Restrictive Disease

Question 1

Physiologic Abnormalities in Restrictive Disease

Answer 1

Reduced Compliance (either chest wall or interstitial problem)
Reduced Airway Resistance

Question 2

Causes of Restrictive Disease (3)

Answer 2

Increased Interstitial Thickness
Increased Lung Water
Increased Alveolar Surface Tension

Question 3

PFTs in Elastic Recoil Restrictive Disease

Answer 3

P-V curve shifted downward and flattened

Reduced DLCO from lower lung volumes and increased septal thickness

Question 4

PFTs in Chest Wall Restrictive Disease

Answer 4

P-V curve shifted downward but slope does not change

DLCO reduced from low volume but corrects w/ VA