Respiratory: COPD Flashcards
1
Q
Where do M1 receptors act?
A
At the ganglia- the facilitate transmission mediated by ACh on nicotinic receptors
2
Q
Where do the M2 act?
A
Post ganglionic- reduce ACh production
3
Q
Where do M3 act?
A
Smooth muscle- mediate contraction to ACh
4
Q
What does activation of M3 receptors cause
A
coupling with Gq receptors activates phospholipase C which increases Calcium induced calcium release from SR and causes contraction
5
Q
Name two SAMAs
A
Ipratropium
Oxitropium
6
Q
Name two LAMAs
A
Tiotropium
Aclidinium
7
Q
Which one is non selective?
A
Ipratropium
8
Q
Whihc receptro do you not want to block
A
M2
9
Q
Name an ultra LAB
A
indacaterol
10
Q
What other drug can be used to control COPD?
A
Phosphodiesterase 4 inhibitors
11
Q
Name a PDE4 inhibitor
A
Rofumilast
