Respiratory - Exam 4 Flashcards
Anticholinergics inhibit what type of nerve impulse?
parasympathetic
Anticholinergics work by ?
selectively blocking the binding of the neurotransmitter acetylcholine (ACH)
pneumonic for effects of anticholinergics?
hot as a car (increased body temp), blind as a bat (Mydriasis - dilated pupils), dry as a bone (dry eyes, mouth, decreased sweat), red as a beet (flushed face), mad as a hatter (delirium)
anticholinergics are divided into three categories in accordance with their ?
specific targets in the central and/or peripheral nervous system
anticholinergic three catergoies
antimuscarinic ACH agents ganglionic blockers (pre and post ganglionic of ANS) neuromuscular blockers ( cause paralysis)
Anticholinergics cause and inhibit what
bronchodilation and inhibit nasal secretions
prevent acute bronchospasm in bronchitis, emphysema, rhinorrhea and COPD
Common inhaled Anticholinergics?
Ipratropium (Atrovent)
Tiotropium (Spiriva)
Ipratropium and albuterol combination ( Combivent)
what Anticholinergic do you have to watch for potential additive Anticholinergic effects
?
Tiotropium (Spiriva)
Ipratropium (Atrovent) dosage for COPD maintenance and an asthma exacerbation )mod-severe)
COPD - 2 puffs inhaled lid
asthma - 8 puffs inhaled q20 min prn
Combivent subclass?
Anticholinergics, Inhaled; Beta-2 Agonists : short acting inhaled
Three main respiratory disorders that are responsive to treatment?
allergic rhinitis
Asthma
Cough
Two main respiratory disorders that are less responsive to treatment?
COPD
Chronic bronchitis
Bronchodilators beta receptors
class of sympathomimetic agents which act upon the beta adrenoceptors
Beta adrenoreceptor agonist mimic the action of ?
epi and norepinephrine
Activation of _____ receptors induces ______ _________ )force of contraction of the heart), ____________ ______ (rate) of the cardiac mucle - leading to increased heart rate and blood pressure
Beta 1
Inotropic
Chronotropic output
secretion of _______ from the stomach (hunger hormone) - drives hunger response
ghrelin
_____ released from the kidneys (renal perfusion, increased BP)
Renin
Activation of _____ receptors causes ______ muscle relaxation in _____ __ and blood vessels and it also _________ heart rate and heart ______ ___________
Beta 2
smooth
lungs, GI
increased heart rate and heart muscle contraction
where are beta 3 receptors mainly located ? when they are activated what does it induce?
adipose tissue
it induces metabolism of lipids
what are bronchodilators also know as?
beta-2 receptor agonists or beta agonists
where are bronchodilators used?
they are used to treat the reversible bronchoconstriction seen in asthma
bronchodilators stimulate both _____ & _____ adrenergic receptors
beta 1 and beta 2
beta 2 stimulates can induce ______________ if given parenterally like inhaled or injection
adverse effects
tachycardia and palpitations
Some adverse effects of beta 2 agonists
tremor tachycardia sweats agitation severe: pulmonary edema, myocardial ischemia and cardiac arrhythmia