NICU Flashcards
What tests are in first trimester screening?
Nuchal Translucency
PAPP-A
Beta-HCG
What tests are in second trimester screening?
MSAFP
Beta-HCG
Unconjugated estriol
Inhibin-A
What tests are in 2 step integrated prenatal screen?
PAPP-A and NT at 11-14 weeks
Second trimester quad screen (MSAFP, beta-HCG, unconjugated estriol, Inhibin-A)
Name 10 signs on anatomy scan of aneuoploidy
- Thickened nuchal fold
- Echogenic bowel
- Mild ventriculomegaly
- Echogenic intracardiac focus
- Choroid plexus cyst
- Single umbilical artery
- Enlarged cisterna magna
- Mild pyelectasis(≥ 5 & ≤ 10 mm)
- Short nasal bone
What is NIPT?
Measures cell free fetal DNA in maternal blood
What does NIPT screen for?
Aneuploidy ONLY
When can chorionic villous sampling be performed?
10-13 weeks GA
Name 3 complications of CVS
Higher rate of fetal loss Risk of infection PROM Limb anomalies AMNIO HAS SAME RISKS BUT LESS
What disease cannot be ruled in CVS?
ONTDs
When can amniocentesis be performed?
15-20 weeks
What diseases can be assessed on amniocentesis?
Aneuoploidy (chromosomal analysis) ONTDs (AFP levels Assess fetal lung maturity (L:S ratio>2) Measure bilirubin and acetylcholinesterase TORCH
Name 4 neonatal/postnatal effects of cigarette smoking
Growth restriction Preterm labour Premature ROM Placental abruption SIDS
Name 4 diagnostic criteria of fetal alcohol syndrome
1. 3 Characteristic facial features: A) Short palpebral fissures B) Flat philtrum C) Thin upper lip Others: hypertelorism, flattened face with short nose, bow shaped mouth
- Growth retardation
A) Birth weight or birth length at or below the 10th percentile for gestational age.
B) Height or weight at or below the 10th percentile for age.
C) Disproportionately low weight-to-height ratio (= 10th percentile). - Neurological abnormalities:
Developmental delay, behavioural, LD, brain malformations - Confirmed or unconfirmed prenatal alcohol exposure
Name two infant outcomes in maternal SSRI use
Small increase in cardiac malformations (with paroxetine)
SSRI neonatal behavioural syndrome
PPHN-associated with exposure in 2nd half of pregnancy
Name 3 neonatal effects of maternal cocaine use
Spontaneous abortion
Placental abruption
Prematurity
IUGR
Withdrawal uncommon
Hearing deficits (Abnormal auditory brainstem response)***
Transient abnormal EEG changes
Later-DD, regulation, info processing, LD
Name 10 features of neonatal abstinence syndrome
High pitched cry Irritability Sleep and wake disturbances Hyperactive primitive reflexes Hypertonicity Tremors with resultant skin excoriation Feeding difficulties Vomiting Loose stools Sweating Sneezing Mottling Fever Nasal stuffiness Yawning Failure to thrive
Name 6 features of fetal hydantoin syndrome (phenytoin or carbamezipine use)
Facial: Cleft lip/palate*** Short nose Depressed bridge Mild hypertelorism
Extremities:
Digit and nail hypoplasia***
Other:
IUGR
NOTE: Carbamezipine-increased NTDs
Name 6 features of maternal lithium use during pregnancy
Ebstein anomaly Fetal goitre Hypotonia Arrhythmia Seizures Diabetes insipidus Preterm birth
Name 3 features of maternal phenobarbital use during pregnancy
Cleft lip/palate
Cardiac anomalies
Hemorrhagic disease of the newborn
Name 3 features of maternal valproic acid use during pregnancy
Neural tube defects
Face narrow bi-frontal diameter, elecanthus, anteverted nostrils
Cardiac defects
Long thin fingers/toes
Name 3 features of maternal warfarin use during pregnancy
Optic nerve atrophy
Nasal hypoplasia
Stippled bone epiphyses
What are the neonatal effects of PIH?
Increased risk of mortality IUGR RDS (mixed evidence) BPD Thrombocytopenia Neutropenia NEC Behaviouralproblems Adult-onset cardiovascular disease
What is the definition of hydrops fetalis?
Abnormal fluid accumulation in ≥ 2 fetal compartments •Skin thickening •Fetal ascites •Pleural effusion •Pericardial effusion •(±)Polyhydramnios
Name 10 conditions that can cause with hydrops fetalis
Immune: due to Rh(D) incompatibility (uncommon)
Non-immune:
Hematological
•Feto-maternal hemorrhage, thalassemia, RBC enzyme deficiencies/membrane defects, TTTS
Cardiac
•Congenital heart disease, cardiomyopathy, arrhythmia
Vascular malformation
•AVM, lymphatic obstruction (congenital chylothorax, cystic hygroma)
Infection
•TORCH, Parvovirus B19, congenital syphylis
Genetic
•Aneuploidies, Turner syndrome, Noonan syndrome
Metabolic
•Lysosomal storage disorders, Glycogen storage diseases
Pulmonary
•CCAM, pulmonary sequestration
Name 8 fetal and neonatal affects of maternal diabetes
Still birth
Polyhydramnios
Preterm delivery
LGA/Birth trauma (may be SGA if significant vascular disease)
Transient hyperinsulinism and hypoglycemia
RDS
Congenital heart disease
Transient hypertrophic cardiomyopathy
Polycythemia
Hyperbilirubinemia
Early neonatal hypocalcemia (hypoparathyroidism)
Hydrocephalus
NTDs
Arthrogryposis
Lumbosacral agenesis
Situs inversus
Small left colon syndrome
Renal anomalies (RVT, hydronephrosis, renal agenesis)
Do the majority of babies born to mothers have neonatal lupus?
NO, only 1-2%
Is it possible for healthy mothers to give birth to a baby with neonatal lupus?
YES, 50% of affected babies have healthy mothers
Name 5 features of neonatal lupus
Photosensitive rash
-Disappears (generally without scarring) by 4 months age
Cardiac (heart block, cardiomyopathies)
-At risk almost only when mother Anti-Ro/Anti-La positive
Hepatitis/transaminitis
Cytopenias (anemia, thrombocytopenia)
What is the only permanent sequel of neonatal lupus?
Heart block
Name 10 aetiologies of IUGR
1) Fetal factors
- Genetic/chromosomal abnormalities
- Infection (TORCH)
- Multiple gestation
2) Placental factors
- Uretero-placental insufficiency
- Placental infarcts
- PIH
- Chronic abruption
3) Maternal factors
- Chronic illness
- Drugs/Smoking
- Poor nutrition
List 5 neonatal effects of SGA
Hypoglycemia Hyperglycemia Hypocalcemia Depressed immune function Hypothermia Risk of perinatal asphyxia Polycythemia (with concomitant neutropenia and thrombocytopenia)
What is the definition of twin twin transfusion?
Discrepancy in amniotic fluid volume (NOT weight discordance or Hb)
Does twin twin transfusion happen more commonly in MC/DA or MC/MA pregnancies?
MC/DA
List 5 management options for TTTS?
- Expectant management
- Amnioreduction
- Septostomy
- Selective feticide
- Fetoscopic laser ablation of vascular anastomoses-inc risk of preterm labour
What non-invasive prenatal screening results are suggestive of trisomy 21?
Low AFP
High BHCG
Low estradiol
High inhibin
What non-invasive prenatal screening results are suggestive of trisomy 18?
Everything low! Low AFP Low BHCG Low estradiol Low inhibin
What non-invasive prenatal screening results are suggestive of trisomy 13?
Quad screen not sensitive
Antenatal ultrasounds more helpful
When can NIPT be done?
After 10 weeks GA
What is the advantage of umbilical artery sampling as an invasive prenatal test?
Quick results (within 24-48 hours)
With maternal history of methadone use, how long do you have to watch baby?
10 days
In TTTS, what does the recipient twin have?
Cardiac hypertrophy/myocardial dysfunction/tricuspid regurg/RVOTO
Polycythemia
Polyhdramnios
Increased risk of hydrops
In TTTS, what does the donor twin have?
High output failure Anemia Oligohydramnios Hypovolemia Hypoglycemia Increased risk of hydrops
How do you treat seizures in NAS?
Phenobarbitol
Use AED before morphine
What are two features of a non reassuring fetal heart rate tracing?
Minimal variability (<5 bpm variation around baseline) Late decelerations (uteroplacental insufficiency)
Name 7 causes of fetal tachycardia
Fever (maternal) Arrhythmia Thyrotoxicosis Infection (chorioamnionitis) Medications (e.g. beta-agonists, parasympathetic blockers) Anemia Hypoxia/Fetal distress
What does a sinusoidal FHR tracing indicate?
Anemia
After how many seconds should PPV be initiated for an apneic newborn?
30s
If after initiating PPV HR still <100 after 15 seconds of effective PPV, what is the next step?
M= mask readjustment R= Reposition airway S= suction mouth and nose O= open mouth P= increase pressure A= consider alternate airway
If HR<60 despite 30s of effective PPV what is the next step?
Intubate (recommended before chest compressions in 7th ed NRP)
Chest compressions
What is the IV dose of epinephrine?
0.1-0.3 mL/kg
What is the ETT dose of epinephrine?
0.5 ml/kg
What are the target SO2 recommendations?
1 min 60-65% 2 min 65-70% 3 min 70-75% 4 min 75-80% 5 min 80-85% 10 mins 85-95%
Name the 3 determinants of the need for resuscitation
Term, breathing/crying, good tone
What is the most sensitive indicator of the efficacy of resuscitation?
Increase in HR
At what FiO2 should you start resuscitation in newborns <35 weeks?
21-30%
Name 4 factors other than gestational age that result in favourable outcomes
Female sex
Antenatal steroids
Appropriate EFW
Singleton pregnancy
What are the survival rates for 23, 24 and 25 weeks GA?
- 23 weeks: 36%
- 24 weeks 62%
- 25 weeks 78%
Name 5 risk factors for birth injury
Macrosomia Maternal obesity Abnormal fetal presentation Operative vaginal delivery (Vacuum/Forceps) Cesareandelivery
What is appropriate monitoring for a neonate with subgaleal hemorrhage?
Vitals
Serial HC
Serial Hb
What percentage of patients with brachial plexus injury have residual defects?
20-30% with residual deficits, especially if incomplete recovery by 3-4 weeks
Name 4 situations where non-initiation of resuscitation is appropriate
Confirmed GA <23 weeks
BW <400g
Anencephaly
Confirmed T13 or T18
Above what gestational age is resuscitation nearly always indicated
GA>25 weeks
When should you consider stopping resuscitation?
After 10 minutes if no HR remains detectable
What are the CPS counselling recommendations for 22, 23-24 and 25 weeks GA?
22 week-non-interventional approach
23-24 week-individualized
25-active treatment, except with significant risk factors
Below what gestational age is C/S discouraged UNLESS for maternal indications?
<25 weeks
For what gestational ages should antenatal steroids be given?
All pregnant women between 22 and 34 weeks’ gestation who are at risk of preterm delivery within 7 days (NEW CPS)
What do antenatal steroids reduce the risk of?
↓s mortality from RDS
↓s overall neonatal mortality
↓s need and duration of ventilatory support
↓s need for admission to NICU
↓s incidence of severe IVH, NEC, early-onset sepsis, and developmental delay
Name two appropriate antenatal steroid regimens
- Two 12 mg doses of betamethasone given IM 24 hours apart
2. Four 6 mg doses of dexa- methasone given IM 12 hours apart
What is the difference between caput succudenum, cephalohematoma and sugaleal hemorrhage on exam?
Caput succundum-above periosteum, crosses suture lines, most superficial
Cephalohematoma-subperisoteal, asymmetric, does not cross suture lines
Subgaleal-between perisoteum and aponeurosis, extends from the orbital ridges anteriorly to the nape of the neck posteriorly and to the level of the ears laterally, pallor
What percentage of neonates blood can be lost in the subgaleal space?
20-40%
If there is no recovery by 3 mo or persistent weakness by 5 mo from brachial plexus injury, what intervention is needed?
Suspect rupture of nerve root
Surgical exploration and grafting
MRI may be ordered pre-op to rule out structural anomalies
Name 4 injuries associated with brachial plexus injury
Clavicular fracture
Humeral fracture
Subluxation of c-spine
Facial palsy
In a neonate with brachial plexus injury and no improvement after 4 weeks, what should you do?
Refer to multidisciplinary team ( (neurologists and/orphysiatrists, rehabilitation therapists and plastic surgeons)
In baby born with hornet’s syndrome, what nerves are likely to have be injured at birth?
T1
What nerves are affected in Erb’s palsy and what is the clinical presentation?
C5, C6 Waiter’s tip position (Adduction, internally rotated, pronated) No arm abduction (from shoulder) Can’t externally rotate the arm Can’t supinate forearm Asymmetric moro Absent biceps reflex Preserved arm extension Hand grasp preserved***
What nerves are affected in Klumpkes palsy and what is the clinical presentation?
C7, C8, T1
Isolated hand paralysis and Horner Syndrome
Which brachial plexus injury is most likely associated with horner’s syndrome
Klumpkes
Which type of brachial palsy is most commonly associated with phrenic nerve injury?
Erb’s palsy
What is the treatment for phrenic nerve injury?
- Place on affected side
- Give O2 as needed
- Support feeding (initially IV, then gavage)
- Recover spontaneous in 1-3 months
- RARELY require surgical plication of diaphragm
What is the prognosis for total brachial plexus injury (C5-T1) with phrenic nerve involvement?
Symptoms may be chronic and require surgery
What is the goal temperature in therapeutic hypothermia?
A rectal temperature of 34±0.5°C
When do you start and stop therapeutic hypothermia
Start at age 6 hours
Continue x 72 hours
Name 4 mechanisms by which therapeutic hypothermia works
Decreased loss of high-energy phosphates
Reduced oxygen consumption
Reduction of free oxygen radicals, excitatory NTMs
Reduction in expression of genes causing neuronal cell death
List the criteria for therapeutic hypothermia:
MUST BE Term or late preterm infants ≥36 weeks’ gestation with HIE who are ≤6 h of age and who meet both treatment criteria A and B:
Criteria A evidence of hypoxia: 2 of the following:
- APGAR score < 5 at 10 min
- Continued need for ventilation and resuscitation at 10 min of age
- Metabolic acidosis (pH < 7 or BD > 16 in cord or ABG within 1 hour
Criteria B evidence of encephalopathy
Moderate (Sarnat stage II) or severe (Sarnat stage III) encephalopathy demonstrated by the presence of seizures or at least one sign in at least three of the six categories
Review Sarnat staging
http://www.cps.ca/documents/position/hypothermia-for-newborns-with-hypoxic-ischemic-encephalopathy
What benefit has therapeutic hypothermia been shown to have?
Reduce risk of death/neurodevelopmental impairment at 18-24 months disability
Name 2 complications of therapeutic hypothermia
Bradycardia Hypotension Arrhythmias Thrombocytopenia Edema
Name 4 contraindications to cooling
Severe head trauma Intracranial bleeding >6 hours of age <36 weeks GA Lethal congenital anomalies PHTN/Oxygenation failure (should fix first)
Name 3 pathophysiologic mechanisms that contribute to IVH
Immature capillaries in sub-ependymal germinal matrix
Hemodynamic instability in first few days of life
Inability to auto-regulate cerebral blood flow
Name 3 preventive measures that have been shown to reduce IVH
Antenatal steroids
Post-natal prophylactic indomethacin
Delayed cord clamping
When are the majority of IVHs apparent?
90% within the first week (80% within 3 days)
Name 3 complications of IVH
Post-hemorrhagic hydrocephalus
Periventricular hemorrhagic infarction
Periventricular leukomalacia
What type of cerebral palsy does PVL cause?
Spastic diplegia
Name 10 aetiologies for neonatal seziures
Birth asphyxia/HIE IVH/ICH Infection Stroke CSVT Hypoglycemia Electrolyte imbalances (hypoNa, hypoMg, hypoCa, alkalosis) IEM (present 48-72 hours) Congenital brain malformations Benign neonatal/familial seizures
What investigations would you order for neonatal seizures?
Infection
- CBC, blood culture
- Urine culture
- CSF (inc coxscakie, HSV, entero, CMV, echovirus PCR)
Metabolic
- Glucose
- Na, K, Ca, Mg
- VBG, lactate
- AST/ALT
- Urea
- Ammonia
Neuroimaging
EEG
Name 6 differentials for neonatal hypotonia
Central
- Congenital (e.g. structural brain anomalies, chromosomal defects)
- Acquired/Acute (e.g. infection, HIE)
Peripheral
- Anterior horn cell (e.g. SMA)
- Peripheral nerve (e.g. Charcot-Marie-Tooth)
- Neuromuscular junction (e.g. Myasthenia)
- Muscular (Myopathies, Muscular dystrophies)
Name 3 risk factors for neural tube defects
Lack of maternal folate
Diabetes
Medications (e.g. VPA)
Name 4 external signs of spinal dysraphism
- Dimple
- Sinus tract
- Hemangiomas/Lipomas
- Hair tuft
Name 10 conditions that cause hydrocephalus in a neonate
Non-communicating (obstructive)
1) IVH-Post-hemorrhagic hydrocephalus
2) Aqueductal stenosis (X-linked with adducted thumbs, auto recessive associated with VACTERL)
3) Arnold Chiari/Dandy-Walker Malformations
4) Congenital hydrocephalus
- Infection (TORCH)
- Vein of Galen malformation
5) Intracranial mass
Communicating
1) IVH–>Injury to subarachnoid granulation
2) Meningitis
3) Congenital absence of arachnoid granulation
4) Choroid plexus papilloma (over-production of CSF)
In acquired perinatal HIE, when does the secondary injury occur?
6-72 hours post insult
What are the 4 inclusion criteria for cooling protocol?
- Infants >= 36 weeks GA
- Within first 6 hours of age
- Evidence of intrapartum hypoxia (CPS criteria for cooling)
- Moderate or severe encephalopathy
Name 5 complications of HIE
PPHN Seizures Secondary surfactant deficiency Hypoglycemia ICH ATN
CNS: ICH, Seizures, Stroke, Cerebral Edema, Hypotonia/Hypertonia
CVS: Myocardial ischemia, Poor Contractility, Cardiac Stunning, Tricuspid Insufficiency, Hypotension, Bradycardia, Cyanosis/Pallor
RESP: PTHN, Pulmonary Hemorrhage, RDS
RENAL: ATN, Cortical Necrosis
ADRENAL: Hemorrhage
GI: Perforation, Ulceration with Hemorrhage, Necrosis
METABOLIC: SIADH, Hyponatremia, Hypoglycemia, Hypocalcemia, Myoglobinuria
SKIN: Subcutaneous Fat Necrosis
HEME: DIC
What is the neurodevelopmental outcome in mild, moderate, severe HIE?
Mild-usually none
Moderate-30-50%
Severe-80%
Between what gestational ages are premature babies at most risk for IVH?
23-32 weeks GA
When should the first head ultrasound be done?
Within first 72 hours
Most cases of CP are related to event that occured before labour. T or F?
TRUE
What is the most specific indication?
Abnormal eye movements
Patient with CHF, seizures and hydrocephalus?
Vein of Galen
Child with brachial plexus injury. How long before if no change in exam is prognosis poor?
If incomplete recovery by 3-4 weeks, full recovery unlikely
What is the best way to assess neonatal heart rate?
Ausculatation NOT palpation of umbilicus
How much pressure should be given for PPV of term and preterms?
20-25 cm H20 in preterm
30-40 cm H2O in term
Under what gestational age should babies be placed under a polyethylene wrap + radiant heater?
< 28 weeks
If no resuscitation is required, how many minutes of delayed cord clamping should be done?
1 minute
Tube sizes
<1,000g, <28 weeks-2.5
1000-2000g, 28-34 weeks-3.0
2,000-3,000g, 34-38 weeks-3.0/3.5
Term-3.5/4.0
List one advantage and one disadvantage of T piece resuscitators
Advantage:
- More consistent inflation pressures and PEEP than self-inflating bags or flow-inflating bags
- Can deliver free flow
- Can deliver 100% O2
Disadvantage:
Requires a compressed gas source
List one advantage and one disadvantage of self inflating bag
Advantage:
1. Does not need a compressed gas source
Disadvantage:
- Concentration of oxygen is not consistent unless a reservoir is attached
- Cannot deliver free flow oxygen
- Cannot reliable deliver CPAP
List 5 signs of hypoglycemia
- Jitteriness or tremors
- Apathy
- Episodes of cyanosis, convulsions, intermittent apneic spells or tachypnea
3 Weak or high-pitched cry - Limpness or lethargy
- Difficulty in feeding
List 3 groups at high risk of neonatal hypoglycemia
SGA (weight <10th percentile) LGA infants (weight >90th percentile) IDMs Preterm infants Perinatal asphyxia
When is the physiologic nadir of blood glucose in neonates?
1-2 hours after birth
When should asymptomatic at-risk neonates have their first blood glucose check?
2 hours of age AFTER 1 effective feed
breastfeed or 5-10 ml/kg formula
List 3 indications for IV D10W at TFI 80ml/kg/day as per CPS hypoglycemia protocol
<1.8 mmol/L at 2 h of age
<2.0 mmol/L after subsequent feeding
<2.6 mmol/L repeatedly despite subsequnt feeding
How many minutes after feeding should blood glucose be checked?
60 mins
Unless <1.8, then check in 30 mins
At what GIR should you start considering endocrine/metabolic causes of hypoglycemia
If BG <2.6 at TFI 120 mL/kg/day of 12.5% = GIR 10.4 mg/kg/min
When should you stop screening in LGA?
12 hours of age
When should you stop screening in SGA?
Screen once or twice on the second day of life
Stop by 36 hours of age
List 3 causes of transient neonatal hyperinsulinism
Asphyxia SGA Prematurity Maternal toxemia Infant of diabetic mother
When does congenital hyperinsulinism typically present?
Birth to 18 months of age
What labs are consistent with hyperinsulinism?
Insulin > 2uU/mL Low ketones (< 2.0mmol/L) Low FFA (<1.5 mmol/L)
List 10 components in a critical blood sample during hypoglycemia
Blood glucose Insulin C-peptide Cortisol Growth hormone Lactate Venous blood gas Free fatty acids Total and free carnitine Beta hydroxybutyrate Ammonia Pyruvate Urine reducing susbtances and ketones T4, TSH IGFBP-1
What is the incidence of invasive infection in an initially well-appearing infant with a maternal history of fever or chorioamnionitis?
<2%
How long should you keep a baby with septic risk factors in hospital for observation?
24 hours
What is the cut off weight for LBW and VLBW?
LBW-2500g
VLBW-1500g
List 5 causes of IUGR
Fetal-genetic, congenital infection, fetal strctural anomaly, multiple gestation
Placental-ischemic placental disease, gross placental abnormalities
Maternal-medical conditions, malnutrition, teratogens, assistive reproductive technologies
List 5 complications of IUGR in the neonate
Premature delivery
Perinatal asphyxia, which may be accompanied by meconium aspiration or persistent pulmonary hypertension
Impaired thermoregulation
Hypoglycemia
Polycythemia and hyperviscosity
Impaired immune function-neutropenia
Hypocalcemia
By what age do patients who are small for gestational age usually show catch up growth?
Most have postnatal catch-up growth to normalize their stature by 2 years of age
List 5 causes of polyhydramnios
Anencephaly, Hydrocephalus TEF Duodenal Atresia Spina Bifida Cleft Lip/Palate CCAM, CDH Neuromuscular diseases Achondroplasia KlipelFeil Trisomy 18, 21 TORCH Diabetes mellitus Twin-twin transfusion (recipient) Fetal hydrops - anemia, heart failure, non immune Polyuric renal disease Chylothorax Teratoma
List 5 causes of oligohydramnios
AFV leak, ROM IUGR Fetal Anomalies Twin to Twin Transfusion Renal Agenesis (Potter) Urethral Agenesis Prune Belly Syndrome Pulmonary hypoplasia Amnion Nodosum ACE-I Intestinal pseudo-obstruction
List 5 risk factors for RDS
Maternal DM Multiple gestation Asphyxia C/S delivery without labor Precipitous delivery Male Europenea LBW
List 3 protective factors for RDS
Heroin use
PIH
PROM
Antenatal steroids
List 2 interventions to prevent RDS
- Avoid unnecessary early delivery
2. Give antenatal corticosteroids to moms between 24 and 34 wk GA likely to deliver within 1 wk
List 4 contraindications to indomethacin
Thrombocytopenia Bleeding d/o Oliguria <1 mL/kg/hr ↑ Cr NEC Isolated intestinal perforation
List 3 characteristics of RDS on CXR
Diffuse reticulogranular appearance
Air bronchograms
Reduced lung volume/low FRC
List 3 causes of secondary surfactant deficiency
MAS
Pneumonia
Pulmonary hemorrhage (albumin, meconium and blood inhibit surfactant function)
List 3 benefits of surfactant administration
↓ MORTALITY
↓ morbidity of RDS
↓pulmonary air leaks
↓ length of ventilatory support
↓ hospital stay
↓ cost of ICU treatment
↑likelihood of surviving WITHOUT BPD
Improving survival rather than incidence of BPD
↑ survival WITHOUT ADVERSE NEURO outcomes
List 3 risks of surfactant therapy
- Short-term risks → bradycardia and hypoxemia (during instillation)/ blockage of ETT)
- Risk of pulmonary hemorrhage (RR = 1.47) – BUT reduces mortality from pulm hemorrhage
- Over-distention/hyperventilation with low C02 can occur (d/t ↑ compliance) if ventilation pressures/settings aren’t weaned within minutes (as volume increases you must decrease the pressure)
What is better: natural or synethetic surfacant? And why?
Natural surfactant!
↓ mortality ↓ oxygen needs ↓ need for ventilator support ↓ air leak ↑ survival without BPD
What is the dose of surfactant?
120 mg phospholipids/kg
If infants with RDS have persistent or recurrent O2 (FiO2 > 30%) and ventilator requirements in 72 hours what should you do?
Should have repeated dose as early as 2 hrs but usually 4-6hrs after initial dose of BLES
NO BENEFIT OF >3 doses
After giving surfactant, when should you try to wean from ventilator?
Try to RAPIDLY weanfrom ventilator to CPAP within 1 hour
List 3 indications for surfactant
Preterm:
Intubated infants with RDS
Intubated with RDS before transport
Preterms on non-invasive with FiO2>50%
Term:
MAS requiring >50% 02
If sick newborn with pneumonia and OI >15 (= FiO2*MAP / PaO2)
Intubated with pulmonary hemorrhage leading to clinical deterioration
List 3 pathophysiologic causes of BPD
Alveolar collapse (atelectotrauma) due to surfactant deficiency
Ventilator-induced overdistention (volutrauma)
Oxygen free radicals; cannot be metabolized by immature antioxidant systems of VLBW
Name 2 groups at high risk of developing BPD
BW <1,000 g
<28 wk GA
When can you make the diagnosis of BPD?
Oxygen requirement at 36
weeks postmenstrual
age (PMA)+ respiratory symptoms + CXR abnormalities
What are the benefits of postnatal steroids for BPD?
May ↓ time to extubation
May ↓ risk of BPD
List 3 risks of postnatal steroids for BPD
HTN Hyperglycemia GI bleeding and perforation Hypertrophic cardiomyopathy Sepsis Poor weight gain and head growth Adrenal insufficiency ↑ risk DD and CP (but BPD itself is associated with these as well)
List 3 long term complications of BPD
- Frequent hospitalization
- Increased risk of RAD, PHTN, more severe infections
- Poorer neurodevelopment
List 3 risk factors for esophageal atresia
Advanced maternal age European ethnicity Obesity Low SES Smoking
What % of patients with esophageal atresia have an associated syndrome?
50% syndromic (usually VACTERL)
How does EA present in neonates?
With ++ secretions/bubbling at the mouth and nose after birth
Coughing, cyanosis, and respiratory distress, exacerbated by feeding
How do you diagnose TEF/EA?
contrast esophagram
List 3 complications of repaired TEF/EA
Anastomotic leak
Stricture
GERD (from intrinsic abN of esophageal function)
RAD (often exacerbated by GER)
List 3 risk factors for TTN
Elective CS without labor Prematurity or early term (37-38wk) LGA IDM Twin Male infant Maternal asthma
Describe 3 CXR findings in TTN
Prominent pulmonary vascular markings
Fluid in the intralobar fissures
List 3 risk factors for MAS in patients with meconium-staineed amniotic fluid
Thick MSAF NRFHR Low apgar at 5 min Instrumental delivery Emergent C/S Planned home delivery
List 3 CXR findings consistent with MAS
Patchy infiltrates
Coarse streaking of lung fields
Hyperinflation +/- air leaks
List 4 risk factors for PPHN in a neonate
Birth asphyxia MAS Pneumonia Pulmonary hypoplasia RDS Polycythemia Maternal use of NSAIDS with in utero constriction of DA Maternal late trimester use of SSRI
What is a significant pre/post ductal sat difference?
Gradient between preductal and a postductal ABG >20 mmHg
OR
Oxygenation saturation gradient >5% suggests R–L shunting through the PDA
List 4 interventions to treat PPHN
- Optimizing oxygenation (PaO2) and ventilation
- Intubate ventilate - Sedate if desats with handling/stimulation
- Correct acidosis
- Optimize cardiac function and maintain systemic perfusion with inotropes PRN
- Reduce PVR (iNO if available)
Should you give narcan to an apneic neonate if mother is a heroin addict?
NO
Do not give Narcan to infants of mothers on methadone/heroin-will induce seizures
List 4 ways how meconium aspiration affects lungs
- Mechanical obstruction of airways (ball-valve effect)
- Chemical pneumonitis and inflammation
- Risk of secondary Infection (e.g. GN)
- Inactivation & decreased endogenous production of surfactant
- Ventilation-perfusion mismatch
- Pulmonary vasoconstriction/PPHN
When does apnea of prematurity typically resolve?
36 weeks
Some infants, especially those born ≤28 wks GA, may have persistent apneas at 37-40 wks GA - control of breathing matures in almost all infants by 44 weeks
List 5 clinical features of SSRI neonatal behavioural syndrome
CNS dysregulation (irritability, excess or restless sleep)
Motor dysregulation (agitation, tremor, hyperreflexia, rigidity, hypotonia or hypertonia)
Autonomic dysregulation (hypothermia or hyperthermia, hypoglycemia)
Respiratory symptoms (nasal congestion, respiratory distress, tachypnea)
GI symptoms (diarrhea, emesis, poor feeding)
What is the timeframe of SSRI neonatal behavioural syndrome?
Most infants present within several hours, have mild symptoms that resolve within 2 wk
What percentage of SSRI exposed infants get SSRI neonatal behavioural syndrome?
10-30%
What would you recommend to a mother taking paroxetine during pregnancy?
Consider switching them to another antidepressant or ↓ing dose
How long should you observe SSRI-exposed infants?
Babies with late-trimester SSRI exposure should be observed minimum of 48 h
List 3 effects of maternal depression on the infant
Insecure attachment
Negative affect
Dysregulated attention and arousal.
What areas of the brain are typically affected in kernicterus?
Basal ganglia
Brainstem
Describe the clinical features of Chronic Bilirubin Encephalopathy
Athetoid CP +/- Seizures
Upward gaze paresis
SNHL
Dental enamel dysplasia
List 5 risk factors for severe hyperbilirubinemia
- Prematurity
- Infection
- Infant of Diabetic Mother
- ABO Incompatability
- Hemolytic Disease (e.g. G6PD)
- Hx of sibling receiving phototherapy
- Exclusive breastfeeding
- East-Asian
- Male
What is the cutoff for severe hyperbilirubinemia?
TSB > 340 micromol/L during first 28 days of life
Which infants with hyperbilirubinemia should get G6PD screens?
In at-risk infants (Mediterranean, Middle Eastern, African, Southeast Asian)
In all infants with severe hyperbili
Which infants with hyperbilirubinemia should get intensive phototherapy?
- Infants with severe hyperbili
2. Those at greatly elevated risk of developing severe hyperbili
Which infants with hyperbilirubinemia should get conventional phototherapy?
TSB concentrations 35-50 µmol/L lower than threshold
Which infants with hyperbilirubinemia should get IVIg?
Infants who are DAT+ who have predicted severe disease based on antenatal investigation or high risk of needing exchange
Which infants with hyperbilirubinemia should get supplemental fluids (po or IV)?
Infants receiving phototherapy who are at an elevated risk of progressing to exchange transfusion
List 2 indications for exchange transfusion in hyperbilirubinemia
- TSB above exchange threshold
2. Acute bilirubin encephalopathy
List 5 causes of unconjugated hyperbilirubinemia in the neonate
Isoimmune Hemolytic:
• ABO incompatibility
• Rh incompatibility
• Other group
Non-immune Hemolytic: • Hereditary spherocytosis/elliptocytosis • G6PD • PK Deficiency • Thalassemia
Polycythemia
Hypothyroidism
Cephalohematoma
Crigler Najjar or Gilbert Syndrome
Breastfeeding Jaundice
Breast milk Jaundice
How long does breastmilk jaundice last?
4-12 weeks
After phototherapy, when should you typically recheck bili?
6 hours
4 important questions to ask on history in a neonate with jaundice
- ABO Incompatibility/ Was DAT done?
- Did jaundice start in first 24 hrs?
- Assess for hydration status: What’s their weight (% weight loss from birth weight) and method of feeding?
- Previous sib with severe hyperbili??
When does physiologic anemia happen in preterms and term babies?
8-12 wk in term infants
4-8 wk in premature infants (as low as Hb 80)
What is the Kleihauer-Betke test?
Detects fetal Hb and RBCs in maternal blood
Main diagnostic test used for detection and quantitation of fetomaternal hemorrhage
List the 2 most common causes of hemolytic disease (erythroblastosis fetalis)
- ABO incompatibility (most common, mild, usually only jaundice)
- RhD incompatibility
Explain the physiology of RhD hemolytic disease
When Rh-negative woman are exposed to Rh-positive fetal blood (abruption, trauma during pregnancy, spontaneous or induced abortion or at delivery) antibody formation against D antigen may be induced
List 3 indicators of significant Rh hemolytic disease based on titers during pregnancy
- Elevated antibody titers at the beginning of pregnancy
- A rapid rise in titer
- Titer > 1:64
Describe the clinical features of Rh hemolytic disease
Pallor HSM Cardiomegaly Hydrops fetalis Petechiae, purpura, DIC Hypoglycemia Death in utero
What test is the best indicator of the severity of Rh hemolytic disease?
Cord hemoglobin
List the steps in the management of Rh hemolytic disease
- Intrauterine transfusions
- pRBCs ready at delivery (O -ve, leukoreduced, and irradiated blood)
-IVIG → given early, can reduce hemolysis, peak MBR and need for exchange Tx
-
-Measure Hb, Hct, and serum bilirubin q 4-6 hr intervals
- Photherapy
- Exchange Transfusion → if at risk of severe anemia or jaundice
When is Rhogam given?
28-32 weeks GA and at birth
List 3 complications of exchange transfusion
NEC
Thrombosis
Bradycardia
Infection (CMV, HIV, hepatitis)
Why do neonates receive leukoreduced, irradiated blood?
Irradiated-reduce risk of GVHD
Leukoreduced-reduce risk of CMV
When does classic HDNB typically present and what is it caused by?
Within 1st week
- No vitamin K prophylaxis
- Exclusive breastfed
When does early-onset HDNB typically present and what is it caused by?
<24 hours
-Maternal medications (eg, warfarin, antibiotics; cephalosporins, anticonvulsants: phenobarb and phenytoin)
When does late onset HDNB typically present and what is it caused by?
3 weeks and 8 months of age
- No vitamin K prophylaxis/only one oral dose
- Exclusive breast feeding
- Malabsorption vit K (CF, liver disease)
Which types of HDNB typically present with ICH?
Early onset
Late onset
Classic-usually GI bleedig, skin bruising, bleeding post circumcision
What is the dose of vit K prophylaxis?
- 5 mg (BW < 1500 g)
- 0 mg (BW> 1500 g)
WITHIN FIRST 6 hours!
What is the dose and schedule of po vitamin K prophylaxis?
2.0 mg vitamin K1 at the time of the first feeding
Repeat at 2-4 weeks and 6-8 weeks of age
Still have increased risk of HDNB
What tests can you order in HDNB?
INR/PTT (both elevated in severe vit K deficeincy)
What is the difference between maternal ITP and NAIT?
NAIT-mom normal platelets, higher risk of hemorrhage
How do you treat NAIT?
If plt <20 in term or <50 in preterm
- Washed maternal platelets
- PLA-1 negative platelet transfusion
How do you treat maternal ITP?
IVIg
What is the definition of polycythemia?
Central Hct >65%
List 3 risk factors for polycythemia
High altitudes Post-dates SGA Recipient infant of TTTS Delayed cord clamping Infants of diabetic mothers Trisomy 13, 18, or 21 Neonatal Graves disease or hypothyroidism Beckwith-Wiedemann syndrome
List 5 severe complications of polycythemia
Seizures Stroke Pulmonary hypertension Necrotizing enterocolitis Renal vein thrombosis Renal failure
When should you consider partial exchange transfusion for polycythemia?
Hct >0.70
OR
Symptomatic and Hct>0.65
What pain management techniques are recommended for minor procedures? (CPS)
Sucrose + non pharmacologic (nonnutritive sucking, kangaroo care, facilitated tuck, swaddling and developmental care)
When should topical anesthetics be used in neonates? (CPS)
Venipuncture
Lumbar puncture
IV insertion
What type of pain medication should be used for post-op analgesia? (CPS)
Opioids
Tylenol as adjunct (>28 weeks)
What pain management for chest drain insertion/removal? (CPS)
Local anesthetic
Fentanyl
What pain management for eye exams? (CPS)
Oral sucrose
Local anesthetic eye drops
List 4 pain management strategies for neonate getting an IV (CPS)
Oral sucrose
Non-nutritive sucking
Swaddling
Topical anesthetic
When should immunizations be given to prems?
According to chronologic age
When should rotavirus be given to prems?
After discharge from NICU
At least 6 weeks of age (less than 15 weeks)
What is fetal PaO2?
25-30
List 4 risk factors for brachial plexus injury
Shoulder dystocia
LGA
IDM
Instrumental delivery
Brachial plexus injury counseling
PBPP is not always preventable.
75% of infants recover completely within the first month of life.
25% experience permanent impairment and disability.
If persistent deficits at 1month old →refer to multi-D brachial plexus team (neurologists and/or physiatrists, rehabilitation therapists and plastic surgeons)
Decisions re: conservative vs. surgical correction and prediction of prognosis based on history, electrodiagnostic procedures, diagnostic imaging and physical examination by the multidisciplinary team. (since no RCTs)
What investigation do you need to do for a patient with suspected Klumpke’s (with Horner’s)?
MRI spine
NCS
Who to screen for ROP and when?
≤ 30+6 wks (regardless of BW) OR
BW of ≤ 1250g
Screen at 31 weeks PMA or 9 weeks CA if GA ≤ 26+6; screen at 4 weeks CA if GA ≥ 27 wks
What is newborn visual acuity?
20/400
Risk factors for NEC in term babies
Birth asphyxia T21 CHD Rotavirus infx Hirschprungs
What is the biggest risk factor for NEC?
Prematurity
When does NEC typically present?
Usually week 2-3 of life, but can be up until 3mo in VLBW
Management of NEC
NPO, NG insertion for decompression, IV fluids
Triple Abx (Amp+gent+flagyl) (after culture drawn)
Monitor resp status and for electrolyte, acid/base balance, DIC
Remove UV/UA if present
Serial AXR to detect perf
List 3 surgical indications for NEC
- Perforation
- Failure of medical management
- Single fixed bowel loop on Xray
List 3 post op complications of NEC
Intestinal strictures
Short bowel syndrome
Cholestatic jaundice (TPN related)
Neurodevelopmental impairment
List 3 ways of preventing NEC
Exclusive breast feeding
Slow increase in feeding volumes in VLBW infants
Probiotics (need more evidence if <1000g)
What % of choanal atresia patients have CHARGE?
10-20%
What is a diagnostic clue to choanal atresia?
Cyanosis worse with feeding
Better with crying
How do you diagnose choanal atresia?
Inability to pass a firm catheter through each nostril 3-4 cm into the nasopharynx
How do you treat choanal atresia?
Feed with McGovern nipple
NG feeds if unilateral until airway established
If bilateral- intubation or tracheotomy may be indicated
Surgical correction
Risk factors for subcutaneous fat necrosis
Preeclampsia
Birth trauma
Prolonged hypothermia
When does subcutaneous fat necrosis first appear?
More likely in first 4weeks in full term/post term infants
What is the natural history of subcutaneous fat necrosis?
Weeks to months
What is one blood test you should check for in subcutaneous fat necrosis?
Calcium
What is the most accurate assessment of GA?
U/S at 8 and 14 weeks’ GA
EFWs tend to underestimate
When should short term tocolysis be used?
To facilitate In-utero transfer to Level 3 and time for ANCS
What is the purpose of MgSO4?
Fetal neuroprotection. Give until 32 weeks
List 4 adverse neurodevelopmental outcomes in preterms
Cerebral palsy
Cognitive impairment (test score ≥ 2SD below mean)
Seizures
Blindness and/or deafness
Behavioural difficulties (e.g. ADHD), language delays, health issues and hospital readmissions
List 5 factors that effect preterm outcome
GA***strongest effect
Birth at a tertiary perinatal centre
ANCS therapy
Female sex
Multiplicity
Can patients with anancephaly donate their organs?
NO
Because of uncetainty surrounding establishment of brain death
CAN donate tissue/stem cells
How do you neonatal seizures typically present?
Transient eye deviations, nystagmus, blinking
Mouthing
Abnormal extremity movements (rowing, swimming, bicycling, pedaling, stepping)
Fluctuations in HR, HTN episodes, and apnea
Clonic, tonic, myoclonic, spasms
List 10 causes of neonatal seziures
HIE ICH Ischemic stroke Intracranial infections (e.g. HSV) Brain malformations Metabolic disturbances (hypoCa, hypoNa, pyridoxine) Drug withdrawal Epilepsy syndromes (benign idioatphic neonatal seizures, benign familial neonatal seizures)
What etiology should you consider in neonate where GTCs began in utero?
Pyridoxine dependent seizures
List 5 poor prognostic signs in HIE
Initial pH <6.7
Apgars of 0-3 at 5 min, low Apgar at 20 min
High base deficit (>20-25 mmol/L)
Decerebrate posture
Lack of spontaneous activity
Absence of spontaneous respirations at 20 min
Persistence of abnormal neurologic signs at 2 weeks of age
• Severe MRI and EEG abnormalities
List 4 risk factors for IVH
Prematurity RDS HIE Hypotension/Hypertension Reperfusion injury of damaged vessels Increased or decreased cerebral blood flow Reduced vascular integrity Increased venous pressure Pneumothorax Thrombocytopenia Hypervolemia
List 3 preventative interventions for IVH
Antenatal steroids
Post-natal prophylactic indomethacin
Delayed cord clamping
Judicious use of operative delivery (minimize traumatic IVH)
What % of IVH is diagnosed within 1st day of life? 3rd day of life?
1st day-50%
3rd day-75%
When does PVL first appear on imaging?
May be present at birth but usually occurs later as an early echodense phase (DOL 3-10), followed by echolucent (cystic) phase (DOL 14-20)
Who should be screened for IVH and when?
<32 weeks GA
1st HUS at DOL 3-7
If initial HUS is normal, when should there be a repeat HUS?
36-40 weeks to evaluate for PVL, because cystic changes related to perinatal injury may not be visible for at least 2-4 weeks
Ddx of neonatal hydrocephalus
Non-communicating
- Syndromic (trisomies 13, 18, 9, and 9p, as well as triploidy )
- Vein of Galen malformation
- Posterior fossa lesions → Chiari, Dandy-Walker, tumours
- X-linked hydrocephalus (mostly aqueductal stenosis)
- Chiari 2
- Tumour
- Arachnoid cyst
- Neurofibromatosis
- Metabolic disease (e.g. Hurlers, achondroplasia)
Communicating
- IVH
- SAH
- Meningitis
- Intrauterine infection
- Choroid plexus papilloma
List 3 alternative diagnoses other than hydrocephalus for large heads
Thickened cranium from chronic anemia, rickets, osteogenesis imperfecta, epiphyseal dysplasia
Chronic subdural collections
Metabolic and degenerative disorders of the CNS
Neurofibromatosis
Familial megalencephaly
List 4 steps in the initial management of CDH
Avoid bag mask ventilation Intubate Insert large bore NG Minimize ventilation pressures: PIP <25 cm Pre-ductal sat >85% Sedation: minimize risk of pneumothorax
How do you calculate GIR?
E.g. Glucose intake for D10W at 60 mL/kg/day
•To calculate in mg/kg/min convert time units
•100 mg/mL x 60 mL/kg/d ÷ 24 h per day ÷ 60 min per
hour
=4.2 mg/kg/min
List 3 reasons for physiologic jaundice
Immaturity of liver enzymes
Increased bilirubin load
(shorter half-life of RBCs,
relative polycythemia)
Increased entero-hepatic
circulation
List 10 differentials for neonatal thrombocytopenia
Unwell
- NEC
- Sepsis
- DIC
- HIE
Dysmorphic
- IUGR
- TORCH
- Trisomy
- TAR
Nondysmorphic
- NAIT
- Maternal ITP
- PIH
- Thrombus
- Viral infection
- Polycythemia
- Vascular (Kasabach Merrit)
Listt 5 causes of anemia in neonates
Anemia of prematurity Parvovirus B19 Diamond Blackfan Hypothyroidism Adrenal insufficiency Hemolysis Abruption Feto-maternal hemorrhage Intracranial hemorrhage TTTS Phlebetomy
List 5 signs of a bleeding disorder in a neonate
Oozing from umbilical stump
Excessive bleeding from PIV/heel stick sites
Large caput succedaneum and cephalohematomas without significant trauma
Prolonged bleeding following circumcision
Intracranial hemorrhage in a late
preterm/term infant
List 5 risk factors for invasive GBS early onset sepsis
- Over 18 h rupture of membranes
- Maternal fever > 38°C
- Premature labour at less than 36 weeks
- GBS bacteriuria at anytime during pregnancy
- Previous child with invasive GBS disease
List 5 features of prune belly syndrome (Eagle Barrett Syndrome)
Cryptoorchidism
Deficiency of abdominal wall musculature
Genitourinary abnormalities
When do you stop ROP screening?
Complete vascularization
Zone III vascularization without previous Zone I or Zone II ROP
PMA of 45 weeks and no pre-threshold disease
Regression of ROP
Discharage criteria for late preterm
Discharge no earlier than 48 hours
Stable vitals: respiratory rate < 60 and heart rate between 100-160
Maintain temperature 36.5 C to 37.4 C in open crib
Demonstrate coordinated suck, swallow, and breathing while feeding
If infant is breast fed, trained health care professionals should observe and document the position, latch and milk transfer
Weight loss should not exceed >10% of birth weight
Absence of medical illness
At least one stool passed spontaneously
List 3 benefits of delayed cord clamping in preterms
Decreased need for transfusions
Lower risk of IVH
Lower risk of NEC
List 3 benefits of delayed cord clamping in term infants
Higher Hgb concentrations in early (but not subsequent assessments)
Improved iron stores
Disadvantage: Higher need for phototherapy for Jaundice
When does erythema toxicum resolve?
5-7 days
How fast should you rewarm in therapeutic hypothermia?
0.5°C every 2 -4 h
If worsening of encephalopathy or seizures occurs, infants may require recooling
List 2 ways of achieving brain hypothermia in HIE
(A) Selective head cooling with mild systemic hypothermia
(B)Total body cooling ***used more frequently
What initial PIP and PEEP should be provided in NRP?
PIP 20-25
PEEP 5 for preterms
List 3 causes of sudden deterioration after intubation of neonate
DOPE D-displaced tube O-Obstructed tube P-PTX E-equipment failure
After how many seconds of chest compressions using 100% O2 should you reassess HR?
60 s
If still <60, give epi
3 ways to keep a preterm warm in a resuscitation
- Room temperature 23-25 degrees Celsius
- Plastic wrap or bag
- Thermal mattress and hat
What does the CPS recommend re: postnatal steroids for BPD?
For patients at high risk of developing CLD, clinicians can consider low dose dex tapered over 7-10 days
DO NOT recommend high dose dex, steroids within first 7 days, low dose dex on assisted ventilation after 7 days
What is appropriate premedication for intubation for neonates (CPS)?
- Vagolytic
- Atropine or glycopyrrolate - Analgesia
- Fentanyl (rapid onset, no effect on respiratory mechanics, short duration of action, good sedation, reliable PK) - Muscle relaxant
- Succinylcholine (rapid onset, short duration of action)
How do you treat chest wall rigidity from fentanyl?
Prevention: give it slowly
Treatment: muscle relaxant or naloxone