Occupational Respiratory Disease

Question 1

3 Determinants of disease location and severity

Answer 1

Dose of exposure: concentration * duration
Solubility: water soluble deposit in upper airway, water insoluble in distal airways
Particle Size: >10um filtered,

Question 2

2 Types of Occupational Lung Diseases

Answer 2

Airway diseases: immunologic asthma (latency), irritant asthma (RADS), emphysema, bronchiolitis.
Interstitial lung disease: pneumoconioses, berrylium, and hypersensitivity pneumonitis

Question 3

Allergic Asthma

Answer 3

High molecular weight antigens cause latent IgE reactions or low molecular weight antigens bind to endogenous proteins to make novel antigens.

Question 4

Important cause of allergic asthma

Answer 4

Isocyanates (paints): join with hydroxyl group to make urethane bond

Question 5

Reactive Airway Dysfunction Syndrome

Answer 5

Single large exposure to antigen produces IMMEDIATE symptoms (24-48 hours)

Question 6

Occupational COPD causes

Answer 6

Coal, silica, biomass combustion, vanadium

Question 7

Cause of occupational bronchiolitis

Answer 7

Inhalation of noxious gases

Question 8

Asbestos Pneumoconiosis

Answer 8

Pink pleura thickening and plaques

Question 9

Silicosis

Answer 9

massive fibrosis from oxygen radicals, very long latency

Question 10

Beryllium disease

Answer 10

granulomatous disease, indistinguishable from sarcoidosis

Question 11

Hypersensitivity Pneumonitis

Answer 11

immune response to animal proteins or dander, contaminated hay most common