Drug Side Effects

Question 1

ACEis

Answer 1

COUGH (dry cough)
Rash 
Proteinuria 
Angioedema 
Taste change
Teratogenic effect

Question 2

Amantadine

Answer 2

Ataxia

LIVEDO RETICULARIS

Question 3

Aminoglycosides

Answer 3

Ototoxicity

Nephrotoxicity (acute tubular necrosis)

Question 4

Amiodarone

Answer 4

Acute: AV block, hypotension, bradycardia.
Chronic: pulmonary FIBROSIS, peripheral deposition–> blue discolouration, arrhythmias, hypo/per THYROIDISM, corneal deposition

Question 5

Amphotericin

Answer 5

Fever rigors, nephrotoxicity, bone marrow suppression, anaemia

Question 6

Antipsychotics

Answer 6

Sedation, acute dystonic reaction, akathisia, parkinsonism, tardive dyskinesia, NMS

Question 7

Azoles

Answer 7

Inhibition of P-450 enzyme

Question 8

Zidovudine

Answer 8

Thrombocytopenia, megaloblastic anaemia

Question 9

Beta blockers

Answer 9

Asthma exacerbation, masking of hypoglycaemia, impotence, bradycardia, AV block, CHF

Question 10

Calcium channel blockers

Answer 10

Peripheral oedema, constipation, cardiac depression

Question 11

Carbamazepine

Answer 11

AGRANULOCYTOSIS, aplastic anaemia, liver toxicity

Question 12

Chloramphenicol

Answer 12

Grey baby syndrome, aplastic anaemia

Question 13

Clonidine

Answer 13

Dry mouth, SEVERE rebound headache and HTN

Question 14

Corticosteroids

Answer 14

Mania, acute hyperglycaemia, immunosuppression, bone mineral loss, thinning of skin, easy bruising, proximal myopathy, cataracts (chronic)

Question 15

Digoxin

Answer 15

GI disturbance, YELLOW VISUAL CHANGE, ARRHYTHMIA (e.g. Junctional tachycardia or SVT)

Question 16

Doxorubicin

Answer 16

CARDIOTOXICITY (cardiomyopathy)

Question 17

Fluoroquinolone

Answer 17

Cartilage damage in children, achilles tendon rupture in adults

Question 18

Frusemide

Answer 18

Ototoxicity, hypokalaemia, nephritis, gout

Question 19

Statins and gemifibrozil

Answer 19

Myositis, reversible increase in LFTs

Question 20

Hydrochlorothiazide

Answer 20

Hypokalaemia, hyponatraemia, hyperuricaemia- gout?, hyperglycemia, hypercalcaemia

Question 21

Isoniazid

Answer 21

Peripheral neuropathy (PREVENT with pyridoxine/Vitamin B6), hepatotoxicity, inhibition of P-450 enzyme, seizure with OD, haemolysis in G6PD deficiency

Question 22

MAOIs

Answer 22

Hypertensive tyramine reaction, serotonin syndrome

Question 23

Methotrexate

Answer 23

Hepatic FIBROSIS, pneumonitis, anaemia

Question 24

Metronidazole

Answer 24

Disulfiram reaction, vestibular dysfunction, metallic taste

Question 25

Niacin

Answer 25

Cutaneous flushing

Question 26

Nitroglycerin - GTN

Answer 26

Hypotension, tachycardia, headache, tolerance

Question 27

Penicillamine

Answer 27

Drug induced SLE, membranous GN

Question 28

Phenytoin

Answer 28

Nystagmus, diplopia, ataxia, arrhythmia (toxic dose), GINGICAL HYPERPLASIA, hirsutism, teratogenic effects

Question 29

Prazosin

Answer 29

First dose hypotension

Question 30

Propylthiouracil

Answer 30

Agranulocytosis, aplastic anaemia

Question 31

Rifampicin

Answer 31

ORANGE-RED secretions. Induction of p-450 enzymes

Question 32

Salicylates

Answer 32

Fever, hyperventilation with respiratory alkalosis and metabolic acidosis, dehydration, diaphoresis, hemorrhagic gastritis

Question 33

TCA

Answer 33

Sedation, coma, anticholinergic effects, seizures, QRS prolongation, arrhythmias

Question 34

Tetracyclines

Answer 34

Tooth discolouration, photosensitivity, Fanconi syndrome (syndrome of inadequate reabsorption at PCT), GI distress

Question 35

Trimethoprim

Answer 35

Megaloblastic anaemia, leukopenia, granulocytopenia

Question 36

Vancomycin

Answer 36

Nephrotoxicity, ototoxicity, red man syndrome (due to histamine release)

Question 37

Drugs that cause malignant hyperthermia

Answer 37

Succinylcholine, halothane