Immune-mediated articles Flashcards

1
Q

Pregnancy-associated immune-mediated hemolytic anemia in a dog

Fernandez jvecc 2020

A

42d after matching

Developed IMHA, was on clavamox –> whelped –> PCV started to improve after whelping + clavamox d/c –> clavamox used again later and didn’t cause IMHA

No hyperbilirubinemia + no steroids tx used

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2
Q

Effects of therapeutic plasma exchange on serum immunoglobulin concentrations in a dog with refractory immune-mediated hemolytic anemia

Alyssa M. Scagnelli javma 2018

A

The decrease and rebound in serum IgG and IgM concentrations following TPE provided evidence that TPE may have the same immunomodulatory effects in dogs

TPE may be a useful alternative in dogs with refractory IMHA when traditional treatments fail

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3
Q

Case-control study of plasma mean platelet component concentration and survival analysis for dogs with immune-mediated hemolytic anemia

Andrea Zoia javma 2018

A

IMHA dogs- platelets appeared to have been activated to a greater degree (lower plasma MPC) than healthy dogs or sick dogs w/o IMHA

Estimated risk of death for dogs with IMHA decreased by 16% for every unit increase in plasma MPC concentration

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4
Q

Clinical features of precursor-targeted immune-mediated anemia in dogs: 66 cases (2004–2013)

Tara D. Assenmacher JAVMA 2019

A

Rubriphagocytosis a d collagen myelofibrosis common on BM aspirates

TE events 14% and worsened px (Mst 54d)

73% went into remission, 20% relapsed

MST 913 days

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5
Q

Mortality rate and prognostic factors for dogs with severe anaphylaxis: 67 cases (2016–2018)

M. Ryan Smith JAVMA 2020

A

Mortality rate 15%

Nonsurvivors had high PT, higher phosphorus, lower temp.

Phos >12, hypoglycemia w/in6h, high PT with PTT >50% RI, need for supplemental dextrose associated w/ death.

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6
Q

Neutrophil Extracellular Traps in Plasma from Dogs with Immune-mediated Hemolytic Anemia

Lawson jvim 2018

A

Excessive NETs found in IMHA dogs

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7
Q

Development and implementation of a novel immune thrombocytopenia bleeding score for dogs (DOGiBAT)

Kelly M. Makielski, jvim 2018

A

DOGiBAT: bleeding grades from 0 (none) to 2 (severe) of 9 anatomic sites (cutaneous, catheter or venipuncture bleeding, oral mucosa, intraocular, epistaxis, gastrointestinal, urinary, pulmonary, and intracranial)

  • 1= petechia/ecchymoses, single site
  • 2= petechia/ecchymoses, >2 location

DOGiBAT scores inversely correlated to platelet count and directly correlated to transfusion requirements + LOH

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8
Q

Long‐term outcome of primary immune‐mediated thrombocytopenia in dogs
K. Simpson JSAP 2018

A

90% survived to discharge 31% relapsed (median time 79d)

Long-term use of immunosuppressant doesn’t prevent relapse

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9
Q

Detection and dynamics of anti‐platelet antibodies in thrombocytopenic dogs with and without idiopathic immune thrombocytopenia

Sarah Shropshire jvim 2020

A

20% of 2ry ITP and 100% 1ry ITP tested positive for APA

Presence of APA not associated w/ any outcome measures (response to tx, relapse, prognosis)

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10
Q

Application of therapeutic plasma exchange in dogs with immune‐mediated thrombocytopenia

Lucy Kopecny jvim 2020

A

TPE 4-4.9 total plasma volumes, associated w/ improvement of bleeding + plt count

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11
Q

Effect of dilution of canine blood samples on the specificity of saline agglutination tests for immune‐mediated hemolysis

Sun and Jeffery jvim 2020

A

49:1 saline to blood ratio achieved high Sp for IMHA (97%) = don’t use low saline:blood ratio d/t risk of false +vev

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12
Q

Lyophilized platelets versus cryopreserved platelets for management of bleeding in thrombocytopenic dogs: A multicenter randomized clinical trial

Robert Goggs et al jvim 2020

A

Lyophilized plt was logistically superior (quicker to initiate) and non-inferior to DMSO plts

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