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Pharmacology > Neuropharm CNS Stimulants > Flashcards

Neuropharm CNS Stimulants Flashcards

1
Q

CNS stimulants

A

For ADHD and weight loss

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2
Q

Types of CNS stimulants

A

Methylphenidate, dextroamphetamine, and methamphetamine

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3
Q

Mechanism of cns stimulants

A

Increase catecholamine, such as NE and dopamine availability at the synaptic cleft
Inhibiting reputable of NE and dopamine, further increasing their bioavailability

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4
Q

Methylphenidate

A

ADHD

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5
Q

Methamphetamine

A

Weight loss

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6
Q

Side effects cnS stimulants

A

Abuse and addicitivity

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7
Q

MOA CNS stimulants

A

Increase catecholamine at synaptic cleft via direct release from stored vesicles leading to increased NE and dopamine bioavailability is by inhibiting their reputable

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8
Q

Methylphenidate (Ritalin)

A

ADHD and ADD

Off labels uses include obesity, lethargy and depression

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9
Q

Methtamphetamine

A

Controlled CNS stimulant for obesity

Off label are narcolepsy and depression

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10
Q

CNS stimulants potential for abuse

A

These drugs are often abused for recreational use and can be highly addictive

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11
Q

CNS stimulant indications

A

ADHA obesity and narcolepsy

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12
Q

___ are CNS stimulants that promote NT release and enhance neuronal excitation.

A

Amphetamines

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13
Q

MOA CNS stimulants

A

Bind to adrenergic receptors that normally attach to NT, such as NE, E, and Dopamine

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14
Q

Why wouldn’t one recommend CNS stimulant for weight loss

A

Abuse and addiction

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15
Q

Amphetamine

A

Controlled CNS stimulant for ADHD and obesity

Off label narcolepsy and depression

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16
Q

Methylphenidate (Ritalin)

A

ADHA ADD obesity

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17
Q

CNS stimulant and narcolepstt

A

Amphetamine activate the CNS and cause feeling of wakefulness and alertness to counteract tiredness

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18
Q

CNS stimulants and obesity

A

Weight loss bc reduce appetite

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19
Q

CNS stimulants and ADHS, “drug holidays”

A

Don’t take on weekends bc concern with growth as kids

Let them grow

20
Q

What do CNS stimulant bind to

A

Adrenergic receptors that normally attach to NT NE, E, D.

21
Q

Side effects of CNS stimulants

A

Euphoria, talkativeness, insomnia, hypertension, tachycardia, psychosis, anorexia

22
Q

Why CNS stimulant and hypertension

A

Mimic effects of NE in the blood vessels and cause excessive vasoconstriction that may develop hypertension

23
Q

CNS stimulant and tachycardia and dysrhythmias

A

Mimic NE, increase HR, Av conduction and force contraction

24
Q

Psychosis and CNS stimulants

A

Schizophrenic symptoms

25
Q

CNS stimulants and anorexia

A

Loss of appetite

26
Q

CNS stimulants and tolerance

A

Develops with chronic use as body adopts to the effects of CNS stimulants, the patient may increase the dosage and frequency to yield desired euphoric effect

27
Q

CNS stimulants and abuse/dependence

A

Euphoria -risk of abuse

Abstinence syndrome if abruptly stop

28
Q

Abstinence syndrome

A

Exhaustion, depression, excessive sleeping and eating, and craving the drug

29
Q

Bupropion

A

Atypical antidepressant for smoking cessation

30
Q

Side effects of bupropion

A

Insomnia, tachycardia, seizure , stimulant side effects

31
Q

Indications for amphetamine s

A

Narcolepsy, hyperactivity in kids, obesity

32
Q

Feelings associated with amphetamine

A

Euphoria, paranoia, anxiety

33
Q

Side effects amphetamines

A

Mydriasis, hypertension, tachycardia

Excessiveuse may cause insomnia, hypertension, enorexia, and seizures

34
Q

Compared with abuse of other substances, amphetamines are more likely to induce feelings of ___ and ___

A

Anxiety and paranoia

35
Q

Amphetamine and euphoria

A

Increased energy and sharpened mental alertness

Increased mental agility and muscular power

36
Q

What methods of administrationsof amphetamine slower onset of euphoria? What causes quick euphoria

A

Snorting oral

Smoking IV

37
Q

Mydriasis and amphetamine

A

Prevent reputable of NE

Increased levels of Ne bind adrenergic receptors and causes pupillary dilation or mydriasis

38
Q

Amphetamine overdose causing seizure may be treated with what

A

Benzodiazepines, such as lorazepam

39
Q

How treat amphetamine toxicity

A

Ammonium chloride which acidified the urine and traps the amphetamine, which is slightly basic int he urine to be excreted from the body

40
Q

Ammonium chloride

A

Causes acidification of urine which keeps weakly basic amphetamines in a charged state preventing them from being reabsorbed into the body

41
Q

Ammonium chloride causes _ of the urine which keeps weakly basic amphetamines in a charged state preventing them from being reabsorbed into the body

A

Acidification

42
Q

Cocaine

A

Potent central nervous system stimulant that stimulates behavioral and psychomotor agitation.

43
Q

Symptoms of cocaine abuse

A

Euphoria, delusions, mydriasis, hallucinations, agitation , hypertension, cardiac arrhythmias, and hyperthermia which may result in seizure activity. Nasal septum perforation

44
Q

Cocain and mydriasis

A

Overstimulat the sympathetic and parasympathetic nervous system and activate the muscles to initiate the fight or flight response

45
Q

Cocaine seizures and increase in bp cause what

A

Seizures

MI, intracranial hemorrhage

Pharmacology (52 decks)

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