Respiratory Medicine Flashcards
How can the mast cells be stimulated if not directly from allergen?
Allergen stimulates cd4 lymphocyte ( th2 cells)
Interleukin 4 produced
Be cells stimulated to produce igE
Mast cells stimulated
What are symptoms of asthma?
Wheeze
Breathlessness
Cough
How is asthma assessed?
Peak flow readings- plotted by sex, age and heigh
What can be precipitants of asthma?
Allergens Irritants Exertion NSAIDs Emotion
What medications are used to treat asthma?
Inhaled b2 agonists
Inhaled steroids
Combination inhalers
Anti leukotrienes
What b2 antagonist is short acting?
Salbutamol
What b2 agonist is long acting ?
Salmeterol
What is an inhaled steroid?
Beclamethasone
What is a combination inhaler?
Seri tide
What is an anti leukotrienes?
Montelukast
How is moderate asthma defined?
Peak flow 50-75%
No features of acute
Resp and pulse rate normal
What defines acute severe asthma?
Peak flow 33-50%
Resp rate >25
Heart rate > 110
Inability to complete sentences in one breath
What defines unstable asthma?
Recent infections
Poor compliance
Symptoms- requiring more frequent inhaler or reduce exercise limit
Change of meds by gp
Dental aspects re. Asthma
Avoid NSAIDs
Oral candidiasis
Altered taste
Dry mouth
What IS COPD?
Airflow obstruction that is not fully reversible
Progressive
Often caused by smoking
What is FEV.?
Forced expired volume in 1 second
What is FVC
Vital capacity
What defines obstruction?
FEV/FVC = less than 0.7
What is the pathophysiology of COPD?
Emphysema- alveolar destruction
Bronchitis- airway inflammation, increased mucous
What are symptoms of COPD?
Breathlessness pop exertion
Wheeze- consistent
Chronic cough and sputum
Frequent infections due to stagnant mucous
What are pulmonary lung function test
Lung function
Spirometry
FEV1
FVC