π§πΎ- Respiratory & Hematology Test Flashcards
WBC (leukocytes)
Regulated by tissue damage
Normal range 4.5 - 13.5
Fights infection
WBC differential count
- neutrophils (54-62%) (bacteria)
- bands (immature neutrophils) (3-5%) leukemia
- eosinophils (1-3%) (allergies, parasites, cancers)
- basophils (0-0.1%) (healing tissues)
- lymphocytes (25-33%) (chronic inflammation)
- monocytes (3-7%) (early inflammation)
Shift to the left
More bands (immature or baby neutrophils, donβt fight infection) in circulation than there are segs (mature or grownup neutrophils)
Platelets
Function: clot formation
Normal range: 150-400
Life span 8-10 days
Who is most at risk for Fe deficiency anemia
Cause- inadequate Fe in diet
At risk-
Premature due to maternal Fe stores depleted to quickly
12-36 month olds due to whole milk intake with zero sources of Fe
Adolescents due to inadequate diet, growth spurts, menses
Infant feeding and Fe
Breast fed- Fe supplements by FOUR months
Premature - Fe supplements by TWO months of age
**give Fe on an acid stomach /between feedings or with vitamin C **
What should you educate the family on with Fe deficiency anemia and supplements
- Fe will turn stools greenish black color
- can stain teeth (use straw, brush after)
- milk babies are overweight due to increased whole milk consumption thatβs a poor source of Fe and causes increased fecal blood loss
What is the patho of Sickle cell anemia
AUTOSOMAL RECESSIVE DISORDER
- normal HgA is replaced with HgS
- sickling occurs with low O2
- sickled RBC are fragile and rapidly destroy
anemia results when rate of destruction is greater than production
What does autosomal recessive mean
Meaning 2 copies of an abnormal gene must be present from mom and dad to develop disease
Causes of sickling RBCs
Low O2
Dehydration
Strenuous exercise, infections, fever, anemia, high altitudes, underwater swimming, non-pressurized flights, stress, anesthesia
Vaso-occlusive crisis /hand foot syndrome
Obstruction of blood vessels and causes distal ischemia
Most common in small vessels but can occur ANYWHERE in the body
Presents as hand foot syndrome and is most common in 6months -2yrs
Sickle crisis occurs in what parts of the body
Chest - acute chest syndrome
Heart - heart attack
Brain - stroke
Liver - jaundice
Kidney - failure
Eyes - blindness
Abdomen - obstruction
Penis - priapism
Symptoms of a sickle crisis
Pain in abd, legs , arms, hands , etc
Swelling of joints
Fever
Pallor
Weakness
Jaundice
Enlarged spleen
Diagnostic evaluation of sickle cell
Sickle - turbidity (sickledex): simple blood test that doesnβt differentiate between trait or disease
HgB electrophoresis: differentiates between trait and disease , βfinger printingβ of protein
Care of a sickle cell client
Prevent sickling
Promote adequate O2
Maintain hemodilution
Penicillin phrophaxis by 2 months old
Meningococcal vaccine (MCV4)
What is to be expected to be seen in clients with sickle cell
Growth delays, delayed sexual maturation and very susceptible to sepsis
Treatment of sickle cell crisis
- bedrest
- hydration (100-125ml/kg/DAY)
- opioid analgesics (morphine)
- NSAIDS (ibuprofen and ketorolac)
- electrolyte replacement
- HEAT APPLICATION ! NO ICE = SLOWS CIRCULATION
- antibiotics
- daily folic acid
- hydroxyurea
- blood transfusions
- allogenic hematopoietic stem cell transplant
Cause of death with sickle cell
Infections causing severe sickling
Patho of beta thalassemia (Cooley anemia)
AUTOSOMAL RECESSIVE DISORDER
- disease causes deficiency in synthesis of beta chains
- leads to destruction of RBCβs
This destruction causes anemia
Diagnosis of beta thalassemia
- hemoglobin electrophoresis
- increased RBC with decreased HgB & Hct
Signs and symptoms of beta thalassemia
Mediterranean decent , anemia , fever , poor feeding , enlarged spleen AND liver , headache , bone pain , exercise intolerance , delayed growth and sexual maturation
Treatment of beta thalassemia
Blood transfusions (goal to keep HgB above 9.5 g/dl)
Treat for Fe overload (chelating therapy)
Stem cell transplant
Hemosiderosis
Fe overload
Nursing care for beta thalassemia
Administer blood
Death is caused by heart failure related to severe anemia