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Pharmacology > Principles > Flashcards

Principles Flashcards

1
Q

Is ejaculation regulated by parasympathetic or sympathetic nerves?

A

Sympathetic

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2
Q

Is erection regulated by parasympathetic or sympathetic nerves?

A

Parasympathetic

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3
Q

What is contained in the receptor of a G protein coupled receptor?

A

It is an integral membrane protein.

Single polypeptide with NH2 and COOH

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4
Q

What is contained in a g protein?

A

peripheral membrane protein
consists of three polypeptide subunits (alpha, beta, gamma)
contains a guanine nucleotide binding site

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5
Q

What binds to the G protein alpha subunit when there is no signalling?

A

GDP

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6
Q

What happens to g proteins when a signal is turned on?

A

GDP dissociates and GTP binds to the alpha subunit
G protein dissociates into alpha and betagamma subunits
alpha combines with effector

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7
Q

How is a signal turned off?

A

GTPase hydrolyses GTp to GDP and inorganic phosphate

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8
Q

What do nicotinic acetycholine receptors consist of?

A

five glycoprotein subunits

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9
Q

What is the name of the enzyme that degrades acetylcholine?

A

AChE

Acetylecholinesterase

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10
Q

Which drug blocks ganglionic transmission?

A

Hexamethonium

blocks the channels by open channel block

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11
Q

What controls the reuptake of NA

A

U1 and U2 transporters

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12
Q

WHat is MAO

A

monoamine oxidase- metabolises noradrenaline

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13
Q

What to enzymes metabolise noradrenaline?

A

MAO and COMT (catechol -o- methyltransferase)

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14
Q

What are the effects of cocaine on U1?

A

Blocks U1- NA accumulates in synaptic cleft- increased adrenoceptor stimulation

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15
Q

What effects does cocaine cause?

A

Vasoconstriction and cardiac arrhythmias

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16
Q

What does amphetamine do?

A

Taken up into celss by U1- inhibits MAO- noradrenalin not metabolised and displaces into the cytoplasme- accumulates in the synaptic cleft. same perifpheral action as cocaine

17
Q

What is prazosin?

A

Selective, competitive alpha 1 antagonist. Anti hypertensive.

18
Q

What is atenolol?

A

Selective, competitive antagonist of beta 1. Anti anginal and anti hypertensive

19
Q

What is salbutamol?

A

Selective agonist of beta 2. Bronchodilator

20
Q

What is atropine?

A

Competitive antagonist of all muscarinic receptors. Used to reverse bradycardia following an MI and in anticholinesterase poisoning

Pharmacology (13 decks)

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