Cardio articles Flashcards
Evaluation of atrial natriuretic peptide and cardiac troponin I concentrations for assessment of disease severity in dogs with naturally occurring mitral valve disease
Yasutomo Hori DVM, et al javma 2020
- Plasma ANP and cTnI increased as dz severity increased
- can detect subclinical stages - Can assess severity and support echo findings
- Can’t use to diagnose
Use of cardiac sphericity index and manubrium heart scores to assess radiographic cardiac silhouettes in large-and small-breed dogs with and without cardiac disease
Ayman A. Mostafa et al, javma 2020
Cardiac sphericity index (CSI) highest w/ R-cardiac dz
High short-, long- and overall MHSs suggestive of L-cardiac dz
High short w/o high long- and overall MHS suggestive of R-side
Prevalence of selected cardiotropic pathogens in the myocardium of adult dogs with unexplained myocardial and rhythm disorders or with congenital heart disease
Roberto A. Santilli et al javma 2019
dogs with unexplained myocardial and rhythm disorders (UMRD)
UMRD dogs more likely to have pathogen than congenital dz dogs – CDV, canine coronavirus, CPV2, Bartonella
Assessment of plasma lactate and core-peripheral temperature gradient in association with stages of naturally occurring myxomatous mitral valve disease in dogs
Felipe B. Soares et al jvecc 2018
Stage C dogs had higher plasma lactate than B2
Core-peripheral temp gradient no diff
Investigation of focused cardiac ultrasound in the emergency room for differentiation of respiratory and cardiac causes of respiratory distress in dogs
Melanie J. Hezzell MA, VetMB, PhD, DACVIM et al jvecc 2020
FOCUS did not significantly improve differentiation of C vs NC causes of respiratory distress compared to medical history and physical examination alone
Resolution of caval syndrome during initial hemodynamic stabilization in dogs with heartworm disease
Romain Pariaut et al jvecc 2020
Caval syndrome - tx with sildenafil, fluids, supplemental O2, 4/5 had pimo –> spontaneous HW migration back to pulmonary arteries 2h-5d after tx
Focused cardiac ultrasound and point-of-care NT-proBNP assay in the emergency room for differentiation of cardiac and noncardiac causes of respiratory distress in cats
Cassandra Ostroski Janson DVM, DACVECC et al jvecc 2020
FOCUS evaluation of basic cardiac structure and LA:Ao by trained emergency clinicians improved accuracy of diagnosis compared to PE in cats with respiratory distress.
Successful management of ventricular fibrillation and ventricular tachycardia using defibrillation and intravenous amiodarone therapy in a cat
Noa Berlin et al jvecc 2020
VF occurs in 20% of CPA cats
No adverse event w/ amiodarone x 6 months
Preliminary evaluation of the efficacy of intravenous magnesium sulfate for the treatment of ventricular arrhythmias in 16 dogs
Amber B. Schoeller et al jvecc 2020
MgSulfate 0.2 mEq/kg IV over 5 minutes
Post-infusion led to increased iMg, decr HR and # of VPC but incr supraventricular ectopic beats at T2
Did not eliminate ventricular tachyarrhythmias @ this dose
Transient Myocardial Thickening in Cats Associated with Heart Failure
J. Novo Matos, et al jvim 2018
Cats were younger than HCM (2 vs 8 yo) with an antecedent event (e.g. Had stressful event, received drugs, or hypersensitivity rx)
-Proposed causes: myocardial edema, transient cellular infiltration, acute myocarditis
LVWT and LA:Ao normalize after 3.3 months
All TMT cats survived and 20/21 d/c cardiac meds
Symmetric Dimethylarginine in Cats with Hypertrophic Cardiomyopathy and Diabetes Mellitus
R. Langhorn, et al jvim 2018
Cats w/ DM had lower SDMA
SDMA no diff b/w control and HCM cats
Retrospective Evaluation of the Effect of Heart Rate on Survival in Dogs with Atrial Fibrillation
B. Pedro et al jvim 2018
- HOLTER HR affected survival
- Dogs with meanHR <125 bpm lived longer than those with meanHR ≥ 125 bpm.
- Every 10 bpm HR incr, risk of mortality incr by 35%
Diagnostic utility of cardiac troponin I in cats with hypertrophic cardiomyopathy
jvim 2018
Increased cTnI concentrations reflect the severity of HCM (aka CHF)
0.234 ng/mL 95% Sn and 78% Sp identifies HCM cats w/ CHF
International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study
jvim 2018
No diff in morbidity, mortality, and cardiovascular survival b/w HCM and HOCM
25% of them experienced cardiovascular death
10% of cats reaching 9-15 years survival
Clinical findings and survival time in dogs with advanced heart failure
Amelie Beaumier et al, jvim 2018
Advanced HF: >4 mg/kg/d lasix, ACEi, pimo
- MST 281 days
- High dose lasix (>6.7 mg/kg/day) and non-hospitalization = better MST.
Acute echocardiographic effects of sotalol on ventricular systolic function in dogs with ventricular arrhythmias
Lance C. Visser et al jvim 2018
Sotalol (2-2.5 mg/kg PO once) mildly decreased LV systolic function indicators except for TAPSE
HR, VPC/5 min and arrhythmia grade decreased after sotalol
Atrioventricular accessory pathways in 89 dogs: Clinical features and outcome after radiofrequency catheter ablation
Kathy N. Wright, et al jvim 2018
Male labs
Non-specific signs- lethargy, GI
Tachycardia-induced cardiomyopathy (TICM) occurred in 46%
Radiofrequency catheter ablation successful in 99%
Evaluation of point-of-care thoracic ultrasound and NT-proBNP for the diagnosis of congestive heart failure in cats with respiratory distress
Jessica L. Ward, et al jvim 2018
POC lung ultrasound, focussed cardiac ultrasound and NT-proBNP useful to dx CHF
FOR CHF:
LAE 97% Sn and 100% Sp
Pericardial eff 100% Sp and 60% Sn
+ NTproBNP 93% Sn 72% Sp
A prospective, randomized, double-blind, placebo-controlled pilot study of sacubitril/valsartan (Entresto) in dogs with cardiomegaly secondary to myxomatous mitral valve disease (Stage B2)
Daniel K. Newhard, et al jvim 2018
Sacubitril/valsartan = combination ARB + NEP inhibitor
-NEP enzyme that cleaves natriuretic peptide; increased NEP associated w/ poor outcome in people
- Effectively inhibit the RAAS in dogs with ACVIM Stage B2 MMVD.
Prognostic factors in dogs with presumed degenerative mitral valve disease attending primary-care veterinary practices in the United Kingdom.
M J Mattin et al jvim 2019
- NT-proBNP strongest predictor of all-cause and cardiac-related mortality
- Increased hazard of death: high NT proBNP, cTnI, female, older, high HR, EI, dyspneic, and co-morbidities
- Increased hazard of cardiac-related death: higher NT-proBNP and cTnI, high HR, heart murmur intensities, EI and receiving potent diuretics
Factors associated with disease progression in dogs with presumed preclinical degenerative mitral valve disease attending primary care veterinary practices in the United Kingdom.
MJ Mattin, et al jvim 2019
NT-proBNP, heart rate, heart murmur intensity, presence of a cough, being a CKCS, and being prescribed pimobendan were associated with clinical progression to initiation of treatment with a potent diuretic or cardiac-related death.