Respiratiry Failure Flashcards
What are the 4 stages of the oxygen cascade
Inspired gas - PiO2
Alveolar gas - PAO2
Arterial blood - PaO2
Cell - PO2
What kind of gas exchange occurs in the lungs
Passive diffusion
What factors effect alveolar PO2
Alveolar ventilation
Oxygen consumption
CO2 production
What determines the alveolar to arterial PO2 difference
Shunting
How is normal PaO2 calculated
13.6 - (0.044 x age in yrs) kPa
Shunting
Areas of the lung that are perfused but not ventilated
Factors increasing oxygen transport in blood
Low pH
Incr temp
More 2,3-DPG
incr CO2
What is the difference between type 1 and type 2 respiratory failure
Type 1 just hypoxaemia
Type 2 hypoxaemia and hypercapnic
What O2 and CO2 arterial partial pressures show type 1 respiratory failure
O2 - <8.0kPa
CO2 - normal
What o2 and CO2 arterial partial pressures show type 2 respiratory failure
O2 - <8kPa
CO2 - >6kPa
What type of respiratory failure is caused by lung failure
Type 1
What type of respiratory failure is caused by pump failure
Type 2
5 pathophysiological mechanisms of hypoxaemia
Ventilation perfusion mismatch
Anatomical R-L shunt
Impaired diffusion
Alveolar hypoventilation
Low partial pressure of inspired o2
Reasons for hypoventilation
Increased resistance due to airway obstruction
Reduced compliance of lung tissue or chest wall
Reduced strength of resp muscles
Drugs reducing overall ventilation
Signs of respiratory failure
Tachypnoea
Use of accessory muscles
Nasal flaring
Intercostal recession
Suprasternal recessiom
Tachycardia
Hypertension
Sweating
End organ hypoxia
Cyanosis
Asterixis
Bounding pulse
What causes asterixis and bounding pulse
CO2 retention