictive Lung Disease Flashcards

1
Q

What does restrictive lung disease cause a decrease in

A

Total lung capacity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

2 major categories of restrictive lung disease

A

Intrinsic
Extrinsic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What causes intrinsic restrictive lung disease

A

Lung parenchyma inflammation and scarring

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What causes extrinsic restrictive lung disease

A

Abnormal function of chest wall, pleura, and neuromuscular apparatus

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Which type of restrictive lung disease decreases alveolar-arterial gas transfer, and leads to exudate and debris in lungs

A

Intrinsic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Which type of restrictive lung disease causes impaired ventilator function and respiratory failure

A

Extrinsic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

DPLD

A

Diffuse parenchymal lung diseases

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Is interstitial lung disease a type of intrinsic lung disease or is intrinsic lung disease a type of interstitial lung disease

A

Interstitial is a type of intrinsic

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

3 major interstitial lung diseases

A

Idiopathic pulmonary fibrosis
Sarcoidosis
Pneumoconiosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Are interstitial lung diseases usually common or rare

A

Rare

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Idiopathic pulmonary fibrosis risk factors

A

Smoking
Chronic viral infections
Abnormal acid reflux
Family history

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Why is breathing and oxygen exchange restricted in idiopathic pulmonary fibrosis

A

Scarring/honeycombing of lungs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What causes scarring and honeycombing of lungs in idiopathic pulmonary fibrosis

A

Collagen deposits and fibrotic plaques

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is believed to cause idiopathic pulmonary fibrosis

A

Decreased epithelial cell integrity
Accelerated age associated changes
Exaggerated fibroblast expansion

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What lung changes are caused by idiopathic pulmonary fibrosis

A

Traction bronchiectasis
Alveolar remodelling - collagen + fibrotic plaques
Parenchymal fibrosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Idiopathic pulmonary fibrosis signs and symptoms

A

Exertional Dyspnoea
Clubbing
Dry cough
Bibasilar inspiratory crackles
Restrictive flow volume spirometry

17
Q

DLCO - diffusing capacity of the lungs for CO

A

Quantity of CO transferred per minute from alveolar gas to RBCs

18
Q

DLCO equation

A

Lung surface area available for gas exchange (Va) X rate of capillary blood CO uptake (Kco)

19
Q

How does interstitial lung disease affect DLCO

A

Decrease

20
Q

What chest HRCT findings confirm idiopathic pulmonary fibrosis

A

Reticular changes associated with traction bronchiectasis and honeycombing

21
Q

Recommended Idiopathic pulmonary fibrosis drugs

A

Pirfenidone
Nintedanib
Antacid therapy

22
Q

Pirfenidone

A

Anti fibrotic agent used in COPD treatment

23
Q

Pirfenidone adverse affects

A

GI effects
Photosensitivity
Anorexia
Skin rash
Liver toxicity

24
Q

Nintedanib

A

Tyrosine kinase inhibitor

25
Q

Nintedanib adverse effects

A

Diarrhoea
Weight loss
Liver toxicity

26
Q

Antacid therapy adverse effects

A

Infection
Cognitive function
MI

27
Q

Non pharmacotherapy idiopathic pulmonary fibrosis treatments

A

Pulmonary rehab
Long term oxygen
Lung transplant

28
Q

Sarcoidosis

A

Inflammatory disease causing multi system granulomas due to immune system overdrive

29
Q

Why does sarcoidosis often not require treatment

A

Acute and self limiting

30
Q

Sarcoidosis symptoms

A

Dry eyes
Blurry vision
Enlarged lymph nodes
Hacking cough
Coughing blood
Heart complications
Liver enlargement
Spleen enlargement
Joint pain
Arthritis
Knee swelling
Rashes
Lupus pernio
Erythema nodosum
Skin lesions on back
Subcutaneous nodules

31
Q

What causes sarcoidosis

A

Immune system overdrive

32
Q

Sarcoidosis clinicoradiographic data

A

Bilateral Hilary adenopathy in chest radiograph
Lofgren syndrome

33
Q

Lofgren syndrome

A

Erythema nodosum rash & bilateral hilar adenopathy on CXR +/- fever + arthritis

34
Q

Parts of sarcoidosis diagnosis

A

Biopsy
Clinicoradiographic data
Exclusion of other diagnosis

35
Q

Sarcoidosis drugs

A

Corticosteroids
Methotrexate
Folic acid
Azathoprine
Leflunomide
Mycophenolate

36
Q

Refractory sarcoidosis treatment

A

Infliximab

37
Q

Corticosteroid side effects

A

Osteoporosis
Central adiposity

38
Q

How do corticosteroids improve cpsarcoidosis

A

Decrease pro inflammatory cell survival