Integumentary Pharmacology Flashcards
Silver sulfadiazine (silvadene) and mafenide acetate (sulfamylon)
Sulfonamides that disrupt the synthesis of folic acid necessary for DNA, RNA and protein synthesis. This action makes sulfonamides broad spectrium antimicrobials
Indication for silver sulfadiazine (silvadene) and mafenide acetate (sulfamylon)
Burns and open wound care
Side effects silver sulfadiazine (silvadene) and nafenide acetate (sulfamylon)
Pain and acidosis.
Prior to performing wound care, __ should be administered to decrease pain
Analgesics
MOA silver sulfadiazine and mafenide acetate
Topical antimicrobial
Decreases bacteria such as pseudomonas aeruginosa
Silver sulfadiazine
Releases free silver to suppress bacterial colonization and decrease antimicrobial counts
Mafenide acetate
Acts as a sulfonamide and disrupts bacterial DNA synthesis by interrupting folic acid synthesis
Since mammalian cells use preformed folic acid obtained by diet, the drug does not harm mammalian DNA and protein synthesis
Ok
Indication for silver sulfadiazine and mafenide acetate
Burns open wound care
Burns silver sulf and mafenide acetate
Decrease bacterial colonization in patients with second and third degree burns
Help prevent the progression of second degree wounds into third degree
Silver sulf burns
Softens Escher and helps with the removal of dead tissue fo grafting
Side effects silver s and mafenide a
Ss no significant side effects
Mafenide-serious side effects
What open would can we use ss and ma on
Herpes blisters, burns
Mafenide side effects
Pain and acidosis (metabolized into a chemical that decreases the kidneys ability to excrete acids)
Why give analgesic prior to wound care with mafenide
Causes pain
