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Pharmacology > Respiratory Pahrmacology > Flashcards

Respiratory Pahrmacology Flashcards

1
Q

Albuterol (proventil)

A

Short acting beta 2 agonist that works by relaxing bronchial smooth muscle production broncodilation

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2
Q

Indication for albuterol (proventil)

A

Asthma attacks and bronchospasm

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3
Q

Does albuterol effect b2 of heart

A

Not if dose is smal

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4
Q

MOA albuterol (proventil)

A

Activates b2 receptor in lungs causing relaxation fo bronchial smooth muscle and subsequent bronchodilator

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5
Q

How administer albuterol

A

Inhaled or nebulizer

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6
Q

Side effects albuterol

A

Angina, tachycardia, tremor

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7
Q

Angina and albuterol

A

Inadequate oxygen to the heart

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8
Q

Tachycardia albuterol

A

Can activate b1

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9
Q

Tremor albuterol

A

Yup

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10
Q

Terbutaline (breathine)

A

B2 agonist administered for short term control of asthma and tocolytic to suppress preterm labor

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11
Q

Side effects terbutaline (breathing)

A

Tremors, tachycardia, hypotension, pulmonary edema, hyperglycemia

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12
Q

MOA terbutaline

A

B2 agonist
Increase bronchodilation and reduce resistance of the airway in asthmatics
Also relax SM of uterus and delaying onset of labor

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13
Q

Indications terbutaline

A

Asthma

Tocolytic -delays preterm labor by relaxing AM of uterus and stopping contraction

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14
Q

Tachycardia and terbutaline

A

Can stimulate b1 at high doses -increase heart rate, angina, palpitations, cardiac ischemia
Chest pain, nervousness, somnolence, flushing

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15
Q

Tremor terbutaline

A

Overstimulation b2 b1 at high dose

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16
Q

Hypotension terbutaline

A

High dose b1 hr increase causing decrease in bp and fluid volumes shift compartments, changes in electrolytes can occur resulting in hypothalamic

17
Q

Pulmonary edema terbutaline

A

Stimulate b1 could possibly increase the leaking of fluid from capillaries thus promoting the development of pulmonary edema

18
Q

Hyperglycemia terbutaline

A

Overactivation of b2

Careful in diabetics

19
Q

Theophylline

A

Methylxanthine medication used to treat asthma (and sometimes COPD). Metabolized by p450 and works by inhibiting phosphodiesterase, leading to increased cAMP, which causes bronchodilation.

20
Q

MOA theophylline

A

Inhibits phosphodiesterase (which breaks down cAMP to AMP) increased cAMP lead to bronchodilation
Also inhibits TNFa , leukotrienes, and inhalation
Increases cAMP

21
Q

Indications for theophylline

A

Asthma also COPD and infant apnea

22
Q

Side effects theophylline

A

Cardiotoxicity, neurotoxicity, blocks adenosine action (blocks A1, 2, 3 adenosine receptors in the heart. May cause arrhythmias to occur in patients who were taking adenosine previously)

23
Q

Chromodynamics (mast cell stabilizers)

A

Chromodynamics sodium (intel) or cromoglicic acid is a medication prevents the release of inflammatory agents like histamine from entering the tissue.

24
Q

MOA cromolyn

A

Stabilizes mast cels, which break down as part of inflammatory reaction to release histamine (vasodilator) prevent mast cells from breaking down and releasing contents

25
Q

Indication cromolyn

A

Asthma prophylaxis
Bronchial inflammation
Allergic rhinitis

26
Q

Side effects cromolyn

A

Cough (increases the viscosity of mucus secretions), bronchospasm

27
Q

How is cromolyn given

A

Fixed schedule

28
Q

Montelukast (singular)

A

Leukotrienes modifier that works by blocking the action of leukotrienes receptors int he lungs and bronchial tubes, reducing inflammation and bronchoconstriction in patients with asthma

29
Q

Indication for montelukast

A

Allergic rhinitis, exercise induced bronchospasm prention or maintence therapy of asthma

30
Q

Why shouldn’t montelukast be used to treat asthma attacks

A

Not fast acting

31
Q

Side effects of montelukast

A

Fatigue, headache, suicidal thoughts, changes in mood, increased risk of developing churg-Strauss syndrome (eosinophilia granulomatosis with polyangitis)

32
Q

MOA montelukast

A

Leukotrienes are inflammatory mediators, responsible for producing bronchoconstriction, inflammation, and airway edema in patients with asthma.

Montelukast blocks the action of leukotriene receptors in the lungs and bronchial tubes, thereby reducing inflammation and bronchoconstriction

33
Q

Indications for montelukast

A

Allergic rhinitis, asthma prophylaxis, exercise induced bronchospasm

34
Q

Allergic rhinitis and singular

A

For patients who do not respond to intranasal glucocorticoid or antihistamine therapy, due to rare but serious side effects that can occur

35
Q

Side effects montelukast (Singulair)

A

Fatigue, headache, mood changes, suicidal thoughts

36
Q

Montelukast (singulair) and churg-Strauss

A
  • an eosinophilia granulomatosis with polyangitis
  • life threatening autoimmune disorder that causes inflammation of the blood vessels. Can lead to tissue death and destruction of the lungs
37
Q

What is a common sign of churg Strauss

A

Asthma

Pharmacology (52 decks)

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