Respiratory

Question 1

Fluticasone

Answer 1

• MOA?
• Bind to intracellular glucocorticoid receptor, resulting in a reduction in inflammatory response
• SE?
• Sore throat
• Dysphone
• Oral candidasis
• Dose?
• Child: 50-100mg twice daily
• Adult:100-200mcg twice daily
• Interactions?
• Itroconazole and ritonavir Cushing’s syndrome

Question 2

Salbutamol

Answer 2

Saba

Question 3

Drugs in tuberculosis

Answer 3

Rifampicin - 6 months (orange body fluid)
Isoniazid - 6 months (periph neuropathy, give with Vit B6)
Ethylbutanol- 2 months (gout)
Pyrozenamide- 2 months

Question 4

What are two brand names for preventors?

Answer 4

Symbicort and seretide

Question 5

Symbicort

Answer 5

Laba + GC

Eformeterol + budesonide

Question 6

Seretide

Answer 6

Salmeterol + fluicasone

Question 7

Eformoterol

Answer 7

• What is eformoterol? laba
• MOA?
• B2 agonist which binds to B2 muscle resceptors, causing smooth muscle relaxation.
• Duration 8-12hrs
• SE?
• Tachycardia, skeletal muscle tremor, arrhythmia, hypokalaemia
• Dose?
• Dry powder inhaler *2 + in conjunction with a glucocorticosteroid.
• Interactions?
• B2 antagonists/