Respirology Flashcards
Name 3 side effects of salbutamol
Tachycardia
Hypokalemia
Hyperglycemia
Tremors
During what time period is atrovent helpful in acute asthma exacerbation?
Within first hour
↑ FEV1 by 10% if added to β2 agonist
How long to LABAs last?
12 hours
When do you add LABAs?
Add to ICS if inadequate control with optimal dose
Can LABAs be used in isolation?
NO. Must be used with inhaled steroid (combo inhaler)
Name 3 pathophysiologic mechanisms by which steroids work in asthma?
↓Cytokine production and inhibits various factors in inflammatory cascade.
↓Mediator release for macrophages and eosinophils
Inhibits eosinophil and lymphocyte production
Name 3 side effects of ICS
Oral thrush
Hoarseness
↓linear growth with high dose
What is an indication for adding LTRAs to asthma therapy?
Mild/moderate asthmatics
Allergic asthma
Name 9 signs of good asthma control
Daytime symptoms <4 days/week Night time symptoms <1 night/week Normal physical activity Mild, infrequent asthma exacerbations No absence from school due to asthma Need for fast acting beta 2 agonists <4 doses/week FEV1/PEF >=90% personal best PEF diurnal variation <10-15% Sputum eosinophils (adults) <2-3%
What are the principles of asthma management continuum?
1) Confirm diagnosis
2) Environmental control, education and written action plan
3) B2 agonist on demand
4) Add ICS
5) If >=12 years, add LABA to low dose ICS, if 6-11 years, increase to medium dose ICS
6) If >=12 years, add LTRAl; if 6-11 years, add LABA or LTRA
7) Prednisone or anti-IgA
What dose of fluticasone is considered low, medium and high dose ICS?
Low dose
>=12 years <=250 mcg/day
6-11 years <=200 mcg/day
Medium dose
>=12 years 251-500 mcg/day
6-11 years 201-500 mcg/day
High dose
>=12 years >500 mcg/day
6-11 years >500 mcg/day
Can you develop tachyphylaxis to LABA?
YES
A patient’s asthma is not well controlled. Name 5 next steps in your management.
Assess inhaler technique Ask about compliance Ask about environmental triggers Assess for comorbidities Consider adjuncts
Causes of false negative sweat chloride
- Hypoalbuminemia
- Hyponatremia
- CFTR mutations with preserved sweat duct function
- Insufficient sweat quantity
Name 5 causes of poorly controlled asthma in a patient on ICS and B2 agonists.
Poor medication compliance
Poor technique when administering inhaled medications
Diagnosis other than asthma
Chronic exposure to asthma triggers -Smoke exposure.
Comorbidities such as obstructive sleep apnea
Significant psychosocial impact of asthma on family
Name 3 complications associated with central hypoventilation syndrome
Arrythmias-including sinus pauses
Increased risk of Hirschsprungs
Increased risk of neural crest tumours
Name 4 causes of false positive sweat chloride
- Adrenal insufficiency
- Hypothyroidism
- Anorexia nervosa
- Eczema
- GSD Type I
- Nephrogenic DI
- MPS
- Malnutrition
- Ectodermal dysplasia
Name 3 criteria for the diagnosis of asthma on spirometry
3 ways to diagnose asthma:
- Spirometry
Postbronchodilator increase in FEV1 of >=12%
Reduced FEV1/FVC (<80-90%)
Reduced FEV1 compared to normative values for age
Reduced FEF 25-75
OR
- Peak expiratory flow variability
Increase in peak expiratory flow >=20% post bronchodilator or after course of controller therapy
OR
Diurnal variation
- Positive challenge test
Metacholine challenge
OR
Exercise challenge
challenge
Name 5 causes of declining PFTs in CF
- Allergic bronchopulmonary aspergillosis
- Pulmonary exacerbation
- Non compliance
- CF diabetes
- Viral illness
What is the treatment for ABPA
Oral steroids
Name 2 tests to confirm the diagnosis of ABPA
-Aspergillus skin test
-Elevated total serum IgE concentration (typically >1000 IU/mL)
Others:
-Serum specific Aspergillus IgE
-Eosinophil count
-Precipitating serum antibodies to A. fumigatus
Name 3 organisms that colonize the airways unique to CF
- Staph aureus
- Pseudomonas aeruginosa
- Burkholderia cepacia complex (BCC)
- Aspergillus
Name 2 tests to confirm the diagnosis of ABPA
- Aspergillus skin test
- Elevated total serum IgE concentration (typically >1000 IU/mL)
Others:
- Serum specific Aspergillus IgE
- Eosinophil count
- Precipitating serum antibodies to A. fumigatus
Name 3 bacteria that can cause:
i) epiglottitis
ii) croup
iii) bacterial tracheitis
i) H. flu type B, beta hemolytic strep
ii) parainfluenza, RSV, influenza
iii) staph aureus, strep pneumoniae, h. flu