Respiratory articles Flashcards

1
Q

Postoperative regurgitation and respiratory complications in brachycephalic dogs undergoing airway surgery before and after implementation of a standardized perianesthetic protocol

Renata S. Costa et al, javma 2020

A

Protocol:

  • pre-op famotidine 1 mg/kg and reglan 0.5 mg/kg
  • avoid peri-op opioids, admin 0.15 mg/kg IV dexSP before airway sx
  • post-op recovery in ICU, delay extubation until fully alert, nasotracheal/HFNC to aid recovery, sedation PRN, monitor temp/c+/nasal d/c

Implementation reduced post-op regurgitation (35–>9%)

Hx of R+ pre-op was associated w/ development of post-op R+

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2
Q

Anesthetic risk during subsequent anesthetic events in brachycephalic dogs that have undergone corrective airway surgery: 45 cases (2007–2019)

Crystal R. Doyle, et al javma 2020

A

Having BOAS sx decreased post-ax complication by 79%

Intraop bradycardia increased risk of post-op complication

Every 15 minute increased in ax time increased odds of having intra-oax complication and post-ax complication

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3
Q

Effect of ultraviolet germicidal irradiation of the air on the incidence of upper respiratory tract infections in kittens in a nursery

Robyn A. Jaynes, et al javma 2020

A

UV irradiation - 1 within heating/ventilation/AC system and 1 within ceiling

Incidence of URI decreased by 87.1%

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4
Q

Short-, intermediate-, and long-term results for endoluminal stent placement in dogs with tracheal collapse

Chick Weisse et al javma 2019

A

93% survived to discharge, MST almost 3 years

Majority had improved goose-honking and dyspnea
Younger male dogs had longer MST

Mainstem bronchi collapse didn’t affect MST

Tracheal infection/pneumonia, stent fx and tissue ingrowth are most common complications

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5
Q

Long-term outcome and risk factors associated with death or the need for revision surgery in dogs with permanent tracheostomies

Janet A. Grimes et al javma 2019

A
  1. 35% revised; brachy more likely
  2. 61% had major complications: aspiration pneumonia, skinfold occlusion, stoma stenosis
  3. MST shorter if received steroids before trach, had tracheal collapse or older

usually for LC or LarPar

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6
Q

Lung ultrasonography findings in dogs with various underlying causes of cough

Jessica L. Ward et al javma 2019

A
  1. Bacterial pneumonia -> subpleural shred signs
  2. Neoplasia -> subpleural nodule signs
  3. Dogs with CPE had higher total B-line scores and higher numbers of LUS sites strongly positive for B lines (> 3 B lines/site) than other dogs
    - B lines >10 and >2 sites strongly +ve for B-lines was 92% Sn and 94% Sp for cardiogenic PE
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7
Q

Distribution of alveolar-interstitial syndrome in dogs and cats with respiratory distress as assessed by lung ultrasound versus thoracic radiographs

Jessica L. Ward et al jvecc 2018

A

LUS and TXR were both useful
-LUS more useful in cranial and TXR more useful in caudal quadrant

LUS detected high incidence of AIS compared to TXR

CPE = diffuse AIS
Pneumonia = Unilateral 
Airway/neuro = absence of AIS in all quadrants
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8
Q

Risk factors, characteristics, and outcomes of acute respiratory distress syndrome in dogs and cats: 54 cases.

Ludivine Boiron, et al jvecc 2019

A
Dogs= more pulmonary causes, main risk factor pneumonia
Cats= mixed direct/indirect causes, main risk SIRS 

49% vented

Mortality: 84% in dogs 100% in cats

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9
Q

Comparison of high flow nasal cannula oxygen administration to traditional nasal cannula oxygen therapy in healthy dogs.

Tiffany A Jagodich, et al jvecc 2019

A

CPAP achieved at 1-2 L/kg/min (recommended)
FiO2 at all HF rate > 1L/kg/min achieved 95%
Complication =aerophagia

**Nasal cannula at 100 ml/kg/min only achieve FiO2 0.27 (SACCM reports 0.37) –> need at least 100+ ml/kg/min

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10
Q

Evaluation of pulse oximetry as a surrogate for PaO2 in awake dogs breathing room air and anesthetized dogs on mechanical ventilation.

Kate S Farrell, et al jvecc 2019

A

SpO2 is not a surrogate for PaO2 though better with ventilated patient

Cutoff of PaO2 <80 mmHg for hypoxemia correlated to SpO2 of 95% with 77% sp and 89.5 Sn
–7% of the time SpO2 can’t detect hypoxemia and false +Ve for SpO2

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11
Q

Continuous positive airway pressure (CPAP) provision with a pediatric helmet for treatment of hypoxemic acute respiratory failure in dogs

Gianila Ceccherini, et al jvecc 2020

A

Able to deliver CPAP for those w/ hypoxemic resp failure

PaO2, A-a gradient, PF ratio, %SO2 improved 1h post helmet

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12
Q

Development of a tension pneumomediastinum during mechanical ventilation of a young Irish Wolfhound

Kristin M. Zersen et al jvecc 2020

A

In people 2dry pneumomediastinum most commonly caused by blunt force trauma or MV

Progressive CVS collapse despite -ve pressure obtained through chest tube

Suspect 2ry to overdistension + alveoli rupture –> dissection of air into perivascular space and tracking of air to the pulmonary hilum and mediastinum (Mackin effect)

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13
Q

High-flow nasal cannula oxygen therapy in acute hypoxemic respiratory failure in 22 dogs requiring oxygen support escalation

Tiffany A. Jagodich et al jvecc 2020

A

High flow decreased RR at 1h and dyspnea score, and increased SpO2.

60% of dogs responded to HFNC by 30 mins. 45% of responder survived.

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14
Q

Successful tracheoscopy-assisted reconstruction of traumatic tracheal avulsion in a cat

Michelle R. Joffe et al jvecc 2020

A

Intrathaoracic tracheal avulsion after HBC –> tracheoscopic assisted tracheal anastomosis –> did well

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15
Q

Preliminary evaluation of the use of high-flow nasal cannula oxygen therapy during recovery from general anesthesia in dogs with obstructive upper airway breathing

Tiffany A. Jagodich, et al jvecc 2020

A

HFNC reduced dyspnea score and stertor post-ax –> IMPROVED AIRFLOW

Can cause aerophagia and hypercapnia

Hypercapnia? Increased sedation/opioid OR increased resistance to exhalation during high gas flow.
Usually normocapnia maintained in BAS dog from improved airflow + nasopharyngeal washout by HF

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16
Q

Evaluation of the effects of helmet continuous positive airway pressure on laryngeal size in dogs anesthetized with propofol and fentanyl using computed tomography

Vincenzo Rondelli DVM et al jvecc 2020

A

CPAP 5 cmH2O

Laryngeal volume and cross-sectional area increased during CPAP

Helmet CPAP may be helpful to maintain upper airway patency in non-intubated dogs

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17
Q

Seizure activity following atracurium continuous rate infusion in three mechanically ventilated juvenile dogs

Rebekah E Donaldson et al jvecc 2020

A

2-3 months old
Post-atracurium CRI for vent had seizures in first 24h post extubation

atracurium degraded into laudanosine which has been associated w/ CNS excitement + sz in people – maybe this is what caused it

18
Q

Quality of life following mechanical ventilation in dogs and cats

Rebekah E. Donaldson, et al jvecc 2020

A

Minimal change to QoL, more likely in those vented for neuro reasons

All pet owners said would vent again

19
Q

Immediate, short-, and long-term changes in tracheal stent diameter, length, and positioning after placement in dogs with tracheal collapse syndrome

Matthew Raske, jvim 2018

A

Intraluminal tracheal stenting associated w/ minimal, acceptable and predictable stent shortening and no clinically relevant migration

Malformed tracheas have less stent shortening - maybe d/t abnormal cartilage rings limiting expansion

20
Q

Clinical features of canine pulmonary veno-occlusive disease and pulmonary capillary hemangiomatosis.

Carol R Reinero, et al jvim 2019

A

Acute onset resp distress

TXR: enlarged pulmonary arteries, right cardiomegaly and patchy or diffuse interstitial to alveolar patterns

MST 3 days

21
Q

Recurrent bacterial pneumonia in Irish Wolfhounds: Clinical findings and etiological studies.

Sanna J Viitanen et al jvim 2019

A

Recurrent BP affects middle-aged IWH (median 5y) w/o immune deficit or primary ciliary defects

focal bronchiectasis is a common finding and likely contributes to development of pneumonia

22
Q

Evaluation of metabolic profile and C-reactive protein concentrations in brachycephalic dogs with upper airway obstructive syndrome.

Paola Gianella, et al jvim 2019

A

BOAS dog have obstructive sleep apnea like syndrome

76% had GI signs
Esophageal deviation, cardia atony, distal esophagitis
87% laryngeal collapse

Incr glucose, fructosamine, triglyceride, CRP, lipoproteins, and chylomicrons

23
Q

Correlations among tracheal dimensions, tracheal stent dimensions, and major complications after endoluminal stenting of tracheal collapse syndrome in dogs.

Nathaniel P Violette, et al jvim 2019

A

Complication (56%): stent fx, obstructive tissue growths, and progressive TC

Stent fx associated w/ nonsurvival

Higher taper in tracheal diameter may lead to increased stent fx in intrathoracic location

Dogs w/ tracheal malformation have higher risk of tracheal inlet fx and development of obstructive tissue growth

24
Q

Eosinophilic bronchitis, eosinophilic granuloma, and eosinophilic bronchopneumopathy in 75 dogs (2006-2016).

Lynelle R Johnson, et al jvim 2019

A

EBP based on TXR, yellow-green mucus in airway, mucosal change + airway collapse

Dogs w/ EB less likely to have bronchiectasis or peripheral eosinophilia, lower TncC in BAL, and lower eosinophil % in BAL

EG= intraluminal mass or bronchoscopically diagnosed, had long survival (>55mo)

25
Q

Clinical features and outcome in 25 dogs with respiratory‐associated pulmonary hypertension treated with sildenafil

Lynelle R. Johnson Joshua A. Stern jvim 2020

A

Syncope, c+, resp distress

PH-induced tracheobronchomalacia, PF, inflammatory airway dz, BOAS

Sildenafil responsiveness was variable but improved QoL in dogs surviving >1 month

26
Q

Bacterial infection before and after stent placement in dogs with tracheal collapse syndrome

Sylvia Lesnikowski et al jvim 2020

A

No diff pre- and post-stent

Decr bacterial infection rate in geriatric dogs and stented dogs w/ traditional collapse

Risk factors for infection: hx of pneumonia and cardiac dz in older dogs; hepatomegaly in young dogs

27
Q

Clinical features and radiographic findings in cats with eosinophilic, neutrophilic, and mixed airway inflammation (2011‐2018)

Elizabeth A. Lee et al jvim 2020

A

BAL samples
C+ is the most common presenting compliant
Eosinophilic inflammation in younger cats than those w/ neutrophilic or mixed inflammation

28
Q

Survival characteristics and prognostic importance of echocardiographic measurements of right heart size and function in dogs with pulmonary hypertension

Lance C. Visser et al jvim 2020

A

RA area, RV function (TAPSE<3.23) and right-sided heart failure were independently associated w/ shorter survival

29
Q

Clinical response to 2 protocols of aerosolized gentamicin in 46 dogs with Bordetella bronchiseptica infection (2012‐2018)

Aude Morgane Canonne et al jvim 2020

A

aerosolized 4mg/kg gentamicin >10 min q12h x 3 weeks

Aerosolized gentamicin works, undiluted 5% solution had better clinical response

30
Q

CCM 2018

Nebulized vs IV amikacin as adjunctive ABX for hospital and VAP postcardiac sx

A

nebulized amikacin had better cure rates, less ICU stay, fewer days to reach complete recovery compared to IV amikacin
less nephrotoxic if nebulized

31
Q

Early Neuromuscular Blockade in the Acute Respiratory Distress Syndrome.

NEJM 2019

A

no significant difference in mortality at 90 days between patients who received an early and continuous cisatracurium infusion

32
Q

CCM2019

Incidence and Outcomes of Acute Laryngeal Injury After Prolonged Mechanical Ventilation.

Justin R Shinn et al

A

acute laryngeal injury occurred in 57% patients

Associated w/ sig. worse breathing and voicing 10w after extubation

33
Q

NEJM 2020

PSP trial: Conservative versus Interventional Treatment for Spontaneous Pneumothorax

A

conservative was non-inferior with lower risk of adverse effects

conservative = no active chest tube

34
Q

NEJM 2020

ICU-ROX: Conservative Oxygen Therapy during Mechanical Ventilation in the ICU

A

use of conservative O2 didn’t change vent-free days

conservative O2 = FiO2 decr to 0.21 and supplemental O2 d/c in patients who had been extubated if SpO2 above acceptable limit (90%)

35
Q

NEJM 2020

Liberal or Conservative Oxygen Therapy for Acute Respiratory Distress Syndrome

A

ARDSnet rec target of PaO2 55-80 mmHg

liberal O2 (PaO2 90-105 mmHg) vs conservative (PaO2 55-70 mmHg) - no diff in survival

36
Q

CCM 2020

Mechanical Ventilation Redistributes Blood to Poorly Ventilated Areas in Experimental Lung Injury

A

In experimental atelectasis with minimal tidal recruitment/derecruitment, mechanical inspiratory breaths redistributed blood volume away from well-ventilated areas, worsening PF ratio

37
Q

CCM 2020

Mean Airway Pressure As a Predictor of 90-Day Mortality in Mechanically Ventilated Patients

A

Mean airway pressure different in survivor vs nonsurvivors (12 vs 13) and was predictive of 90d mortality

38
Q

Assessment of the percutaneous dilatational tracheostomy technique in experimental manikins and canine cadavers.

Mariana A Pardo, et al jvecc 2019

A

Done via seldinger technique

No stat sig diff b/w procedure time and final test trach tube placement in PDT vs ST

39
Q

Characterization of and factors associated with causes of pleural effusion in cats

Marina Domínguez Ruiz, javma 2018

A

23% mortality rate

Cause: CHF, neoplasia&raquo_space; pyothorax, idiopathic chylothorax, trauma, FIP, non-traumatic DH

Cats w/ trauma or FIP were young.
Cats w/ LSA was younger than carcinoma.
Cats w/ CHF had lower rectal temp than all other cats

40
Q

Risk of anesthesia-related complications in brachycephalic dogs

Michaela Gruenheid javma 2018

A

Brachycephalic dogs had higher pre and post-op ax complications

  • Factors associated w/ high peri-ax complication: brachycephalic, longer duration of ax
  • -> risk lowered w/ increasing BW and ortho/radiologic procedure (vs STSx)

-Higher post-ax complication: brachycephalic status, increasing ASA status, use of ketamine + BDZ (vs propofol +/- lidocaine), invasive procedures

41
Q

Retrospective analysis of incidence, clinical features, potential risk factors, and prognostic indicators for aspiration pneumonia in three brachycephalic dog breeds

Hannah P. Darcy, javma 2018

A

Pugs had lower risk compared to bulldogs
Pugs had more neuro signs

Hx of GI signs most common risk factor

Increased age, male sex, obtundation, hypoalbuminemia, azotemia, and ELE were associated with nonsurvival

42
Q

Risk factors for temporary tracheostomy tube placement following surgery to alleviate signs of brachycephalic obstructive airway syndrome in dogs

David B. Worth, javma 2018

A

Every 1 year incr in age incr odds of trach by 30%

Post-op use of steroids + presence of pneumonia associated w/ needing trach

(Resp distress + BCS NOT associated)