Neuropharm CNS Stimulants

Question 1

CNS stimulants

Answer 1

For ADHD and weight loss

Question 2

Types of CNS stimulants

Answer 2

Methylphenidate, dextroamphetamine, and methamphetamine

Question 3

Mechanism of cns stimulants

Answer 3

Increase catecholamine, such as NE and dopamine availability at the synaptic cleft
Inhibiting reputable of NE and dopamine, further increasing their bioavailability

Question 4

Methylphenidate

Answer 4

ADHD

Question 5

Methamphetamine

Answer 5

Weight loss

Question 6

Side effects cnS stimulants

Answer 6

Abuse and addicitivity

Question 7

MOA CNS stimulants

Answer 7

Increase catecholamine at synaptic cleft via direct release from stored vesicles leading to increased NE and dopamine bioavailability is by inhibiting their reputable

Question 8

Methylphenidate (Ritalin)

Answer 8

ADHD and ADD

Off labels uses include obesity, lethargy and depression

Question 9

Methtamphetamine

Answer 9

Controlled CNS stimulant for obesity

Off label are narcolepsy and depression

Question 10

CNS stimulants potential for abuse

Answer 10

These drugs are often abused for recreational use and can be highly addictive

Question 11

CNS stimulant indications

Answer 11

ADHA obesity and narcolepsy

Question 12

___ are CNS stimulants that promote NT release and enhance neuronal excitation.

Answer 12

Amphetamines

Question 13

MOA CNS stimulants

Answer 13

Bind to adrenergic receptors that normally attach to NT, such as NE, E, and Dopamine

Question 14

Why wouldn’t one recommend CNS stimulant for weight loss

Answer 14

Abuse and addiction

Question 15

Amphetamine

Answer 15

Controlled CNS stimulant for ADHD and obesity

Off label narcolepsy and depression

Question 16

Methylphenidate (Ritalin)

Answer 16

ADHA ADD obesity

Question 17

CNS stimulant and narcolepstt

Answer 17

Amphetamine activate the CNS and cause feeling of wakefulness and alertness to counteract tiredness

Question 18

CNS stimulants and obesity

Answer 18

Weight loss bc reduce appetite

Question 19

CNS stimulants and ADHS, “drug holidays”

Answer 19

Don’t take on weekends bc concern with growth as kids

Let them grow

Question 20

What do CNS stimulant bind to

Answer 20

Adrenergic receptors that normally attach to NT NE, E, D.

Question 21

Side effects of CNS stimulants

Answer 21

Euphoria, talkativeness, insomnia, hypertension, tachycardia, psychosis, anorexia

Question 22

Why CNS stimulant and hypertension

Answer 22

Mimic effects of NE in the blood vessels and cause excessive vasoconstriction that may develop hypertension

Question 23

CNS stimulant and tachycardia and dysrhythmias

Answer 23

Mimic NE, increase HR, Av conduction and force contraction

Question 24

Psychosis and CNS stimulants

Answer 24

Schizophrenic symptoms

Question 25

CNS stimulants and anorexia

Answer 25

Loss of appetite

Question 26

CNS stimulants and tolerance

Answer 26

Develops with chronic use as body adopts to the effects of CNS stimulants, the patient may increase the dosage and frequency to yield desired euphoric effect

Question 27

CNS stimulants and abuse/dependence

Answer 27

Euphoria -risk of abuse

Abstinence syndrome if abruptly stop

Question 28

Abstinence syndrome

Answer 28

Exhaustion, depression, excessive sleeping and eating, and craving the drug

Question 29

Bupropion

Answer 29

Atypical antidepressant for smoking cessation

Question 30

Side effects of bupropion

Answer 30

Insomnia, tachycardia, seizure , stimulant side effects

Question 31

Indications for amphetamine s

Answer 31

Narcolepsy, hyperactivity in kids, obesity

Question 32

Feelings associated with amphetamine

Answer 32

Euphoria, paranoia, anxiety

Question 33

Side effects amphetamines

Answer 33

Mydriasis, hypertension, tachycardia

Excessiveuse may cause insomnia, hypertension, enorexia, and seizures

Question 34

Compared with abuse of other substances, amphetamines are more likely to induce feelings of ___ and ___

Answer 34

Anxiety and paranoia

Question 35

Amphetamine and euphoria

Answer 35

Increased energy and sharpened mental alertness

Increased mental agility and muscular power

Question 36

What methods of administrationsof amphetamine slower onset of euphoria? What causes quick euphoria

Answer 36

Snorting oral

Smoking IV

Question 37

Mydriasis and amphetamine

Answer 37

Prevent reputable of NE

Increased levels of Ne bind adrenergic receptors and causes pupillary dilation or mydriasis

Question 38

Amphetamine overdose causing seizure may be treated with what

Answer 38

Benzodiazepines, such as lorazepam

Question 39

How treat amphetamine toxicity

Answer 39

Ammonium chloride which acidified the urine and traps the amphetamine, which is slightly basic int he urine to be excreted from the body

Question 40

Ammonium chloride

Answer 40

Causes acidification of urine which keeps weakly basic amphetamines in a charged state preventing them from being reabsorbed into the body

Question 41

Ammonium chloride causes _ of the urine which keeps weakly basic amphetamines in a charged state preventing them from being reabsorbed into the body

Answer 41

Acidification

Question 42

Cocaine

Answer 42

Potent central nervous system stimulant that stimulates behavioral and psychomotor agitation.

Question 43

Symptoms of cocaine abuse

Answer 43

Euphoria, delusions, mydriasis, hallucinations, agitation , hypertension, cardiac arrhythmias, and hyperthermia which may result in seizure activity. Nasal septum perforation

Question 44

Cocain and mydriasis

Answer 44

Overstimulat the sympathetic and parasympathetic nervous system and activate the muscles to initiate the fight or flight response

Question 45

Cocaine seizures and increase in bp cause what

Answer 45

Seizures

MI, intracranial hemorrhage