Drug Interactions And Reactions

Question 1

Induction of P-450 enzymes

‘BARBara Steals P(h)ENnYs and Refuses Greasy Carbs’

Answer 1

Barbiturates
St John's wort
Phenytoin 
Rifampicin
Griseofulvin
Carbamazepine

Question 2

Inhibition of P450 enzymes

Answer 2

Quinidine, cimetidine, ketoconazole, INH, grapefruit, erythromycin, sulfonamides

Question 3

Metabolism by P-450 enzymes

Answer 3

Benzodiazepines, amide anaesthetics, metoprolol, propranolol, nifedipine, phenytoin, quinidine, theophylline, warfarin, barbiturates

Question 4

Increase risk of digoxin toxicity

Answer 4

Quinidine, cimetidine, amiodarone, CCB

Question 5

Competition for albumin binding sites

Answer 5

Warfarin
ASA
Phenytoin

Question 6

Blood dyscrasia

Answer 6

Ibuprofen, quinidine, methyldopa, chemotherapeutic agents

Question 7

Haemolysis in G6PD deficient patients

Answer 7

Sulfonamides, INH, ASA< Ibuprofen, nitrofurantoin, primaquine, chloramphenicol

Question 8

Gynecomastia - Some excellent drugs cause awesome knockers

Answer 8

Spironolactone 
Estrogens 
Digitalis 
Cimetidine 
Alcohol use (chronic)
Ketoconazole

Question 9

Stevens Johnsons syndrome

Answer 9

Anticonvulsants
Sulfonamides
Penicillins

Question 10

Photosensitivity

Answer 10

Tetracycline
Amiodarone
Sulfonamide

Question 11

Drug induced SLE

Answer 11

Procainamide hydralazine 
INH 
Penicillamine 
Chlorpromazine
Methyldopa 
Quinidine